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Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera.

Oddstig, Jenny LU ; Hedeer, Fredrik LU ; Jögi, Jonas LU orcid ; Carlsson, Marcus LU ; Hindorf, Cecilia LU and Engblom, Henrik LU (2013) In Journal of Nuclear Cardiology 20(1). p.38-44
Abstract
BACKGROUND: For a 1-day myocardial perfusion SPECT (MPS) the recommendations for administered activity stated in the EANM guidelines results in an effective dose of up to 16 mSv per patient. Recently, a gamma camera system, based on cadmium zinc telluride (CZT) technology, was introduced. This technique has the potential to reduce the effective dose and scan time compared to the conventional NaI gamma camera. The aim of this study was to investigate if the effective dose can be reduced with a preserved image quality using CZT technology in MPS. METHODS: In total, 150 patients were included in the study. All underwent a 1-day (99m)Tc-tetrofosmin stress-rest protocol and were divided into three subgroups (n = 50 in each group) with 4, 3, and... (More)
BACKGROUND: For a 1-day myocardial perfusion SPECT (MPS) the recommendations for administered activity stated in the EANM guidelines results in an effective dose of up to 16 mSv per patient. Recently, a gamma camera system, based on cadmium zinc telluride (CZT) technology, was introduced. This technique has the potential to reduce the effective dose and scan time compared to the conventional NaI gamma camera. The aim of this study was to investigate if the effective dose can be reduced with a preserved image quality using CZT technology in MPS. METHODS: In total, 150 patients were included in the study. All underwent a 1-day (99m)Tc-tetrofosmin stress-rest protocol and were divided into three subgroups (n = 50 in each group) with 4, 3, and 2.5 MBq/kg body weight of administered activity in the stress examination, respectively. The acquisition time was increased in proportion to the decrease in administered activity. All examinations were analyzed for image quality by visual grading on a 4-point scale (1 = poor, 2 = adequate, 3 = good, 4 = excellent), by two expert readers. RESULTS: The total effective dose (stress + rest) decreased from 9.3 to 5.8 mSv comparing 4 to 2.5 MBq/kg body weight. For the patients undergoing stress examination only (35%) the effective dose, administrating 2.5 MBq/kg, was 1.4 mSv. The image acquisition times for 2.5 MBq/kg body weight were 475 and 300 seconds (stress and rest) compared to 900 seconds for each when using conventional MPS. The average image quality was 3.7 ± 0.5, 3.8 ± 0.5, and 3.8 ± 0.4 for the stress images and 3.5 ± 0.6, 3.6 ± 0.6, and 3.5 ± 0.6 for the rest images and showed no statistically significant difference (P = .62) among the 4, 3, and 2.5 MBq/kg groups. CONCLUSIONS: The new CZT technology can be used to considerably decrease the effective dose and acquisition time for MPS with preserved high image quality. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Cardiology
volume
20
issue
1
pages
38 - 44
publisher
Springer
external identifiers
  • wos:000313806900007
  • pmid:23143809
  • scopus:84872679925
  • pmid:23143809
ISSN
1532-6551
DOI
10.1007/s12350-012-9634-6
language
English
LU publication?
yes
id
ed808c5f-f83b-4c89-b943-8803e6147aad (old id 3219022)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23143809?dopt=Abstract
date added to LUP
2016-04-01 14:15:10
date last changed
2022-03-21 23:01:04
@article{ed808c5f-f83b-4c89-b943-8803e6147aad,
  abstract     = {{BACKGROUND: For a 1-day myocardial perfusion SPECT (MPS) the recommendations for administered activity stated in the EANM guidelines results in an effective dose of up to 16 mSv per patient. Recently, a gamma camera system, based on cadmium zinc telluride (CZT) technology, was introduced. This technique has the potential to reduce the effective dose and scan time compared to the conventional NaI gamma camera. The aim of this study was to investigate if the effective dose can be reduced with a preserved image quality using CZT technology in MPS. METHODS: In total, 150 patients were included in the study. All underwent a 1-day (99m)Tc-tetrofosmin stress-rest protocol and were divided into three subgroups (n = 50 in each group) with 4, 3, and 2.5 MBq/kg body weight of administered activity in the stress examination, respectively. The acquisition time was increased in proportion to the decrease in administered activity. All examinations were analyzed for image quality by visual grading on a 4-point scale (1 = poor, 2 = adequate, 3 = good, 4 = excellent), by two expert readers. RESULTS: The total effective dose (stress + rest) decreased from 9.3 to 5.8 mSv comparing 4 to 2.5 MBq/kg body weight. For the patients undergoing stress examination only (35%) the effective dose, administrating 2.5 MBq/kg, was 1.4 mSv. The image acquisition times for 2.5 MBq/kg body weight were 475 and 300 seconds (stress and rest) compared to 900 seconds for each when using conventional MPS. The average image quality was 3.7 ± 0.5, 3.8 ± 0.5, and 3.8 ± 0.4 for the stress images and 3.5 ± 0.6, 3.6 ± 0.6, and 3.5 ± 0.6 for the rest images and showed no statistically significant difference (P = .62) among the 4, 3, and 2.5 MBq/kg groups. CONCLUSIONS: The new CZT technology can be used to considerably decrease the effective dose and acquisition time for MPS with preserved high image quality.}},
  author       = {{Oddstig, Jenny and Hedeer, Fredrik and Jögi, Jonas and Carlsson, Marcus and Hindorf, Cecilia and Engblom, Henrik}},
  issn         = {{1532-6551}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{38--44}},
  publisher    = {{Springer}},
  series       = {{Journal of Nuclear Cardiology}},
  title        = {{Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera.}},
  url          = {{https://lup.lub.lu.se/search/files/3871426/3683815.pdf}},
  doi          = {{10.1007/s12350-012-9634-6}},
  volume       = {{20}},
  year         = {{2013}},
}