Pancreatic cancer is suppressed by fibroblast-derived collagen I
(2021) In Cancer Cell 39(4). p.451-453- Abstract
- Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune
suppression and accelerates progression of disease.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/f29545d8-406b-445d-b4e7-299d83297182
- author
- Madsen, Chris LU
- organization
- publishing date
- 2021-04-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Cell
- volume
- 39
- issue
- 4
- pages
- 3 pages
- publisher
- Cell Press
- external identifiers
-
- scopus:85103736753
- pmid:33711271
- ISSN
- 1878-3686
- DOI
- 10.1016/j.ccell.2021.02.017
- language
- English
- LU publication?
- yes
- id
- f29545d8-406b-445d-b4e7-299d83297182
- date added to LUP
- 2021-03-11 16:55:50
- date last changed
- 2022-04-27 00:43:22
@article{f29545d8-406b-445d-b4e7-299d83297182, abstract = {{Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune<br/>suppression and accelerates progression of disease.}}, author = {{Madsen, Chris}}, issn = {{1878-3686}}, language = {{eng}}, month = {{04}}, number = {{4}}, pages = {{451--453}}, publisher = {{Cell Press}}, series = {{Cancer Cell}}, title = {{Pancreatic cancer is suppressed by fibroblast-derived collagen I}}, url = {{http://dx.doi.org/10.1016/j.ccell.2021.02.017}}, doi = {{10.1016/j.ccell.2021.02.017}}, volume = {{39}}, year = {{2021}}, }