Addition of cultured Schwann cells to tendon autografts and freeze-thawed muscle grafts improves peripheral nerve regeneration
Nishiura, Y ; Brandt, Jerker LU ; Nilsson, Anna LU ; Kanje, Martin LU and Dahlin, Lars LU
(2004)
In Tissue Engineering
10(1-2).
p.157-164
- Abstract
- The effects of addition of Schwann cells on peripheral nerve regeneration through a novel graft material-the tendon autograft-and a conventional freeze-thawed muscle graft, were studied in the rat sciatic nerve. Adult Schwann cell cultures were established from predegenerated nerves. The Schwann cells were added to the autologous grafts by coculture (tendon autograft) or injection (freeze-thawed muscle graft). Both graft types supported adherence of the added Schwann cells. Addition of cultured Schwann cells to the two different graft models improved regeneration by increasing the rate of axonal outgrowth as compared with similar grafts without added cells.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/286870
- author
- Nishiura, Y
; Brandt, Jerker
LU
; Nilsson, Anna
LU
; Kanje, Martin
LU
and Dahlin, Lars
LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Tissue Engineering
- volume
- 10
- issue
- 1-2
- pages
- 157 - 164
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- wos:000189028600017
- scopus:1042266505
- ISSN
- 1076-3279
- language
- English
- LU publication?
- yes
- id
- ef609c67-1412-45e8-b270-14db425fc21c (old id 286870)
- date added to LUP
- 2016-04-01 16:15:33
- date last changed
- 2022-01-28 18:28:31
@article{ef609c67-1412-45e8-b270-14db425fc21c,
abstract = {{The effects of addition of Schwann cells on peripheral nerve regeneration through a novel graft material-the tendon autograft-and a conventional freeze-thawed muscle graft, were studied in the rat sciatic nerve. Adult Schwann cell cultures were established from predegenerated nerves. The Schwann cells were added to the autologous grafts by coculture (tendon autograft) or injection (freeze-thawed muscle graft). Both graft types supported adherence of the added Schwann cells. Addition of cultured Schwann cells to the two different graft models improved regeneration by increasing the rate of axonal outgrowth as compared with similar grafts without added cells.}},
author = {{Nishiura, Y and Brandt, Jerker and Nilsson, Anna and Kanje, Martin and Dahlin, Lars}},
issn = {{1076-3279}},
language = {{eng}},
number = {{1-2}},
pages = {{157--164}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Tissue Engineering}},
title = {{Addition of cultured Schwann cells to tendon autografts and freeze-thawed muscle grafts improves peripheral nerve regeneration}},
volume = {{10}},
year = {{2004}},
}