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Time Course of Classically Conditioned Purkinje Cell Response is Determined by Initial Part of Conditioned Stimulus

Jirenhed, Dan-Anders LU and Hesslow, Germund LU (2011) In Journal of Neuroscience 31(25). p.9070-9074
Abstract
Classical conditioning of a motor response such as eyeblink is associated with the development of a pause in cerebellar Purkinje cell firing that is probably an important driver of the overt response. This conditioned Purkinje cell response is adaptively timed and has a specific temporal profile that probably explains the time course of the overt behavior. It is generally assumed that the temporal properties of the conditioned Purkinje cell response are determined by the temporal pattern of the parallel fiber impulses generated by the conditioned stimulus at the time of the conditioned response. We show here in the decerebrate ferret preparation that a very brief conditioned stimulus, consisting of only one or two impulses in the mossy... (More)
Classical conditioning of a motor response such as eyeblink is associated with the development of a pause in cerebellar Purkinje cell firing that is probably an important driver of the overt response. This conditioned Purkinje cell response is adaptively timed and has a specific temporal profile that probably explains the time course of the overt behavior. It is generally assumed that the temporal properties of the conditioned Purkinje cell response are determined by the temporal pattern of the parallel fiber impulses generated by the conditioned stimulus at the time of the conditioned response. We show here in the decerebrate ferret preparation that a very brief conditioned stimulus, consisting of only one or two impulses in the mossy fibers, can be sufficient to elicit a full conditioned Purkinje cell response with normal time course. The finding suggests that parallel fiber input to the Purkinje cell influences the firing rate several hundred milliseconds later. It poses a serious challenge to the standard view of the role of parallel fiber impulses in response timing. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Purkinje cell – Classical Conditioning – Temporal coding - Cerebellum – Motor learning – Eyeblink - Ferret
in
Journal of Neuroscience
volume
31
issue
25
pages
9070 - 9074
publisher
Society for Neuroscience
external identifiers
  • pmid:21697357
  • wos:000291980500002
  • scopus:79959642757
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.1653-11.2011
project
Cognition, Communication and Learning
language
English
LU publication?
yes
id
ef96a512-b7c6-43bc-be61-709697773318 (old id 1917429)
date added to LUP
2011-07-11 09:16:31
date last changed
2017-01-08 04:37:14
@article{ef96a512-b7c6-43bc-be61-709697773318,
  abstract     = {Classical conditioning of a motor response such as eyeblink is associated with the development of a pause in cerebellar Purkinje cell firing that is probably an important driver of the overt response. This conditioned Purkinje cell response is adaptively timed and has a specific temporal profile that probably explains the time course of the overt behavior. It is generally assumed that the temporal properties of the conditioned Purkinje cell response are determined by the temporal pattern of the parallel fiber impulses generated by the conditioned stimulus at the time of the conditioned response. We show here in the decerebrate ferret preparation that a very brief conditioned stimulus, consisting of only one or two impulses in the mossy fibers, can be sufficient to elicit a full conditioned Purkinje cell response with normal time course. The finding suggests that parallel fiber input to the Purkinje cell influences the firing rate several hundred milliseconds later. It poses a serious challenge to the standard view of the role of parallel fiber impulses in response timing.},
  author       = {Jirenhed, Dan-Anders and Hesslow, Germund},
  issn         = {1529-2401},
  keyword      = {Purkinje cell – Classical Conditioning – Temporal coding - Cerebellum – Motor learning – Eyeblink - Ferret},
  language     = {eng},
  number       = {25},
  pages        = {9070--9074},
  publisher    = {Society for Neuroscience},
  series       = {Journal of Neuroscience},
  title        = {Time Course of Classically Conditioned Purkinje Cell Response is Determined by Initial Part of Conditioned Stimulus},
  url          = {http://dx.doi.org/10.1523/JNEUROSCI.1653-11.2011},
  volume       = {31},
  year         = {2011},
}