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Effects of delayed cord clamping on neurodevelopment and infection at four months of age : A randomised trial

Andersson, Ola LU orcid ; Domellöf, Magnus ; Andersson, Dan and Hellström-Westas, Lena LU (2013) In Acta Paediatrica, International Journal of Paediatrics 102(5). p.525-531
Abstract

Aim To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G (IgG) and symptoms of infection during the first 4 months of life. Methods Full-term infants (n = 382) were randomised to delayed (≥180 sec) or early cord clamping (≤10 sec). The Ages and Stages Questionnaire (ASQ) was used to assess neurodevelopment at 4 months. Immunoglobulin G was measured at birth, 2-3 days and 4 months. Parents recorded any symptoms indicating infection during the first 4 months of life. Results The total scores from the ASQ did not differ between groups. However, the delayed cord clamping (DCC) group had a higher mean (SD) score in the problem-solving domain [55.3 (7.2) vs. 53.5 (8.2), p = 0.03]... (More)

Aim To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G (IgG) and symptoms of infection during the first 4 months of life. Methods Full-term infants (n = 382) were randomised to delayed (≥180 sec) or early cord clamping (≤10 sec). The Ages and Stages Questionnaire (ASQ) was used to assess neurodevelopment at 4 months. Immunoglobulin G was measured at birth, 2-3 days and 4 months. Parents recorded any symptoms indicating infection during the first 4 months of life. Results The total scores from the ASQ did not differ between groups. However, the delayed cord clamping (DCC) group had a higher mean (SD) score in the problem-solving domain [55.3 (7.2) vs. 53.5 (8.2), p = 0.03] at 4 months and a lower mean (SD) score in the personal-social domain [49.5 (9.3) vs. 51.8 (8.1), p = 0.01]. The IgG level was higher in the DCC group at 2-3 days (11.7 vs. 11.0 g/L, p = 0.004), but did not differ between the groups at 4 months. Symptoms of infection were comparable between the groups. Conclusion Delayed cord clamping did not affect overall neurodevelopment or symptoms of infection up to 4 months of age, but may have an impact on specific neurodevelopmental domains.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Infant, Infection, Neurodevelopment, Umbilical cord clamping
in
Acta Paediatrica, International Journal of Paediatrics
volume
102
issue
5
pages
7 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:84876108728
  • pmid:23336628
ISSN
0803-5253
DOI
10.1111/apa.12168
language
English
LU publication?
no
id
eb879c35-d9eb-4915-9a4f-b333274b677d
date added to LUP
2019-06-19 06:43:25
date last changed
2024-07-24 22:05:20
@article{eb879c35-d9eb-4915-9a4f-b333274b677d,
  abstract     = {{<p>Aim To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G (IgG) and symptoms of infection during the first 4 months of life. Methods Full-term infants (n = 382) were randomised to delayed (≥180 sec) or early cord clamping (≤10 sec). The Ages and Stages Questionnaire (ASQ) was used to assess neurodevelopment at 4 months. Immunoglobulin G was measured at birth, 2-3 days and 4 months. Parents recorded any symptoms indicating infection during the first 4 months of life. Results The total scores from the ASQ did not differ between groups. However, the delayed cord clamping (DCC) group had a higher mean (SD) score in the problem-solving domain [55.3 (7.2) vs. 53.5 (8.2), p = 0.03] at 4 months and a lower mean (SD) score in the personal-social domain [49.5 (9.3) vs. 51.8 (8.1), p = 0.01]. The IgG level was higher in the DCC group at 2-3 days (11.7 vs. 11.0 g/L, p = 0.004), but did not differ between the groups at 4 months. Symptoms of infection were comparable between the groups. Conclusion Delayed cord clamping did not affect overall neurodevelopment or symptoms of infection up to 4 months of age, but may have an impact on specific neurodevelopmental domains.</p>}},
  author       = {{Andersson, Ola and Domellöf, Magnus and Andersson, Dan and Hellström-Westas, Lena}},
  issn         = {{0803-5253}},
  keywords     = {{Infant; Infection; Neurodevelopment; Umbilical cord clamping}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{5}},
  pages        = {{525--531}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics}},
  title        = {{Effects of delayed cord clamping on neurodevelopment and infection at four months of age : A randomised trial}},
  url          = {{http://dx.doi.org/10.1111/apa.12168}},
  doi          = {{10.1111/apa.12168}},
  volume       = {{102}},
  year         = {{2013}},
}