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Abnormal fetal aortic velocity waveform and intellectual function at 7 years of age

Ley, D LU ; Tideman, E LU ; Laurin, J ; Bjerre, I and Marsal, K LU (1996) In Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 8(3). p.5-160
Abstract

Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 148 children (84%) an assessment of overall intellectual ability was performed at 6.5 years of age. Verbal and global IQ was lower in the group with an abnormal fetal aortic blood flow velocity waveform (mean +/- SD 96.0 +/- 17.7 and 95.9 +/- 15.7, respectively; n = 41) compared to the group with a normal waveform (102.1 +/- 12.2 and 102.9 +/- 13.2, respectively; n = 105; p < 0.05). Logistic regression analysis revealed that abnormal fetal aortic velocity waveform, both independently and in... (More)

Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 148 children (84%) an assessment of overall intellectual ability was performed at 6.5 years of age. Verbal and global IQ was lower in the group with an abnormal fetal aortic blood flow velocity waveform (mean +/- SD 96.0 +/- 17.7 and 95.9 +/- 15.7, respectively; n = 41) compared to the group with a normal waveform (102.1 +/- 12.2 and 102.9 +/- 13.2, respectively; n = 105; p < 0.05). Logistic regression analysis revealed that abnormal fetal aortic velocity waveform, both independently and in combination with other factors, was a significant predictor of impaired intellectual outcome. The association found between abnormal fetal aortic velocity waveform and impaired intellectual outcome suggests that hemodynamic evaluation of the fetus has a predictive value regarding postnatal intellectual development.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Analysis of Variance, Aorta, Thoracic/diagnostic imaging, Blood Flow Velocity, Child, Child Development/physiology, Female, Fetal Growth Retardation/complications, Humans, Infant, Newborn, Infant, Small for Gestational Age, Intelligence, Intelligence Tests, Logistic Models, Longitudinal Studies, Male, Predictive Value of Tests, Pregnancy, Prospective Studies, Risk Factors, Ultrasonography, Prenatal
in
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
volume
8
issue
3
pages
5 - 160
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:8915084
  • scopus:0030225637
ISSN
0960-7692
DOI
10.1046/j.1469-0705.1996.08030160.x
language
English
LU publication?
yes
id
e8132059-93a5-403c-9467-b68288dc1900
date added to LUP
2021-02-15 18:54:29
date last changed
2024-03-05 23:56:12
@article{e8132059-93a5-403c-9467-b68288dc1900,
  abstract     = {{<p>Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was &gt; 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 148 children (84%) an assessment of overall intellectual ability was performed at 6.5 years of age. Verbal and global IQ was lower in the group with an abnormal fetal aortic blood flow velocity waveform (mean +/- SD 96.0 +/- 17.7 and 95.9 +/- 15.7, respectively; n = 41) compared to the group with a normal waveform (102.1 +/- 12.2 and 102.9 +/- 13.2, respectively; n = 105; p &lt; 0.05). Logistic regression analysis revealed that abnormal fetal aortic velocity waveform, both independently and in combination with other factors, was a significant predictor of impaired intellectual outcome. The association found between abnormal fetal aortic velocity waveform and impaired intellectual outcome suggests that hemodynamic evaluation of the fetus has a predictive value regarding postnatal intellectual development.</p>}},
  author       = {{Ley, D and Tideman, E and Laurin, J and Bjerre, I and Marsal, K}},
  issn         = {{0960-7692}},
  keywords     = {{Analysis of Variance; Aorta, Thoracic/diagnostic imaging; Blood Flow Velocity; Child; Child Development/physiology; Female; Fetal Growth Retardation/complications; Humans; Infant, Newborn; Infant, Small for Gestational Age; Intelligence; Intelligence Tests; Logistic Models; Longitudinal Studies; Male; Predictive Value of Tests; Pregnancy; Prospective Studies; Risk Factors; Ultrasonography, Prenatal}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{5--160}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology}},
  title        = {{Abnormal fetal aortic velocity waveform and intellectual function at 7 years of age}},
  url          = {{http://dx.doi.org/10.1046/j.1469-0705.1996.08030160.x}},
  doi          = {{10.1046/j.1469-0705.1996.08030160.x}},
  volume       = {{8}},
  year         = {{1996}},
}