No association between troponin and COPD without cardiovascular influence : findings from a population-based cohort (SCAPIS)
Eriksson Ström, Jonas ; Pesonen, Ida ; Liv, Per ; Andersson, Anders ; Bossios, Apostolos ; Egesten, Arne LU ; Ekström, Magnus LU
; Engvall, Jan
; Good, Elin
and Hammarsten, Ola
, et al.
(2026)
In Thorax
- Abstract
Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26; highest category vs below limit of detection) or with forced expiratory volume in 1 s/forced vital capacity (adjusted difference 0.002, 95% CI −0.001 to 0.004). Median TnI was 2.2 ng/L in both obstructive and non-obstructive groups. These findings do not support a pulmonary source of TnI elevation in mild to moderate, stable COPD and suggest... (More)
Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26; highest category vs below limit of detection) or with forced expiratory volume in 1 s/forced vital capacity (adjusted difference 0.002, 95% CI −0.001 to 0.004). Median TnI was 2.2 ng/L in both obstructive and non-obstructive groups. These findings do not support a pulmonary source of TnI elevation in mild to moderate, stable COPD and suggest that TnI elevations should prompt cardiovascular evaluation rather than being attributed to pulmonary disease alone.
(Less)
- author
- Eriksson Ström, Jonas
; Pesonen, Ida
; Liv, Per
; Andersson, Anders
; Bossios, Apostolos
; Egesten, Arne
LU
; Ekström, Magnus
LU
; Engvall, Jan
; Good, Elin
and Hammarsten, Ola
, et al. (More)
- Eriksson Ström, Jonas
; Pesonen, Ida
; Liv, Per
; Andersson, Anders
; Bossios, Apostolos
; Egesten, Arne
LU
; Ekström, Magnus
LU
; Engvall, Jan
; Good, Elin
; Hammarsten, Ola
; Holm, Jonas
; Janson, Christer
; Johnsson, Åse
; Lind, Lars
; Lindberg, Eva
; Lindén, Anders
; Malinovschi, Andrei
LU
; Moberg, Anna
; Nilsson, Ulf
; Palmqvist, Emma
; Skold, Magnus
; Sundh, Josefin
; Tanash, Hanan A.
LU
; Zaigham, Suneela
LU
and Blomberg, Anders
(Less)
- organization
-
- Respiratory Medicine, Allergology, and Palliative Medicine
- Novel strategies targeting detrimental airway inflammation (research group)
- Hereditary angioedema (HAE) – epidemiology, genetics and pathophysiology (research group)
- Infect@LU
- EpiHealth: Epidemiology for Health
- Breathlessness and chronic respiratory failure (research group)
- The Institute for Palliative Care (research group)
- Cardiovascular Research - Epidemiology (research group)
- publishing date
- 2026
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- COPD epidemiology, COPD Pathology
- in
- Thorax
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:105039469002
- pmid:41895854
- ISSN
- 0040-6376
- DOI
- 10.1136/thorax-2025-224120
- language
- English
- LU publication?
- yes
- id
- e9a33cba-58e7-417a-b6ab-52183e8afa45
- date added to LUP
- 2026-08-25 14:00:44
- date last changed
- 2026-08-25 14:01:26
@article{e9a33cba-58e7-417a-b6ab-52183e8afa45,
abstract = {{<p>Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26; highest category vs below limit of detection) or with forced expiratory volume in 1 s/forced vital capacity (adjusted difference 0.002, 95% CI −0.001 to 0.004). Median TnI was 2.2 ng/L in both obstructive and non-obstructive groups. These findings do not support a pulmonary source of TnI elevation in mild to moderate, stable COPD and suggest that TnI elevations should prompt cardiovascular evaluation rather than being attributed to pulmonary disease alone.</p>}},
author = {{Eriksson Ström, Jonas and Pesonen, Ida and Liv, Per and Andersson, Anders and Bossios, Apostolos and Egesten, Arne and Ekström, Magnus and Engvall, Jan and Good, Elin and Hammarsten, Ola and Holm, Jonas and Janson, Christer and Johnsson, Åse and Lind, Lars and Lindberg, Eva and Lindén, Anders and Malinovschi, Andrei and Moberg, Anna and Nilsson, Ulf and Palmqvist, Emma and Skold, Magnus and Sundh, Josefin and Tanash, Hanan A. and Zaigham, Suneela and Blomberg, Anders}},
issn = {{0040-6376}},
keywords = {{COPD epidemiology; COPD Pathology}},
language = {{eng}},
publisher = {{BMJ Publishing Group}},
series = {{Thorax}},
title = {{No association between troponin and COPD without cardiovascular influence : findings from a population-based cohort (SCAPIS)}},
url = {{http://dx.doi.org/10.1136/thorax-2025-224120}},
doi = {{10.1136/thorax-2025-224120}},
year = {{2026}},
}