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Carpal Tunnel Syndrome and Diabetes—A Comprehensive Review

Zimmerman, Malin LU orcid ; Gottsäter, Anders LU and Dahlin, Lars B. LU orcid (2022) In Journal of Clinical Medicine 11(6).
Abstract

Carpal tunnel syndrome (CTS) is the most common compression neuropathy in the general population and is frequently encountered among individuals with type 1 and 2 diabetes. The reason(s) why a peripheral nerve trunk in individuals with diabetes is more susceptible to nerve compression is still not completely clarified, but both biochemical and structural changes in the peripheral nerve are probably implicated. In particular, individuals with neuropathy, irrespective of aetiology, have a higher risk of peripheral nerve compression disorders, as reflected among individuals with diabetic neuropathy. Diagnosis of CTS in individuals with diabetes should be carefully evaluated; detailed case history, thorough clinical examination, and... (More)

Carpal tunnel syndrome (CTS) is the most common compression neuropathy in the general population and is frequently encountered among individuals with type 1 and 2 diabetes. The reason(s) why a peripheral nerve trunk in individuals with diabetes is more susceptible to nerve compression is still not completely clarified, but both biochemical and structural changes in the peripheral nerve are probably implicated. In particular, individuals with neuropathy, irrespective of aetiology, have a higher risk of peripheral nerve compression disorders, as reflected among individuals with diabetic neuropathy. Diagnosis of CTS in individuals with diabetes should be carefully evaluated; detailed case history, thorough clinical examination, and electrophysiological examination is recommended. Individuals with diabetes and CTS benefit from surgery to the same extent as otherwise healthy individuals with CTS. In the present review, we describe pathophysiological aspects of the nerve compression disorder CTS in relation to diabetes, current data contributing to the explanation of the increased risk for CTS in individuals with diabetes, as well as diagnostic methods, treatment options, and prognosis of CTS in diabetes.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Carpal tunnel syndrome, Diabetes, Diabetic neuropathy
in
Journal of Clinical Medicine
volume
11
issue
6
article number
1674
publisher
MDPI AG
external identifiers
  • pmid:35329999
  • scopus:85126593130
ISSN
2077-0383
DOI
10.3390/jcm11061674
language
English
LU publication?
yes
id
f13a35e3-8c85-45f0-bc38-b6d0521bea00
date added to LUP
2022-05-03 16:51:50
date last changed
2025-03-07 14:26:58
@article{f13a35e3-8c85-45f0-bc38-b6d0521bea00,
  abstract     = {{<p>Carpal tunnel syndrome (CTS) is the most common compression neuropathy in the general population and is frequently encountered among individuals with type 1 and 2 diabetes. The reason(s) why a peripheral nerve trunk in individuals with diabetes is more susceptible to nerve compression is still not completely clarified, but both biochemical and structural changes in the peripheral nerve are probably implicated. In particular, individuals with neuropathy, irrespective of aetiology, have a higher risk of peripheral nerve compression disorders, as reflected among individuals with diabetic neuropathy. Diagnosis of CTS in individuals with diabetes should be carefully evaluated; detailed case history, thorough clinical examination, and electrophysiological examination is recommended. Individuals with diabetes and CTS benefit from surgery to the same extent as otherwise healthy individuals with CTS. In the present review, we describe pathophysiological aspects of the nerve compression disorder CTS in relation to diabetes, current data contributing to the explanation of the increased risk for CTS in individuals with diabetes, as well as diagnostic methods, treatment options, and prognosis of CTS in diabetes.</p>}},
  author       = {{Zimmerman, Malin and Gottsäter, Anders and Dahlin, Lars B.}},
  issn         = {{2077-0383}},
  keywords     = {{Carpal tunnel syndrome; Diabetes; Diabetic neuropathy}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{6}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{Carpal Tunnel Syndrome and Diabetes—A Comprehensive Review}},
  url          = {{http://dx.doi.org/10.3390/jcm11061674}},
  doi          = {{10.3390/jcm11061674}},
  volume       = {{11}},
  year         = {{2022}},
}