Trisomy 5 and t(5;14)(q11;q32) as the sole abnormalities in two different clones from a centroblastic non-Hodgkin's lymphoma
Kristoffersson, Ulf LU ; Heim, Sverre LU ; Mandahl, Nils LU ; Olsson, Håkan LU
; Åkerman, Måns
LU
and Mitelman, Felix
LU
(1988)
In Cancer Genetics and Cytogenetics
36(2).
p.173-176
- Abstract
A 62-year-old previously healthy woman presented with a centroblastic non-Hodgkin's lymphoma in the thyroid. Chromosome analysis revealed two unrelated clones, 47,XX,+5 and 46,XX,-14,+der(14)t(5;14)(q11;q32). The two clones may reflect a polyclonal origin, or they may be the descendants of the same neoplastically rearranged cell. In the latter case, the clonal aberrations are either secondary to an event detectable only at the molecular level, or one of them is a primary cytogenetic event while the other arose through clonal evolution with loss of the primary aberration. The best candidate for the primary change would be trisomy 5. Trisomy 5 has previously been associated with lymphomas with diffuse, large, noncleaved morphology, a... (More)
A 62-year-old previously healthy woman presented with a centroblastic non-Hodgkin's lymphoma in the thyroid. Chromosome analysis revealed two unrelated clones, 47,XX,+5 and 46,XX,-14,+der(14)t(5;14)(q11;q32). The two clones may reflect a polyclonal origin, or they may be the descendants of the same neoplastically rearranged cell. In the latter case, the clonal aberrations are either secondary to an event detectable only at the molecular level, or one of them is a primary cytogenetic event while the other arose through clonal evolution with loss of the primary aberration. The best candidate for the primary change would be trisomy 5. Trisomy 5 has previously been associated with lymphomas with diffuse, large, noncleaved morphology, a group within the Working Formulation largely equivalent to centroblastic lymphomas in the Kiel classification. Our findings thus support the notion that trisomy 5 may be associated with centroblastic/diffuse, large, noncleaved lymphomas.
(Less)
- author
- Kristoffersson, Ulf
LU
; Heim, Sverre
LU
; Mandahl, Nils
LU
; Olsson, Håkan
LU
; Åkerman, Måns
LU
and Mitelman, Felix
LU
- organization
- publishing date
- 1988-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Genetics and Cytogenetics
- volume
- 36
- issue
- 2
- pages
- 173 - 176
- publisher
- Elsevier
- external identifiers
-
- pmid:3203305
- scopus:0024253798
- ISSN
- 0165-4608
- DOI
- 10.1016/0165-4608(88)90141-0
- language
- English
- LU publication?
- yes
- id
- efed550d-3b70-40c5-8258-33925c80a3fe
- date added to LUP
- 2018-12-18 13:25:53
- date last changed
- 2024-01-15 10:09:06
@article{efed550d-3b70-40c5-8258-33925c80a3fe,
abstract = {{<p>A 62-year-old previously healthy woman presented with a centroblastic non-Hodgkin's lymphoma in the thyroid. Chromosome analysis revealed two unrelated clones, 47,XX,+5 and 46,XX,-14,+der(14)t(5;14)(q11;q32). The two clones may reflect a polyclonal origin, or they may be the descendants of the same neoplastically rearranged cell. In the latter case, the clonal aberrations are either secondary to an event detectable only at the molecular level, or one of them is a primary cytogenetic event while the other arose through clonal evolution with loss of the primary aberration. The best candidate for the primary change would be trisomy 5. Trisomy 5 has previously been associated with lymphomas with diffuse, large, noncleaved morphology, a group within the Working Formulation largely equivalent to centroblastic lymphomas in the Kiel classification. Our findings thus support the notion that trisomy 5 may be associated with centroblastic/diffuse, large, noncleaved lymphomas.</p>}},
author = {{Kristoffersson, Ulf and Heim, Sverre and Mandahl, Nils and Olsson, Håkan and Åkerman, Måns and Mitelman, Felix}},
issn = {{0165-4608}},
language = {{eng}},
month = {{01}},
number = {{2}},
pages = {{173--176}},
publisher = {{Elsevier}},
series = {{Cancer Genetics and Cytogenetics}},
title = {{Trisomy 5 and t(5;14)(q11;q32) as the sole abnormalities in two different clones from a centroblastic non-Hodgkin's lymphoma}},
url = {{http://dx.doi.org/10.1016/0165-4608(88)90141-0}},
doi = {{10.1016/0165-4608(88)90141-0}},
volume = {{36}},
year = {{1988}},
}