Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastases
Vidarsdottir, Halla LU ; Tran, Lena ; Nodin, Björn LU ; Jirström, Karin LU
; Planck, Maria
LU
; Mattsson, Johanna S.M.
; Botling, Johan
; Micke, Patrick
; Jönsson, Per
LU
and Brunnström, Hans
LU
(2018)
In American Journal of Clinical Pathology
150(6).
p.533-544
- Abstract
Objectives: Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis.
Methods: TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases.
Results: Most lung adenocarcinomas, 89%, 93%, and 93%, were positive with TTF-1 clones 8G7G3/1, SPT24, and SP141, respectively. The corresponding figures for lung squamous cell carcinomas were 0%, 6%, and 8%. In total, five (2%), 19 (7%), and 21 (8%) of the pulmonary metastases from colorectal adenocarcinomas were positive with clones 8G7G3/1, SPT24, and... (More)
Objectives: Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis.
Methods: TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases.
Results: Most lung adenocarcinomas, 89%, 93%, and 93%, were positive with TTF-1 clones 8G7G3/1, SPT24, and SP141, respectively. The corresponding figures for lung squamous cell carcinomas were 0%, 6%, and 8%. In total, five (2%), 19 (7%), and 21 (8%) of the pulmonary metastases from colorectal adenocarcinomas were positive with clones 8G7G3/1, SPT24, and SP141, respectively. Other TTF-1-positive pulmonary metastases (n = 8) were thyroid, urothelial, pancreatic, small bowel, and cervix carcinomas.
Conclusions: TTF-1 expression in lung cancer and pulmonary metastases differs between clones, with 8G7G3/1 being more specific but less sensitive compared with SPT24 and SP141.
(Less)
- author
- Vidarsdottir, Halla
LU
; Tran, Lena
; Nodin, Björn
LU
; Jirström, Karin
LU
; Planck, Maria
LU
; Mattsson, Johanna S.M.
; Botling, Johan
; Micke, Patrick
; Jönsson, Per
LU
and Brunnström, Hans
LU
- organization
-
- Improved diagnostics and prognostics of lung cancer and metastases to the lungs (research group)
- Personalized Pathology & Cancer Therapy (research group)
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Research Group Lung Cancer (research group)
- Thoracic Surgery
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Clinical Pathology
- volume
- 150
- issue
- 6
- pages
- 12 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:30169783
- scopus:85055604246
- ISSN
- 1943-7722
- DOI
- 10.1093/ajcp/aqy083
- project
- Histopathological and molecular diagnostics of lung cancer
- language
- English
- LU publication?
- yes
- id
- ee7749c8-23a1-4a20-92ec-5fe1a0c89c14
- date added to LUP
- 2018-11-15 12:01:53
- date last changed
- 2024-06-10 22:27:11
@article{ee7749c8-23a1-4a20-92ec-5fe1a0c89c14,
abstract = {{<p>Objectives: Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis.</p><p>Methods: TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases.</p><p>Results: Most lung adenocarcinomas, 89%, 93%, and 93%, were positive with TTF-1 clones 8G7G3/1, SPT24, and SP141, respectively. The corresponding figures for lung squamous cell carcinomas were 0%, 6%, and 8%. In total, five (2%), 19 (7%), and 21 (8%) of the pulmonary metastases from colorectal adenocarcinomas were positive with clones 8G7G3/1, SPT24, and SP141, respectively. Other TTF-1-positive pulmonary metastases (n = 8) were thyroid, urothelial, pancreatic, small bowel, and cervix carcinomas.</p><p>Conclusions: TTF-1 expression in lung cancer and pulmonary metastases differs between clones, with 8G7G3/1 being more specific but less sensitive compared with SPT24 and SP141.</p>}},
author = {{Vidarsdottir, Halla and Tran, Lena and Nodin, Björn and Jirström, Karin and Planck, Maria and Mattsson, Johanna S.M. and Botling, Johan and Micke, Patrick and Jönsson, Per and Brunnström, Hans}},
issn = {{1943-7722}},
language = {{eng}},
number = {{6}},
pages = {{533--544}},
publisher = {{Oxford University Press}},
series = {{American Journal of Clinical Pathology}},
title = {{Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastases}},
url = {{http://dx.doi.org/10.1093/ajcp/aqy083}},
doi = {{10.1093/ajcp/aqy083}},
volume = {{150}},
year = {{2018}},
}