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Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

van Der Plas, Mariena LU ; Bhongir, Ravi LU orcid ; Kjellström, Sven LU ; Siller, Helena ; Kasetty, Gopinath LU ; Mörgelin, Matthias LU and Schmidtchen, Artur LU (2016) In Nature Communications 7.
Abstract

Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns in vitro and in vivo by preventing toll-like receptor dimerization and subsequent activation of down-stream signalling pathways. Thus, P. aeruginosa 'hijacks' an endogenous anti-inflammatory peptide-based mechanism, thereby enabling modulation and circumvention of host responses.

Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inflammatory responses, Pseudomonas aeruginosa
in
Nature Communications
volume
7
article number
11567
pages
13 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:84968883567
  • pmid:27181065
  • wos:000375938800001
ISSN
2041-1723
DOI
10.1038/ncomms11567
project
Host-pathogen interactions and the development of chronic infections
language
English
LU publication?
yes
id
f126110c-7c6e-44ef-a75d-4fbf58f0d71d
date added to LUP
2016-06-16 08:53:45
date last changed
2024-04-05 02:02:54
@article{f126110c-7c6e-44ef-a75d-4fbf58f0d71d,
  abstract     = {{<p>Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns in vitro and in vivo by preventing toll-like receptor dimerization and subsequent activation of down-stream signalling pathways. Thus, P. aeruginosa 'hijacks' an endogenous anti-inflammatory peptide-based mechanism, thereby enabling modulation and circumvention of host responses.</p>}},
  author       = {{van Der Plas, Mariena and Bhongir, Ravi and Kjellström, Sven and Siller, Helena and Kasetty, Gopinath and Mörgelin, Matthias and Schmidtchen, Artur}},
  issn         = {{2041-1723}},
  keywords     = {{inflammatory responses; Pseudomonas aeruginosa}},
  language     = {{eng}},
  month        = {{05}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{<i>Pseudomonas aeruginosa</i> elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses}},
  url          = {{http://dx.doi.org/10.1038/ncomms11567}},
  doi          = {{10.1038/ncomms11567}},
  volume       = {{7}},
  year         = {{2016}},
}