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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Speliotes, Elizabeth K.; Willer, Cristen J.; Berndt, Sonja I.; Monda, Keri L.; Thorleifsson, Gudmar; Jackson, Anne U.; Allen, Hana Lango; Lindgren, Cecilia M.; Luan, Jian'an and Maegi, Reedik, et al. (2010) In Nature Genetics 42(11). p.53-937
Abstract
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may... (More)
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation. (Less)
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Nature Genetics
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42
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11
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53 - 937
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Nature Publishing Group
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  • scopus:78049337953
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1546-1718
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10.1038/ng.686
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English
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@article{e9b5a2fa-c736-40eb-a097-82d3accf364d,
  abstract     = {Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P &lt; 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.},
  author       = {Speliotes, Elizabeth K. and Willer, Cristen J. and Berndt, Sonja I. and Monda, Keri L. and Thorleifsson, Gudmar and Jackson, Anne U. and Allen, Hana Lango and Lindgren, Cecilia M. and Luan, Jian'an and Maegi, Reedik and Randall, Joshua C. and Vedantam, Sailaja and Winkler, Thomas W. and Qi, Lu and Workalemahu, Tsegaselassie and Heid, Iris M. and Steinthorsdottir, Valgerdur and Stringham, Heather M. and Weedon, Michael N. and Wheeler, Eleanor and Wood, Andrew R. and Ferreira, Teresa and Weyant, Robert J. and Segre, Ayellet V. and Estrada, Karol and Liang, Liming and Nemesh, James and Park, Ju-Hyun and Gustafsson, Stefan and Kilpelaenen, Tuomas O. and Yang, Jian and Bouatia-Naji, Nabila and Esko, Tonu and Feitosa, Mary F. and Kutalik, Zoltan and Mangino, Massimo and Raychaudhuri, Soumya and Scherag, Andre and Smith, Albert Vernon and Welch, Ryan and Zhao, Jing Hua and Aben, Katja K. and Absher, Devin M. and Amin, Najaf and Dixon, Anna L. and Fisher, Eva and Glazer, Nicole L. and Goddard, Michael E. and Heard-Costa, Nancy L. and Hoesel, Volker and Hottenga, Jouke-Jan and Johansson, Asa and Johnson, Toby and Ketkar, Shamika and Lamina, Claudia and Li, Shengxu and Moffatt, Miriam F. and Myers, Richard H. and Narisu, Narisu and Perry, John R. 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  issn         = {1546-1718},
  language     = {eng},
  number       = {11},
  pages        = {53--937},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index},
  url          = {http://dx.doi.org/10.1038/ng.686},
  volume       = {42},
  year         = {2010},
}