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Glucose effectiveness : Lessons from studies on insulin-independent glucose clearance in mice

Ahrén, Bo LU and Pacini, Giovanni (2020) In Journal of Diabetes Investigation
Abstract

Besides insulin-mediated transport of glucose into the cells, an important role is also played by the non-insulin-mediated transport. This latter process is called glucose effectiveness (acronym SG), which is estimated by modeling of glucose and insulin data after an intravenous glucose administration, and accounts for ≈70% of glucose disposal. This review summarizes studies on SG, mainly in humans and rodents with focus on results achieved in model experiments in mice. In humans, SG is reduced in type 2 diabetes, in obesity, in liver cirrhosis and in some elderly populations. In model experiments in mice, SG is independent from glucose levels, but increases when insulin secretion is... (More)

Besides insulin-mediated transport of glucose into the cells, an important role is also played by the non-insulin-mediated transport. This latter process is called glucose effectiveness (acronym SG), which is estimated by modeling of glucose and insulin data after an intravenous glucose administration, and accounts for ≈70% of glucose disposal. This review summarizes studies on SG, mainly in humans and rodents with focus on results achieved in model experiments in mice. In humans, SG is reduced in type 2 diabetes, in obesity, in liver cirrhosis and in some elderly populations. In model experiments in mice, SG is independent from glucose levels, but increases when insulin secretion is stimulated, such as after administration of the incretin hormones, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. SG is reduced in insulin resistance induced by high-fat feeding and by exogenous administration of glucagon. Glucose-dependent (insulin-independent) glucose disposal is therefore important for glucose elimination, and it is also well regulated. It might be of pathophysiological relevance for the development of type 2 diabetes, in particular during insulin resistance, and might also be a target for glucose-reducing therapy. Measuring SG is essentially important when carrying out metabolic studies to understand glucose homeostasis.

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publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Glucose disposal, Glucose effectiveness, Mathematical modeling
in
Journal of Diabetes Investigation
publisher
Wiley-Blackwell
external identifiers
  • pmid:33098240
  • scopus:85096949858
ISSN
2040-1116
DOI
10.1111/jdi.13446
language
English
LU publication?
yes
id
eaa493f3-1987-4284-b174-351810bc80bc
date added to LUP
2020-12-14 09:22:17
date last changed
2021-06-02 01:16:49
@article{eaa493f3-1987-4284-b174-351810bc80bc,
  abstract     = {<p>Besides insulin-mediated transport of glucose into the cells, an important role is also played by the non-insulin-mediated transport. This latter process is called glucose effectiveness (acronym S<sub>G</sub>), which is estimated by modeling of glucose and insulin data after an intravenous glucose administration, and accounts for ≈70% of glucose disposal. This review summarizes studies on S<sub>G</sub>, mainly in humans and rodents with focus on results achieved in model experiments in mice. In humans, S<sub>G</sub> is reduced in type 2 diabetes, in obesity, in liver cirrhosis and in some elderly populations. In model experiments in mice, S<sub>G</sub> is independent from glucose levels, but increases when insulin secretion is stimulated, such as after administration of the incretin hormones, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. S<sub>G</sub> is reduced in insulin resistance induced by high-fat feeding and by exogenous administration of glucagon. Glucose-dependent (insulin-independent) glucose disposal is therefore important for glucose elimination, and it is also well regulated. It might be of pathophysiological relevance for the development of type 2 diabetes, in particular during insulin resistance, and might also be a target for glucose-reducing therapy. Measuring S<sub>G</sub> is essentially important when carrying out metabolic studies to understand glucose homeostasis.</p>},
  author       = {Ahrén, Bo and Pacini, Giovanni},
  issn         = {2040-1116},
  language     = {eng},
  month        = {10},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Diabetes Investigation},
  title        = {Glucose effectiveness : Lessons from studies on insulin-independent glucose clearance in mice},
  url          = {http://dx.doi.org/10.1111/jdi.13446},
  doi          = {10.1111/jdi.13446},
  year         = {2020},
}