An fMRI-study on single-sided deafness : Spectral-temporal properties and side of stimulation modulates hemispheric dominance
(2019) In NeuroImage: Clinical 24.- Abstract
Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in normal hearing controls. We hypothesised that the response to monaural stimulation in both normal hearing subjects and persons with single-sided deafness would vary with the complexity and nature of the stimuli and the side of stimulation. Design: Patients with left- and right single-sided deafness and controls with normal hearing receiving either binaural or monaural stimuli were tested using speech and non-speech auditory stimuli in an event-related fMRI experiment. Study sample: Twenty-two patients with single-sided... (More)
Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in normal hearing controls. We hypothesised that the response to monaural stimulation in both normal hearing subjects and persons with single-sided deafness would vary with the complexity and nature of the stimuli and the side of stimulation. Design: Patients with left- and right single-sided deafness and controls with normal hearing receiving either binaural or monaural stimuli were tested using speech and non-speech auditory stimuli in an event-related fMRI experiment. Study sample: Twenty-two patients with single-sided deafness after treatment for vestibular schwannoma and 50 normal hearing controls. Results: Normal hearing persons receiving right side monaural stimuli activate bilateral temporal regions. Activation following left side monaural stimulation is more right lateralized. Persons with single-sided deafness respond similarly to controls to monaural stimulation. Persons with right side single-sided deafness show activation of frontal cortical regions not seen in persons with left side single-sided deafness following speech stimuli. This is possibly related to increased effort and more frequently reported problems with communication. Right side single-sided deafness is related to increased activation of areas usually related to processing of degraded input, including the thalamus. Conclusion: Hemispheric dominance following monaural auditory stimulation is modulated by the spectral-temporal properties of the stimuli and by which ear is stimulated. Differences between patients with right- and left side deafness suggests that right side deafness is related to increased activation of areas involved in processing of degraded input.
(Less)
- author
- Heggdal, Peder O.Laugen ; Aarstad, Hans Jørgen ; Brännström, J. LU ; Vassbotn, Flemming S. and Specht, Karsten
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- fMRI, Hearing loss, Plasticity, Single-sided deafness, Vestibular schwannoma
- in
- NeuroImage: Clinical
- volume
- 24
- article number
- 101969
- publisher
- Elsevier
- external identifiers
-
- scopus:85070550655
- pmid:31419767
- ISSN
- 2213-1582
- DOI
- 10.1016/j.nicl.2019.101969
- language
- English
- LU publication?
- yes
- id
- ec597a19-0dab-43a9-a9f8-ed45e14a32a3
- date added to LUP
- 2019-08-27 09:37:48
- date last changed
- 2024-04-30 19:22:50
@article{ec597a19-0dab-43a9-a9f8-ed45e14a32a3,
abstract = {{<p>Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in normal hearing controls. We hypothesised that the response to monaural stimulation in both normal hearing subjects and persons with single-sided deafness would vary with the complexity and nature of the stimuli and the side of stimulation. Design: Patients with left- and right single-sided deafness and controls with normal hearing receiving either binaural or monaural stimuli were tested using speech and non-speech auditory stimuli in an event-related fMRI experiment. Study sample: Twenty-two patients with single-sided deafness after treatment for vestibular schwannoma and 50 normal hearing controls. Results: Normal hearing persons receiving right side monaural stimuli activate bilateral temporal regions. Activation following left side monaural stimulation is more right lateralized. Persons with single-sided deafness respond similarly to controls to monaural stimulation. Persons with right side single-sided deafness show activation of frontal cortical regions not seen in persons with left side single-sided deafness following speech stimuli. This is possibly related to increased effort and more frequently reported problems with communication. Right side single-sided deafness is related to increased activation of areas usually related to processing of degraded input, including the thalamus. Conclusion: Hemispheric dominance following monaural auditory stimulation is modulated by the spectral-temporal properties of the stimuli and by which ear is stimulated. Differences between patients with right- and left side deafness suggests that right side deafness is related to increased activation of areas involved in processing of degraded input.</p>}},
author = {{Heggdal, Peder O.Laugen and Aarstad, Hans Jørgen and Brännström, J. and Vassbotn, Flemming S. and Specht, Karsten}},
issn = {{2213-1582}},
keywords = {{fMRI; Hearing loss; Plasticity; Single-sided deafness; Vestibular schwannoma}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{NeuroImage: Clinical}},
title = {{An fMRI-study on single-sided deafness : Spectral-temporal properties and side of stimulation modulates hemispheric dominance}},
url = {{http://dx.doi.org/10.1016/j.nicl.2019.101969}},
doi = {{10.1016/j.nicl.2019.101969}},
volume = {{24}},
year = {{2019}},
}