Reference limits for osteocalcin in infancy and early childhood : A longitudinal birth cohort study
Berggren, Sara S ; Dahlgren, Jovanna ; Andersson, Ola LU
; Bergman, Stefan
LU
and Roswall, Josefine
(2024)
In Clinical Endocrinology
- Abstract
OBJECTIVE: The longitudinal variations in serum levels of the hormone osteocalcin is largely unknown during infancy and early childhood. Our aim was to establish reference limits for total serum osteocalcin during specific time points from birth until 5 years of age and present those in the context of sex, breastfeeding practices and gestational age (GA).
DESIGN: Blood samples from 551 Swedish children were analysed at birth, 4, 12, 36 and 60 months of age. Total serum osteocalcin was measured using the IDS-iSYS N-MID Osteocalcin assay technique. Information about the mother, birth, anthropometrics and a food diary were collected.
RESULTS: Sex-specific and age-specific reference limits were established for the five time... (More)
OBJECTIVE: The longitudinal variations in serum levels of the hormone osteocalcin is largely unknown during infancy and early childhood. Our aim was to establish reference limits for total serum osteocalcin during specific time points from birth until 5 years of age and present those in the context of sex, breastfeeding practices and gestational age (GA).
DESIGN: Blood samples from 551 Swedish children were analysed at birth, 4, 12, 36 and 60 months of age. Total serum osteocalcin was measured using the IDS-iSYS N-MID Osteocalcin assay technique. Information about the mother, birth, anthropometrics and a food diary were collected.
RESULTS: Sex-specific and age-specific reference limits were established for the five time points. The median osteocalcin levels over time were 40.8, 90.0, 67.8, 62.2 and 80.9 μg/L for boys and 38.1, 95.5, 78.3, 73.9 and 92.6 μg/L for girls. Lower GA was associated to higher osteocalcin at birth, and ongoing breastfeeding was associated to higher osteocalcin levels.
CONCLUSION: Osteocalcin followed a wavelike pattern with low levels in the umbilical cord and a postnatal peak during the first year which then declined and rose again by the age of five. Knowledge of this wavelike pattern and association to factors as sex, breastfeeding and GA may help clinicians to interpret individual osteocalcin levels and guide in future research.
(Less)
- author
- Berggren, Sara S
; Dahlgren, Jovanna
; Andersson, Ola
LU
; Bergman, Stefan
LU
and Roswall, Josefine
- organization
- publishing date
- 2024-02-22
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Clinical Endocrinology
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85186415935
- pmid:38385947
- ISSN
- 1365-2265
- DOI
- 10.1111/cen.15036
- language
- English
- LU publication?
- yes
- additional info
- © 2024 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.
- id
- f21c8815-3e52-4f93-89e4-5cbd20ebcfe4
- date added to LUP
- 2024-02-29 14:20:07
- date last changed
- 2024-04-25 11:31:30
@article{f21c8815-3e52-4f93-89e4-5cbd20ebcfe4,
abstract = {{<p>OBJECTIVE: The longitudinal variations in serum levels of the hormone osteocalcin is largely unknown during infancy and early childhood. Our aim was to establish reference limits for total serum osteocalcin during specific time points from birth until 5 years of age and present those in the context of sex, breastfeeding practices and gestational age (GA).</p><p>DESIGN: Blood samples from 551 Swedish children were analysed at birth, 4, 12, 36 and 60 months of age. Total serum osteocalcin was measured using the IDS-iSYS N-MID Osteocalcin assay technique. Information about the mother, birth, anthropometrics and a food diary were collected.</p><p>RESULTS: Sex-specific and age-specific reference limits were established for the five time points. The median osteocalcin levels over time were 40.8, 90.0, 67.8, 62.2 and 80.9 μg/L for boys and 38.1, 95.5, 78.3, 73.9 and 92.6 μg/L for girls. Lower GA was associated to higher osteocalcin at birth, and ongoing breastfeeding was associated to higher osteocalcin levels.</p><p>CONCLUSION: Osteocalcin followed a wavelike pattern with low levels in the umbilical cord and a postnatal peak during the first year which then declined and rose again by the age of five. Knowledge of this wavelike pattern and association to factors as sex, breastfeeding and GA may help clinicians to interpret individual osteocalcin levels and guide in future research.</p>}},
author = {{Berggren, Sara S and Dahlgren, Jovanna and Andersson, Ola and Bergman, Stefan and Roswall, Josefine}},
issn = {{1365-2265}},
language = {{eng}},
month = {{02}},
publisher = {{Wiley-Blackwell}},
series = {{Clinical Endocrinology}},
title = {{Reference limits for osteocalcin in infancy and early childhood : A longitudinal birth cohort study}},
url = {{http://dx.doi.org/10.1111/cen.15036}},
doi = {{10.1111/cen.15036}},
year = {{2024}},
}