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Hormone status in occupational toluene exposure

Svensson, B G ; Nise, G ; Erfurth, E M LU ; Nilsson, A and Skerfving, S LU (1992) In American Journal of Industrial Medicine 22(1). p.99-107
Abstract

Twenty toluene-exposed rotogravure printers, without signs of solvent-induced toxic encephalopathy, had lower median plasma levels of follicle stimulating hormone (FSH) (3.2 vs. 4.9 IU/L; p = .02) and luteinizing hormone (LH) (6.4 vs. 7.2 IU/L; p = .05) and also lower serum levels of free testosterone (7.8 vs. 86.8 pmol/L; p = .05), respectively, than 44 unexposed referents. The individual time-weighted toluene levels in air were 36 (median; range 8-111) ppm. The printers' median toluene levels in blood were 1.7 (1.0-6.6) mumol/l, and in subcutaneous adipose tissue 5.7 (2.5-21) mg/kg fat. There was a negative association between blood toluene and plasma levels of prolactin. In eight printers, the levels of FSH and LH increased during a... (More)

Twenty toluene-exposed rotogravure printers, without signs of solvent-induced toxic encephalopathy, had lower median plasma levels of follicle stimulating hormone (FSH) (3.2 vs. 4.9 IU/L; p = .02) and luteinizing hormone (LH) (6.4 vs. 7.2 IU/L; p = .05) and also lower serum levels of free testosterone (7.8 vs. 86.8 pmol/L; p = .05), respectively, than 44 unexposed referents. The individual time-weighted toluene levels in air were 36 (median; range 8-111) ppm. The printers' median toluene levels in blood were 1.7 (1.0-6.6) mumol/l, and in subcutaneous adipose tissue 5.7 (2.5-21) mg/kg fat. There was a negative association between blood toluene and plasma levels of prolactin. In eight printers, the levels of FSH and LH increased during a 4 week vacation, while the levels of thyroid stimulating hormone, free triiodothyronine, and free thyroxine decreased during the same period. The results indicate a slight, reversible effect of toluene on the cortical level or on the hypothalamic-pituitary axis at exposures well below the permissible levels, possibly mediated through an effect on catecholamine neurotransmission.

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Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipose Tissue/chemistry, Adult, Air Pollutants, Occupational/adverse effects, Follicle Stimulating Hormone/blood, Humans, Luteinizing Hormone/blood, Male, Middle Aged, Occupational Exposure/adverse effects, Printing, Prolactin/blood, Testosterone/blood, Thyrotropin/blood, Toluene/adverse effects
in
American Journal of Industrial Medicine
volume
22
issue
1
pages
99 - 107
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:0026748680
  • pmid:1415282
ISSN
0271-3586
DOI
10.1002/ajim.4700220109
language
English
LU publication?
no
id
ecc53257-aa5d-4ad6-b98e-e2d9631ff743
date added to LUP
2023-11-27 10:38:32
date last changed
2024-01-10 11:54:28
@article{ecc53257-aa5d-4ad6-b98e-e2d9631ff743,
  abstract     = {{<p>Twenty toluene-exposed rotogravure printers, without signs of solvent-induced toxic encephalopathy, had lower median plasma levels of follicle stimulating hormone (FSH) (3.2 vs. 4.9 IU/L; p = .02) and luteinizing hormone (LH) (6.4 vs. 7.2 IU/L; p = .05) and also lower serum levels of free testosterone (7.8 vs. 86.8 pmol/L; p = .05), respectively, than 44 unexposed referents. The individual time-weighted toluene levels in air were 36 (median; range 8-111) ppm. The printers' median toluene levels in blood were 1.7 (1.0-6.6) mumol/l, and in subcutaneous adipose tissue 5.7 (2.5-21) mg/kg fat. There was a negative association between blood toluene and plasma levels of prolactin. In eight printers, the levels of FSH and LH increased during a 4 week vacation, while the levels of thyroid stimulating hormone, free triiodothyronine, and free thyroxine decreased during the same period. The results indicate a slight, reversible effect of toluene on the cortical level or on the hypothalamic-pituitary axis at exposures well below the permissible levels, possibly mediated through an effect on catecholamine neurotransmission.</p>}},
  author       = {{Svensson, B G and Nise, G and Erfurth, E M and Nilsson, A and Skerfving, S}},
  issn         = {{0271-3586}},
  keywords     = {{Adipose Tissue/chemistry; Adult; Air Pollutants, Occupational/adverse effects; Follicle Stimulating Hormone/blood; Humans; Luteinizing Hormone/blood; Male; Middle Aged; Occupational Exposure/adverse effects; Printing; Prolactin/blood; Testosterone/blood; Thyrotropin/blood; Toluene/adverse effects}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{99--107}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{American Journal of Industrial Medicine}},
  title        = {{Hormone status in occupational toluene exposure}},
  url          = {{http://dx.doi.org/10.1002/ajim.4700220109}},
  doi          = {{10.1002/ajim.4700220109}},
  volume       = {{22}},
  year         = {{1992}},
}