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An fMRI-study on single-sided deafness : Spectral-temporal properties and side of stimulation modulates hemispheric dominance

Heggdal, Peder O.Laugen; Aarstad, Hans Jørgen; Brännström, J. LU ; Vassbotn, Flemming S. and Specht, Karsten (2019) In NeuroImage: Clinical 24.
Abstract

Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in normal hearing controls. We hypothesised that the response to monaural stimulation in both normal hearing subjects and persons with single-sided deafness would vary with the complexity and nature of the stimuli and the side of stimulation. Design: Patients with left- and right single-sided deafness and controls with normal hearing receiving either binaural or monaural stimuli were tested using speech and non-speech auditory stimuli in an event-related fMRI experiment. Study sample: Twenty-two patients with single-sided... (More)

Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in normal hearing controls. We hypothesised that the response to monaural stimulation in both normal hearing subjects and persons with single-sided deafness would vary with the complexity and nature of the stimuli and the side of stimulation. Design: Patients with left- and right single-sided deafness and controls with normal hearing receiving either binaural or monaural stimuli were tested using speech and non-speech auditory stimuli in an event-related fMRI experiment. Study sample: Twenty-two patients with single-sided deafness after treatment for vestibular schwannoma and 50 normal hearing controls. Results: Normal hearing persons receiving right side monaural stimuli activate bilateral temporal regions. Activation following left side monaural stimulation is more right lateralized. Persons with single-sided deafness respond similarly to controls to monaural stimulation. Persons with right side single-sided deafness show activation of frontal cortical regions not seen in persons with left side single-sided deafness following speech stimuli. This is possibly related to increased effort and more frequently reported problems with communication. Right side single-sided deafness is related to increased activation of areas usually related to processing of degraded input, including the thalamus. Conclusion: Hemispheric dominance following monaural auditory stimulation is modulated by the spectral-temporal properties of the stimuli and by which ear is stimulated. Differences between patients with right- and left side deafness suggests that right side deafness is related to increased activation of areas involved in processing of degraded input.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
fMRI, Hearing loss, Plasticity, Single-sided deafness, Vestibular schwannoma
in
NeuroImage: Clinical
volume
24
publisher
Elsevier
external identifiers
  • scopus:85070550655
ISSN
2213-1582
DOI
10.1016/j.nicl.2019.101969
language
English
LU publication?
yes
id
ec597a19-0dab-43a9-a9f8-ed45e14a32a3
date added to LUP
2019-08-27 09:37:48
date last changed
2019-09-17 04:59:27
@article{ec597a19-0dab-43a9-a9f8-ed45e14a32a3,
  abstract     = {<p>Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in normal hearing controls. We hypothesised that the response to monaural stimulation in both normal hearing subjects and persons with single-sided deafness would vary with the complexity and nature of the stimuli and the side of stimulation. Design: Patients with left- and right single-sided deafness and controls with normal hearing receiving either binaural or monaural stimuli were tested using speech and non-speech auditory stimuli in an event-related fMRI experiment. Study sample: Twenty-two patients with single-sided deafness after treatment for vestibular schwannoma and 50 normal hearing controls. Results: Normal hearing persons receiving right side monaural stimuli activate bilateral temporal regions. Activation following left side monaural stimulation is more right lateralized. Persons with single-sided deafness respond similarly to controls to monaural stimulation. Persons with right side single-sided deafness show activation of frontal cortical regions not seen in persons with left side single-sided deafness following speech stimuli. This is possibly related to increased effort and more frequently reported problems with communication. Right side single-sided deafness is related to increased activation of areas usually related to processing of degraded input, including the thalamus. Conclusion: Hemispheric dominance following monaural auditory stimulation is modulated by the spectral-temporal properties of the stimuli and by which ear is stimulated. Differences between patients with right- and left side deafness suggests that right side deafness is related to increased activation of areas involved in processing of degraded input.</p>},
  articleno    = {101969},
  author       = {Heggdal, Peder O.Laugen and Aarstad, Hans Jørgen and Brännström, J. and Vassbotn, Flemming S. and Specht, Karsten},
  issn         = {2213-1582},
  keyword      = {fMRI,Hearing loss,Plasticity,Single-sided deafness,Vestibular schwannoma},
  language     = {eng},
  publisher    = {Elsevier},
  series       = {NeuroImage: Clinical},
  title        = {An fMRI-study on single-sided deafness : Spectral-temporal properties and side of stimulation modulates hemispheric dominance},
  url          = {http://dx.doi.org/10.1016/j.nicl.2019.101969},
  volume       = {24},
  year         = {2019},
}