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Lp-PLA 2 activity and mass and CRP are associated with incident symptomatic peripheral arterial disease

Fatemi, Shahab LU ; Gottsäter, Anders LU ; Zarrouk, Moncef LU ; Engström, Gunnar LU ; Melander, Olle LU ; Persson, Margaretha LU and Acosta, Stefan LU (2019) In Scientific Reports 9(1).
Abstract


Long follow up is needed in prospective cohort study evaluation of plasma biomarkers for incident peripheral arterial disease (PAD) Middle-aged PAD-free individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5550; 1991–94) were followed prospectively for a median time of 23.4 years. The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA
2
) activity and mass, proneurotensin, and CRP, were studied in relation to incidence of PAD until December 31
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Long follow up is needed in prospective cohort study evaluation of plasma biomarkers for incident peripheral arterial disease (PAD) Middle-aged PAD-free individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5550; 1991–94) were followed prospectively for a median time of 23.4 years. The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA
2
) activity and mass, proneurotensin, and CRP, were studied in relation to incidence of PAD until December 31
st
, 2016. The diagnosis of PAD could be validated and confirmed in 98%. Cox regression was used to calculate hazard ratios (HR) per 1 standard deviation increment of each respective log transformed plasma biomarker. Cumulative incidence of PAD was 4.4% (men 5.9%, women 3.3%). Adjusting for age, gender, smoking, body mass index, hypertension, diabetes mellitus, Lp-PLA
2
activity (HR 1.33; 95% CI 1.17–1.52), Lp-PLA
2
mass (HR 1.20; 95% CI 1.05–1.37) and CRP (HR 1.55; 95% CI 1.36–1.76) remained independently associated with incident PAD. The plasma biomarkers Lp-PLA
2
activity and mass, and CRP were markers of PAD risk, implying that they might be useful biomarkers for subclinical atherosclerosis and atherosclerotic disease.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
9
issue
1
publisher
Nature Publishing Group
external identifiers
  • scopus:85063989570
ISSN
2045-2322
DOI
10.1038/s41598-019-42154-5
language
English
LU publication?
yes
id
ebc89987-226d-4fcc-a2ad-26c57ee32d34
date added to LUP
2019-04-24 08:35:40
date last changed
2019-08-23 02:16:48
@article{ebc89987-226d-4fcc-a2ad-26c57ee32d34,
  abstract     = {<p><br>
                                                         Long follow up is needed in prospective cohort study evaluation of plasma biomarkers for incident peripheral arterial disease (PAD) Middle-aged PAD-free individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5550; 1991–94) were followed prospectively for a median time of 23.4 years. The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA                             <br>
                            <sub>2</sub><br>
                                                         ) activity and mass, proneurotensin, and CRP, were studied in relation to incidence of PAD until December 31                             <br>
                            <sup>st</sup><br>
                                                         , 2016. The diagnosis of PAD could be validated and confirmed in 98%. Cox regression was used to calculate hazard ratios (HR) per 1 standard deviation increment of each respective log transformed plasma biomarker. Cumulative incidence of PAD was 4.4% (men 5.9%, women 3.3%). Adjusting for age, gender, smoking, body mass index, hypertension, diabetes mellitus, Lp-PLA                             <br>
                            <sub>2</sub><br>
                                                          activity (HR 1.33; 95% CI 1.17–1.52), Lp-PLA                             <br>
                            <sub>2</sub><br>
                                                          mass (HR 1.20; 95% CI 1.05–1.37) and CRP (HR 1.55; 95% CI 1.36–1.76) remained independently associated with incident PAD. The plasma biomarkers Lp-PLA                             <br>
                            <sub>2</sub><br>
                                                          activity and mass, and CRP were markers of PAD risk, implying that they might be useful biomarkers for subclinical atherosclerosis and atherosclerotic disease.                         <br>
                        </p>},
  articleno    = {5609},
  author       = {Fatemi, Shahab and Gottsäter, Anders and Zarrouk, Moncef and Engström, Gunnar and Melander, Olle and Persson, Margaretha and Acosta, Stefan},
  issn         = {2045-2322},
  language     = {eng},
  month        = {04},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Lp-PLA                         
                        <sub>2</sub>
                                                  activity and mass and CRP are associated with incident symptomatic peripheral arterial disease},
  url          = {http://dx.doi.org/10.1038/s41598-019-42154-5},
  volume       = {9},
  year         = {2019},
}