Serum osteocalcin levels at 4 months of age were associated with neurodevelopment at 4 years of age in term-born children
Berggren, Sara LU ; Andersson, Ola LU
; Hellström-Westas, Lena
LU
; Dahlgren, Jovanna
and Roswall, Josefine
(2022)
In Acta Pædiatrica
111(2).
p.338-345
- Abstract
Aim: The hormone osteocalcin influenced neurodevelopment and cognition in mice models; this human study explored potential associations between total serum levels in human infants and neurodevelopment at 4 years of age. Methods: The data were based on two Swedish birth cohorts from 2008 to 2009. We followed 158 healthy full-term vaginal births (51% girls) by measuring serum osteocalcin in cord blood and at 4, 12 and 36 months. The values were compared with neurodevelopment tests at 4 years of age. Results: There was an association between osteocalcin at 4 months and later full-scale intelligence quotient (IQ; r2 0.031, p < 0.05). Children with osteocalcin levels in the highest quartile scored 5.6 (95% confidence interval... (More)
Aim: The hormone osteocalcin influenced neurodevelopment and cognition in mice models; this human study explored potential associations between total serum levels in human infants and neurodevelopment at 4 years of age. Methods: The data were based on two Swedish birth cohorts from 2008 to 2009. We followed 158 healthy full-term vaginal births (51% girls) by measuring serum osteocalcin in cord blood and at 4, 12 and 36 months. The values were compared with neurodevelopment tests at 4 years of age. Results: There was an association between osteocalcin at 4 months and later full-scale intelligence quotient (IQ; r2 0.031, p < 0.05). Children with osteocalcin levels in the highest quartile scored 5.6 (95% confidence interval [1.3, 9.9]) points higher than those in the lowest quartile, with mean scores of 118.8 ± 8.8 and 113.2 ± 9.2 (p < 0.05). They also scored higher on gross motor skills (p < 0.05) and showed greater ability during the drawing trail test (p < 0.005). Cord levels of osteocalcin were negatively associated with processing speed and fine motor development at 4 years, but levels at 12 and 36 months were not associated with later neurodevelopment. Conclusion: Osteocalcin levels in infancy appeared to be associated with later IQ and motor development, but more research is needed.
(Less)
- author
- Berggren, Sara
LU
; Andersson, Ola
LU
; Hellström-Westas, Lena
LU
; Dahlgren, Jovanna
and Roswall, Josefine
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- early childhood, infancy, intelligence quotient, neurodevelopment, osteocalcin
- in
- Acta Pædiatrica
- volume
- 111
- issue
- 2
- pages
- 338 - 345
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:34647329
- scopus:85118828454
- pmid:34647329
- ISSN
- 1651-2227
- DOI
- 10.1111/apa.16151
- language
- English
- LU publication?
- yes
- id
- eda95b03-c94d-4e35-b3aa-30b5ad16868b
- date added to LUP
- 2021-10-18 08:31:20
- date last changed
- 2024-04-20 13:23:52
@article{eda95b03-c94d-4e35-b3aa-30b5ad16868b,
abstract = {{<p>Aim: The hormone osteocalcin influenced neurodevelopment and cognition in mice models; this human study explored potential associations between total serum levels in human infants and neurodevelopment at 4 years of age. Methods: The data were based on two Swedish birth cohorts from 2008 to 2009. We followed 158 healthy full-term vaginal births (51% girls) by measuring serum osteocalcin in cord blood and at 4, 12 and 36 months. The values were compared with neurodevelopment tests at 4 years of age. Results: There was an association between osteocalcin at 4 months and later full-scale intelligence quotient (IQ; r<sup>2</sup> 0.031, p < 0.05). Children with osteocalcin levels in the highest quartile scored 5.6 (95% confidence interval [1.3, 9.9]) points higher than those in the lowest quartile, with mean scores of 118.8 ± 8.8 and 113.2 ± 9.2 (p < 0.05). They also scored higher on gross motor skills (p < 0.05) and showed greater ability during the drawing trail test (p < 0.005). Cord levels of osteocalcin were negatively associated with processing speed and fine motor development at 4 years, but levels at 12 and 36 months were not associated with later neurodevelopment. Conclusion: Osteocalcin levels in infancy appeared to be associated with later IQ and motor development, but more research is needed.</p>}},
author = {{Berggren, Sara and Andersson, Ola and Hellström-Westas, Lena and Dahlgren, Jovanna and Roswall, Josefine}},
issn = {{1651-2227}},
keywords = {{early childhood; infancy; intelligence quotient; neurodevelopment; osteocalcin}},
language = {{eng}},
number = {{2}},
pages = {{338--345}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Pædiatrica}},
title = {{Serum osteocalcin levels at 4 months of age were associated with neurodevelopment at 4 years of age in term-born children}},
url = {{http://dx.doi.org/10.1111/apa.16151}},
doi = {{10.1111/apa.16151}},
volume = {{111}},
year = {{2022}},
}