Intra-operative application of ultra-high frequency ultrasound facilitates differentiation of bowel wall characteristics between ganglionic and aganglionic segments during transanal endorectal pull-through for Hirschsprung disease
Granéli, Christina LU ; Evertsson, Maria LU ; Erlöv, Tobias LU ; Hawez, Tebin LU
; Hagelsteen, Kristine
LU
; Tofft, Louise
LU
; Jansson, Tomas
LU
; Cinthio, Magnus
LU
and Stenström, Pernilla
LU
(2026)
In Communications medicine
6.
p.1-7
- Abstract
BACKGROUND: The hypothesis was that ultra-high-frequency (UHF) ultrasound can distinguish ganglionic from aganglionic bowel during surgery for Hirschsprung disease. The aim was to assess UHF ultrasound for differentiating ganglionosis from aganglionosis in children undergoing rectosigmoid Hirschsprung disease surgery.
METHODS: The child's intestine was examined intra-operatively using the Vevo MD (Fujifilm VisualSonics, Toronto, ON, Canada) system equipped with the UHF70 transducer; 50 MHz in center frequency. Collected images were analyzed and results presented as median.
RESULTS: Twenty-one patients were examined intra-operatively with UHF ultrasound. The muscularis interna was thicker in ganglionic bowel compared to... (More)
BACKGROUND: The hypothesis was that ultra-high-frequency (UHF) ultrasound can distinguish ganglionic from aganglionic bowel during surgery for Hirschsprung disease. The aim was to assess UHF ultrasound for differentiating ganglionosis from aganglionosis in children undergoing rectosigmoid Hirschsprung disease surgery.
METHODS: The child's intestine was examined intra-operatively using the Vevo MD (Fujifilm VisualSonics, Toronto, ON, Canada) system equipped with the UHF70 transducer; 50 MHz in center frequency. Collected images were analyzed and results presented as median.
RESULTS: Twenty-one patients were examined intra-operatively with UHF ultrasound. The muscularis interna was thicker in ganglionic bowel compared to aganglionic: 0.298 vs 0.599 (p < 0.001), and the ratio of the muscularis interna/muscularis externa was greater; 0.621 vs 1.225 (p < 0.001). The echogenicity was higher, i.e., whiter, in the aganglionic submucosa 104.5 vs 81.6 (p < 0.016).
CONCLUSION: The use of intra-operative UHF ultrasound shows great promise in the determination of ganglionic versus aganglionic bowel.
(Less)
- author
- Granéli, Christina
LU
; Evertsson, Maria
LU
; Erlöv, Tobias
LU
; Hawez, Tebin
LU
; Hagelsteen, Kristine
LU
; Tofft, Louise
LU
; Jansson, Tomas
LU
; Cinthio, Magnus
LU
and Stenström, Pernilla
LU
- organization
-
- Pediatric surgery (research group)
- Biomedical Ultrasound (research group)
- LU Profile Area: Light and Materials
- LTH Profile Area: Engineering Health
- Medical ultrasound (research group)
- Lund Laser Centre, LLC
- LTH Profile Area: Photon Science and Technology
- Medicon Bridge (research group)
- Biomedical Engineering (M.Sc.Eng.)
- Department of Clinical Sciences, Lund
- publishing date
- 2026-05-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Communications medicine
- volume
- 6
- article number
- 272
- pages
- 1 - 7
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:105046256553
- pmid:42098247
- ISSN
- 2730-664X
- DOI
- 10.1038/s43856-026-01632-4
- language
- English
- LU publication?
- yes
- additional info
- © 2026. The Author(s).
- id
- ef335d59-59fe-4b65-a77e-f4c1aa9bf106
- date added to LUP
- 2026-08-24 08:42:05
- date last changed
- 2026-09-08 04:47:08
@article{ef335d59-59fe-4b65-a77e-f4c1aa9bf106,
abstract = {{<p>BACKGROUND: The hypothesis was that ultra-high-frequency (UHF) ultrasound can distinguish ganglionic from aganglionic bowel during surgery for Hirschsprung disease. The aim was to assess UHF ultrasound for differentiating ganglionosis from aganglionosis in children undergoing rectosigmoid Hirschsprung disease surgery.</p><p>METHODS: The child's intestine was examined intra-operatively using the Vevo MD (Fujifilm VisualSonics, Toronto, ON, Canada) system equipped with the UHF70 transducer; 50 MHz in center frequency. Collected images were analyzed and results presented as median.</p><p>RESULTS: Twenty-one patients were examined intra-operatively with UHF ultrasound. The muscularis interna was thicker in ganglionic bowel compared to aganglionic: 0.298 vs 0.599 (p < 0.001), and the ratio of the muscularis interna/muscularis externa was greater; 0.621 vs 1.225 (p < 0.001). The echogenicity was higher, i.e., whiter, in the aganglionic submucosa 104.5 vs 81.6 (p < 0.016).</p><p>CONCLUSION: The use of intra-operative UHF ultrasound shows great promise in the determination of ganglionic versus aganglionic bowel.</p>}},
author = {{Granéli, Christina and Evertsson, Maria and Erlöv, Tobias and Hawez, Tebin and Hagelsteen, Kristine and Tofft, Louise and Jansson, Tomas and Cinthio, Magnus and Stenström, Pernilla}},
issn = {{2730-664X}},
language = {{eng}},
month = {{05}},
pages = {{1--7}},
publisher = {{Nature Publishing Group}},
series = {{Communications medicine}},
title = {{Intra-operative application of ultra-high frequency ultrasound facilitates differentiation of bowel wall characteristics between ganglionic and aganglionic segments during transanal endorectal pull-through for Hirschsprung disease}},
url = {{http://dx.doi.org/10.1038/s43856-026-01632-4}},
doi = {{10.1038/s43856-026-01632-4}},
volume = {{6}},
year = {{2026}},
}