Demonstration of antibodies binding to autologous and allogeneic leukemic cells in childhood ALL - Evidence for a common ALL antigen(s)
(1986) In Blut 52(6). p.337-343- Abstract
The humoral immune response to autologous leukemic cells was investigated in childhood ALL using a 125I protein A binding assay. In 5/7 patients antibodies were demonstrated at diagnosis and in 3/7 cases also after chemotherapy. Sera from 2/3 patients, which bound significantly to autologous leukemic cells, did not bind significantly to autologous remission cells. In allogeneic experiments sera bound significantly to ALL leukemic cells (6/7 positive combinations), but not to AML leukemic cells (8/8 negative combinations). We propose that ALL sera contain antibodies binding to autologous leukemic cells and that they are directed against a common ALL antigen(s).
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https://lup.lub.lu.se/record/f04422f3-ad49-4b64-b068-169be4fb25c4
- author
- Fäldt, R. LU ; Ankerst, J. LU and Garwicz, S. LU
- organization
- publishing date
- 1986-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- I protein A binding assay, Acute lymphoblastic leukemia, Antibodies
- in
- Blut
- volume
- 52
- issue
- 6
- pages
- 337 - 343
- publisher
- Springer
- external identifiers
-
- scopus:0022599273
- pmid:2941087
- ISSN
- 0006-5242
- DOI
- 10.1007/BF00320780
- language
- English
- LU publication?
- yes
- id
- f04422f3-ad49-4b64-b068-169be4fb25c4
- date added to LUP
- 2021-01-07 16:10:04
- date last changed
- 2024-01-03 03:08:39
@article{f04422f3-ad49-4b64-b068-169be4fb25c4, abstract = {{<p>The humoral immune response to autologous leukemic cells was investigated in childhood ALL using a <sup>125</sup>I protein A binding assay. In 5/7 patients antibodies were demonstrated at diagnosis and in 3/7 cases also after chemotherapy. Sera from 2/3 patients, which bound significantly to autologous leukemic cells, did not bind significantly to autologous remission cells. In allogeneic experiments sera bound significantly to ALL leukemic cells (6/7 positive combinations), but not to AML leukemic cells (8/8 negative combinations). We propose that ALL sera contain antibodies binding to autologous leukemic cells and that they are directed against a common ALL antigen(s).</p>}}, author = {{Fäldt, R. and Ankerst, J. and Garwicz, S.}}, issn = {{0006-5242}}, keywords = {{I protein A binding assay; Acute lymphoblastic leukemia; Antibodies}}, language = {{eng}}, number = {{6}}, pages = {{337--343}}, publisher = {{Springer}}, series = {{Blut}}, title = {{Demonstration of antibodies binding to autologous and allogeneic leukemic cells in childhood ALL - Evidence for a common ALL antigen(s)}}, url = {{http://dx.doi.org/10.1007/BF00320780}}, doi = {{10.1007/BF00320780}}, volume = {{52}}, year = {{1986}}, }