Right ventricular longitudinal function is linked to left ventricular filling pressure in patients with repaired tetralogy of fallot
(2023) In International Journal of Cardiovascular Imaging 39(2). p.401-409- Abstract (Swedish)
- Experimental data on pulmonary regurgitation has linked right ventricular longitudinal function to left ventricular filling pressure in animals with induced and treated pulmonary regurgitation but this relationship has not been investigated in patients with repaired Tetralogy of Fallot (rToF). The aim of this study was to determine if right ventricular longitudinal function assessed using cardiovascular magnetic resonance (CMR) is associated with left ventricular filling pressure in patients with rToF. A second objective of this study was to determine if direction of septal movement is related to right ventricular pressure load in rToF. Eighteen patients with rToF undergoing CMR and heart catheterization prior to pulmonary valve... (More)
- Experimental data on pulmonary regurgitation has linked right ventricular longitudinal function to left ventricular filling pressure in animals with induced and treated pulmonary regurgitation but this relationship has not been investigated in patients with repaired Tetralogy of Fallot (rToF). The aim of this study was to determine if right ventricular longitudinal function assessed using cardiovascular magnetic resonance (CMR) is associated with left ventricular filling pressure in patients with rToF. A second objective of this study was to determine if direction of septal movement is related to right ventricular pressure load in rToF. Eighteen patients with rToF undergoing CMR and heart catheterization prior to pulmonary valve replacement were retrospectively included and catheter-based pressure measurements were compared with CMR-derived RV regional function. Left ventricular filling pressure was measured as precapillary wedge pressure (PCWP). Longitudinal contribution to RV stroke volume correlated with PCWP (r = 0.48; p = 0.046) but not with RV EF or pulmonary regurgitation. Neither RV longitudinal strain nor TAPSE showed correlation with PCWP. Longitudinal contribution to stroke volume was lower for the RV compared to the LV (49 vs 54%; p = 0.039). Direction of septal movement did not show a correlation with RV end-systolic pressure. Right ventricular longitudinal pumping is associated with left ventricular filling pressure in rToF-patients and this inter-ventricular coupling may explain LV underfilling in patients with pulmonary regurgitation and rToF and may be of value to determine right ventricular dysfunction. RV systolic pressure, however, cannot be assessed from the direction of septal movement, in these patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/f187ac31-ac5a-439c-9be1-7ee772e14f05
- author
- Johansson, Martin LU ; Binka, Edem ; Barnes, Benjamin ; Gaur, Lasya ; Hedström, Erik LU ; Kutty, Shelby and Carlsson, Marcus LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Cardiovascular Imaging
- volume
- 39
- issue
- 2
- pages
- 401 - 409
- publisher
- Springer
- external identifiers
-
- pmid:36115891
- scopus:85146237126
- ISSN
- 1875-8312
- DOI
- 10.1007/s10554-022-02728-3
- language
- Swedish
- LU publication?
- yes
- id
- f187ac31-ac5a-439c-9be1-7ee772e14f05
- date added to LUP
- 2022-10-18 16:10:39
- date last changed
- 2023-09-15 14:31:53
@article{f187ac31-ac5a-439c-9be1-7ee772e14f05, abstract = {{Experimental data on pulmonary regurgitation has linked right ventricular longitudinal function to left ventricular filling pressure in animals with induced and treated pulmonary regurgitation but this relationship has not been investigated in patients with repaired Tetralogy of Fallot (rToF). The aim of this study was to determine if right ventricular longitudinal function assessed using cardiovascular magnetic resonance (CMR) is associated with left ventricular filling pressure in patients with rToF. A second objective of this study was to determine if direction of septal movement is related to right ventricular pressure load in rToF. Eighteen patients with rToF undergoing CMR and heart catheterization prior to pulmonary valve replacement were retrospectively included and catheter-based pressure measurements were compared with CMR-derived RV regional function. Left ventricular filling pressure was measured as precapillary wedge pressure (PCWP). Longitudinal contribution to RV stroke volume correlated with PCWP (r = 0.48; p = 0.046) but not with RV EF or pulmonary regurgitation. Neither RV longitudinal strain nor TAPSE showed correlation with PCWP. Longitudinal contribution to stroke volume was lower for the RV compared to the LV (49 vs 54%; p = 0.039). Direction of septal movement did not show a correlation with RV end-systolic pressure. Right ventricular longitudinal pumping is associated with left ventricular filling pressure in rToF-patients and this inter-ventricular coupling may explain LV underfilling in patients with pulmonary regurgitation and rToF and may be of value to determine right ventricular dysfunction. RV systolic pressure, however, cannot be assessed from the direction of septal movement, in these patients.}}, author = {{Johansson, Martin and Binka, Edem and Barnes, Benjamin and Gaur, Lasya and Hedström, Erik and Kutty, Shelby and Carlsson, Marcus}}, issn = {{1875-8312}}, language = {{swe}}, number = {{2}}, pages = {{401--409}}, publisher = {{Springer}}, series = {{International Journal of Cardiovascular Imaging}}, title = {{Right ventricular longitudinal function is linked to left ventricular filling pressure in patients with repaired tetralogy of fallot}}, url = {{http://dx.doi.org/10.1007/s10554-022-02728-3}}, doi = {{10.1007/s10554-022-02728-3}}, volume = {{39}}, year = {{2023}}, }