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Pancreatic cancer is suppressed by fibroblast-derived collagen I

Madsen, Chris LU (2021) In Cancer Cell 39(4). p.451-453
Abstract
Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune
suppression and accelerates progression of disease.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Cell
volume
39
issue
4
pages
3 pages
publisher
Cell Press
external identifiers
  • scopus:85103736753
  • pmid:33711271
ISSN
1878-3686
DOI
10.1016/j.ccell.2021.02.017
language
English
LU publication?
yes
id
f29545d8-406b-445d-b4e7-299d83297182
date added to LUP
2021-03-11 16:55:50
date last changed
2025-10-14 11:48:23
@article{f29545d8-406b-445d-b4e7-299d83297182,
  abstract     = {{Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune<br/>suppression and accelerates progression of disease.}},
  author       = {{Madsen, Chris}},
  issn         = {{1878-3686}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  pages        = {{451--453}},
  publisher    = {{Cell Press}},
  series       = {{Cancer Cell}},
  title        = {{Pancreatic cancer is suppressed by fibroblast-derived collagen I}},
  url          = {{http://dx.doi.org/10.1016/j.ccell.2021.02.017}},
  doi          = {{10.1016/j.ccell.2021.02.017}},
  volume       = {{39}},
  year         = {{2021}},
}