Abnormal fetal aortic velocity waveform and intellectual function at 7 years of age
(1996) In Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 8(3). p.5-160- Abstract
Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 148 children (84%) an assessment of overall intellectual ability was performed at 6.5 years of age. Verbal and global IQ was lower in the group with an abnormal fetal aortic blood flow velocity waveform (mean +/- SD 96.0 +/- 17.7 and 95.9 +/- 15.7, respectively; n = 41) compared to the group with a normal waveform (102.1 +/- 12.2 and 102.9 +/- 13.2, respectively; n = 105; p < 0.05). Logistic regression analysis revealed that abnormal fetal aortic velocity waveform, both independently and in... (More)
Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 148 children (84%) an assessment of overall intellectual ability was performed at 6.5 years of age. Verbal and global IQ was lower in the group with an abnormal fetal aortic blood flow velocity waveform (mean +/- SD 96.0 +/- 17.7 and 95.9 +/- 15.7, respectively; n = 41) compared to the group with a normal waveform (102.1 +/- 12.2 and 102.9 +/- 13.2, respectively; n = 105; p < 0.05). Logistic regression analysis revealed that abnormal fetal aortic velocity waveform, both independently and in combination with other factors, was a significant predictor of impaired intellectual outcome. The association found between abnormal fetal aortic velocity waveform and impaired intellectual outcome suggests that hemodynamic evaluation of the fetus has a predictive value regarding postnatal intellectual development.
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- author
- Ley, D LU ; Tideman, E LU ; Laurin, J ; Bjerre, I and Marsal, K LU
- organization
- publishing date
- 1996-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Analysis of Variance, Aorta, Thoracic/diagnostic imaging, Blood Flow Velocity, Child, Child Development/physiology, Female, Fetal Growth Retardation/complications, Humans, Infant, Newborn, Infant, Small for Gestational Age, Intelligence, Intelligence Tests, Logistic Models, Longitudinal Studies, Male, Predictive Value of Tests, Pregnancy, Prospective Studies, Risk Factors, Ultrasonography, Prenatal
- in
- Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
- volume
- 8
- issue
- 3
- pages
- 5 - 160
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:8915084
- scopus:0030225637
- ISSN
- 0960-7692
- DOI
- 10.1046/j.1469-0705.1996.08030160.x
- language
- English
- LU publication?
- yes
- id
- e8132059-93a5-403c-9467-b68288dc1900
- date added to LUP
- 2021-02-15 18:54:29
- date last changed
- 2024-03-05 23:56:12
@article{e8132059-93a5-403c-9467-b68288dc1900, abstract = {{<p>Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 148 children (84%) an assessment of overall intellectual ability was performed at 6.5 years of age. Verbal and global IQ was lower in the group with an abnormal fetal aortic blood flow velocity waveform (mean +/- SD 96.0 +/- 17.7 and 95.9 +/- 15.7, respectively; n = 41) compared to the group with a normal waveform (102.1 +/- 12.2 and 102.9 +/- 13.2, respectively; n = 105; p < 0.05). Logistic regression analysis revealed that abnormal fetal aortic velocity waveform, both independently and in combination with other factors, was a significant predictor of impaired intellectual outcome. The association found between abnormal fetal aortic velocity waveform and impaired intellectual outcome suggests that hemodynamic evaluation of the fetus has a predictive value regarding postnatal intellectual development.</p>}}, author = {{Ley, D and Tideman, E and Laurin, J and Bjerre, I and Marsal, K}}, issn = {{0960-7692}}, keywords = {{Analysis of Variance; Aorta, Thoracic/diagnostic imaging; Blood Flow Velocity; Child; Child Development/physiology; Female; Fetal Growth Retardation/complications; Humans; Infant, Newborn; Infant, Small for Gestational Age; Intelligence; Intelligence Tests; Logistic Models; Longitudinal Studies; Male; Predictive Value of Tests; Pregnancy; Prospective Studies; Risk Factors; Ultrasonography, Prenatal}}, language = {{eng}}, number = {{3}}, pages = {{5--160}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology}}, title = {{Abnormal fetal aortic velocity waveform and intellectual function at 7 years of age}}, url = {{http://dx.doi.org/10.1046/j.1469-0705.1996.08030160.x}}, doi = {{10.1046/j.1469-0705.1996.08030160.x}}, volume = {{8}}, year = {{1996}}, }