Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine.
Åkesson, Kristina LU ; Tenne, Max LU ; Gerdhem, Paul LU ; Luthman, Holger LU and McGuigan, Fiona LU
(2015)
In Journal of Bone and Mineral Metabolism
33(1).
p.9-15
- Abstract
- In the elderly, degenerative changes in the lumbar spine are common, contributing to falsely elevated bone mineral density (BMD) values. The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women. The study included 1,004 Swedish women aged 75 years from the population-based OPRA cohort who attended follow-up at 5 and 10 years. Lumbar spine BMD was assessed by dual energy X-ray absorptiometry (DXA) and each individual vertebra was evaluated visually on the DXA image for apparent degenerative manifestations. Six SNPs in... (More)
- In the elderly, degenerative changes in the lumbar spine are common, contributing to falsely elevated bone mineral density (BMD) values. The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women. The study included 1,004 Swedish women aged 75 years from the population-based OPRA cohort who attended follow-up at 5 and 10 years. Lumbar spine BMD was assessed by dual energy X-ray absorptiometry (DXA) and each individual vertebra was evaluated visually on the DXA image for apparent degenerative manifestations. Six SNPs in PTH and 3 SNPs each in PTH1R, PTH2R and PTHLH were analysed. Among women with degenerative manifestations at the lumbar spine, there was an over-representation at baseline of those carrying the PTH2R SNP rs897083 A-allele (p = 0.0021; odds ratio 1.5 95 % CI 1.2-2.0) and across the duration of follow-up (p = 0.0008). No association was observed between degenerative manifestations and variation in the other genes. None of the PTH hormone system genes were associated with vertebral fracture. Variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4292300
- author
- Åkesson, Kristina
LU
; Tenne, Max
LU
; Gerdhem, Paul
LU
; Luthman, Holger
LU
and McGuigan, Fiona
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Bone and Mineral Metabolism
- volume
- 33
- issue
- 1
- pages
- 9 - 15
- publisher
- Springer
- external identifiers
-
- pmid:24378925
- wos:000347407900002
- pmid:24378925
- scopus:84890979129
- ISSN
- 0914-8779
- DOI
- 10.1007/s00774-013-0550-x
- language
- English
- LU publication?
- yes
- id
- ed586815-a5e7-43c1-8ba5-864f78a3e461 (old id 4292300)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24378925?dopt=Abstract
- date added to LUP
- 2016-04-01 10:57:52
- date last changed
- 2024-05-06 01:51:48
@article{ed586815-a5e7-43c1-8ba5-864f78a3e461,
abstract = {{In the elderly, degenerative changes in the lumbar spine are common, contributing to falsely elevated bone mineral density (BMD) values. The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women. The study included 1,004 Swedish women aged 75 years from the population-based OPRA cohort who attended follow-up at 5 and 10 years. Lumbar spine BMD was assessed by dual energy X-ray absorptiometry (DXA) and each individual vertebra was evaluated visually on the DXA image for apparent degenerative manifestations. Six SNPs in PTH and 3 SNPs each in PTH1R, PTH2R and PTHLH were analysed. Among women with degenerative manifestations at the lumbar spine, there was an over-representation at baseline of those carrying the PTH2R SNP rs897083 A-allele (p = 0.0021; odds ratio 1.5 95 % CI 1.2-2.0) and across the duration of follow-up (p = 0.0008). No association was observed between degenerative manifestations and variation in the other genes. None of the PTH hormone system genes were associated with vertebral fracture. Variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine.}},
author = {{Åkesson, Kristina and Tenne, Max and Gerdhem, Paul and Luthman, Holger and McGuigan, Fiona}},
issn = {{0914-8779}},
language = {{eng}},
number = {{1}},
pages = {{9--15}},
publisher = {{Springer}},
series = {{Journal of Bone and Mineral Metabolism}},
title = {{Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine.}},
url = {{https://lup.lub.lu.se/search/files/2270375/4610131.pdf}},
doi = {{10.1007/s00774-013-0550-x}},
volume = {{33}},
year = {{2015}},
}