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Second primary cancers in non-Hodgkin lymphoma : Family history and survival

Chattopadhyay, Subhayan LU ; Zheng, Guoqiao LU ; Sud, Amit LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU ; Houlston, Richard; Hemminki, Akseli and Hemminki, Kari LU (2019) In International Journal of Cancer
Abstract

Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses and family history of cancer may be a risk factor for SPCs. Using the Swedish Family-Cancer Database on non-Hodgkin lymphoma (NHL), we assessed the influence of family history on risk of SPCs and of SPCs on survival. NHL patients were identified from the years 1958 to 2015 and generalized Poisson models were used to calculate relative risks (RRs) for SPCs and familial SPCs. Among 14,393 NHL patients, a total of 1,866 (13.0%) were diagnosed with SPC. Familial risk of nine particular cancers was associated with risks of these cancers as SPCs, with twofold to fivefold increase in RRs. At the end of a 25-year follow-up... (More)

Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses and family history of cancer may be a risk factor for SPCs. Using the Swedish Family-Cancer Database on non-Hodgkin lymphoma (NHL), we assessed the influence of family history on risk of SPCs and of SPCs on survival. NHL patients were identified from the years 1958 to 2015 and generalized Poisson models were used to calculate relative risks (RRs) for SPCs and familial SPCs. Among 14,393 NHL patients, a total of 1,866 (13.0%) were diagnosed with SPC. Familial risk of nine particular cancers was associated with risks of these cancers as SPCs, with twofold to fivefold increase in RRs. At the end of a 25-year follow-up period, the survival probability for persons with SPC was only 20% of that for patients without SPC; the hazard ratio for SPC was 1.59 (95% CI: 1.46–1.72). Survival could be predicted by the prognostic groups based on first cancers and HRs increase systematically with worse prognosis yielding a trend of p = 4.6 × 10 −5 . SPCs had deleterious consequences for survival in NHL patients. Family history was associated with increasing numbers of SPCs. Prevention of SPCs and their early detection is an important target in the overall strategy to improve survival in NHL patients. Counseling for avoidance of risk factors and targeted screening based on family history are feasible steps in risk reduction.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
familial risk, prevention, prognostic grouping, second cancers, survival
in
International Journal of Cancer
publisher
John Wiley & Sons
external identifiers
  • scopus:85065987515
ISSN
0020-7136
DOI
10.1002/ijc.32391
language
English
LU publication?
yes
id
ebcc8f3f-ff0e-4b2a-b6ba-ff45bad4827f
date added to LUP
2019-06-17 15:58:33
date last changed
2019-07-16 10:45:17
@article{ebcc8f3f-ff0e-4b2a-b6ba-ff45bad4827f,
  abstract     = {<p>                             Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses and family history of cancer may be a risk factor for SPCs. Using the Swedish Family-Cancer Database on non-Hodgkin lymphoma (NHL), we assessed the influence of family history on risk of SPCs and of SPCs on survival. NHL patients were identified from the years 1958 to 2015 and generalized Poisson models were used to calculate relative risks (RRs) for SPCs and familial SPCs. Among 14,393 NHL patients, a total of 1,866 (13.0%) were diagnosed with SPC. Familial risk of nine particular cancers was associated with risks of these cancers as SPCs, with twofold to fivefold increase in RRs. At the end of a 25-year follow-up period, the survival probability for persons with SPC was only 20% of that for patients without SPC; the hazard ratio for SPC was 1.59 (95% CI: 1.46–1.72). Survival could be predicted by the prognostic groups based on first cancers and HRs increase systematically with worse prognosis yielding a trend of p = 4.6 × 10                             <sup>−5</sup>                             . SPCs had deleterious consequences for survival in NHL patients. Family history was associated with increasing numbers of SPCs. Prevention of SPCs and their early detection is an important target in the overall strategy to improve survival in NHL patients. Counseling for avoidance of risk factors and targeted screening based on family history are feasible steps in risk reduction.                         </p>},
  author       = {Chattopadhyay, Subhayan and Zheng, Guoqiao and Sud, Amit and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Houlston, Richard and Hemminki, Akseli and Hemminki, Kari},
  issn         = {0020-7136},
  keyword      = {familial risk,prevention,prognostic grouping,second cancers,survival},
  language     = {eng},
  month        = {05},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Second primary cancers in non-Hodgkin lymphoma : Family history and survival},
  url          = {http://dx.doi.org/10.1002/ijc.32391},
  year         = {2019},
}