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Lack of glutathione transferase activity in intermittent claudication

Pessah-Rasmussen, H LU ; Stavenow, L.; Seidegard, J; Solem, J O LU and Israelsson, B LU (1990) In International Angiology 9(2). p.4-70
Abstract

Glutathione transferase activity towards trans-stilbene oxide (GT-tSBO), an enzyme involved in the detoxification of many substances such as polycyclic aromatic hydrocarbons, was studied in 77 consecutive patients operated with coronary bypass, 73 patients with intermittent claudication, 78 healthy smokers and in 38 healthy non-smokers. The mean ages of these groups were similar. Lack of GT-tSBO was recorded in 45% of coronary bypass patients, in 39% of smoking coronary bypass patients, in 61% of patients with intermittent claudication, in 41% of healthy smokers and in 31% of healthy non-smokers. The lack of GT-tSBO was significantly more frequent among patients with intermittent claudication compared to healthy non-smokers (p less than... (More)

Glutathione transferase activity towards trans-stilbene oxide (GT-tSBO), an enzyme involved in the detoxification of many substances such as polycyclic aromatic hydrocarbons, was studied in 77 consecutive patients operated with coronary bypass, 73 patients with intermittent claudication, 78 healthy smokers and in 38 healthy non-smokers. The mean ages of these groups were similar. Lack of GT-tSBO was recorded in 45% of coronary bypass patients, in 39% of smoking coronary bypass patients, in 61% of patients with intermittent claudication, in 41% of healthy smokers and in 31% of healthy non-smokers. The lack of GT-tSBO was significantly more frequent among patients with intermittent claudication compared to healthy non-smokers (p less than 0.01) and healthy smokers (p less than 0.025) and to smoking coronary bypass. It is concluded that the lack of GT-tSBO is found more frequently among patients with intermittent claudication and this might contribute to explain the sensitivity to smoking among these subjects.

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organization
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Contribution to journal
publication status
published
subject
keywords
Angina Pectoris, Coronary Artery Bypass, Female, Glutathione Transferase, Humans, Intermittent Claudication, Male, Middle Aged, Smoking, Stilbenes, Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
in
International Angiology
volume
9
issue
2
pages
4 - 70
publisher
Minerva Medica
external identifiers
  • scopus:0025037475
ISSN
0392-9590
language
English
LU publication?
yes
id
ed61301a-7ecc-4131-9e16-4f7b8a53eca8
date added to LUP
2017-08-11 16:01:10
date last changed
2017-08-15 16:31:25
@article{ed61301a-7ecc-4131-9e16-4f7b8a53eca8,
  abstract     = {<p>Glutathione transferase activity towards trans-stilbene oxide (GT-tSBO), an enzyme involved in the detoxification of many substances such as polycyclic aromatic hydrocarbons, was studied in 77 consecutive patients operated with coronary bypass, 73 patients with intermittent claudication, 78 healthy smokers and in 38 healthy non-smokers. The mean ages of these groups were similar. Lack of GT-tSBO was recorded in 45% of coronary bypass patients, in 39% of smoking coronary bypass patients, in 61% of patients with intermittent claudication, in 41% of healthy smokers and in 31% of healthy non-smokers. The lack of GT-tSBO was significantly more frequent among patients with intermittent claudication compared to healthy non-smokers (p less than 0.01) and healthy smokers (p less than 0.025) and to smoking coronary bypass. It is concluded that the lack of GT-tSBO is found more frequently among patients with intermittent claudication and this might contribute to explain the sensitivity to smoking among these subjects.</p>},
  author       = {Pessah-Rasmussen, H and Stavenow, L. and Seidegard, J and Solem, J O and Israelsson, B},
  issn         = {0392-9590},
  keyword      = {Angina Pectoris,Coronary Artery Bypass,Female,Glutathione Transferase,Humans,Intermittent Claudication,Male,Middle Aged,Smoking,Stilbenes,Clinical Trial,Comparative Study,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {04},
  number       = {2},
  pages        = {4--70},
  publisher    = {Minerva Medica},
  series       = {International Angiology},
  title        = {Lack of glutathione transferase activity in intermittent claudication},
  volume       = {9},
  year         = {1990},
}