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Preconception health as a target for improved pregnancy outcomes : Where do we go from here?

Jancsura, M. K. ; Bernstein, Ira ; Hansson, Stefan R. LU orcid ; Cantonwine, David E. ; Godfrey, Keith M. ; Stephenson, Judith ; Steegers-Theunissen, Régine ; Norris, Shane ; Heider, Dominik and Roberts, James M. (2026) In Pregnancy Hypertension 43.
Abstract

Preconception health status, especially of women, but also of men, is known to influence pregnancy outcomes. Despite knowledge of the growing importance of preconception health, numerous challenges remain for conducting research in this population and delivering appropriate clinical care. The 2023 Global Pregnancy Collaboration annual workshop focused on exploring preconception health as it relates to adverse pregnancy outcomes. Here we summarize the proceedings and the current state of the science. We particularly focus on quantifying the exposome as a rich target for investigation of factors that increase the risk for and/ or contribute to preeclampsia and other adverse pregnancy outcomes. We conclude with recommendations for the... (More)

Preconception health status, especially of women, but also of men, is known to influence pregnancy outcomes. Despite knowledge of the growing importance of preconception health, numerous challenges remain for conducting research in this population and delivering appropriate clinical care. The 2023 Global Pregnancy Collaboration annual workshop focused on exploring preconception health as it relates to adverse pregnancy outcomes. Here we summarize the proceedings and the current state of the science. We particularly focus on quantifying the exposome as a rich target for investigation of factors that increase the risk for and/ or contribute to preeclampsia and other adverse pregnancy outcomes. We conclude with recommendations for the scientific and clinical community to address knowledge gaps regarding the links between preconception health and adverse pregnancy outcomes.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diet, Environment, Exposome, Preconception, Preeclampsia
in
Pregnancy Hypertension
volume
43
article number
101395
publisher
Elsevier
external identifiers
  • pmid:41344000
  • scopus:105029714221
ISSN
2210-7789
DOI
10.1016/j.preghy.2025.101395
language
English
LU publication?
yes
id
ebe583fb-48e2-4a22-aa7e-4fda970f26eb
date added to LUP
2026-02-27 14:53:14
date last changed
2026-06-20 06:14:27
@article{ebe583fb-48e2-4a22-aa7e-4fda970f26eb,
  abstract     = {{<p>Preconception health status, especially of women, but also of men, is known to influence pregnancy outcomes. Despite knowledge of the growing importance of preconception health, numerous challenges remain for conducting research in this population and delivering appropriate clinical care. The 2023 Global Pregnancy Collaboration annual workshop focused on exploring preconception health as it relates to adverse pregnancy outcomes. Here we summarize the proceedings and the current state of the science. We particularly focus on quantifying the exposome as a rich target for investigation of factors that increase the risk for and/ or contribute to preeclampsia and other adverse pregnancy outcomes. We conclude with recommendations for the scientific and clinical community to address knowledge gaps regarding the links between preconception health and adverse pregnancy outcomes.</p>}},
  author       = {{Jancsura, M. K. and Bernstein, Ira and Hansson, Stefan R. and Cantonwine, David E. and Godfrey, Keith M. and Stephenson, Judith and Steegers-Theunissen, Régine and Norris, Shane and Heider, Dominik and Roberts, James M.}},
  issn         = {{2210-7789}},
  keywords     = {{Diet; Environment; Exposome; Preconception; Preeclampsia}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Pregnancy Hypertension}},
  title        = {{Preconception health as a target for improved pregnancy outcomes : Where do we go from here?}},
  url          = {{http://dx.doi.org/10.1016/j.preghy.2025.101395}},
  doi          = {{10.1016/j.preghy.2025.101395}},
  volume       = {{43}},
  year         = {{2026}},
}