Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Excess Body Fatness during Early to Mid-Adulthood and Survival from Colorectal and Breast Cancer : A Pooled Analysis of Five International Cohort Studies

Charvat, Hadrien ; Freisling, Heinz ; Noh, Hwayoung ; Gaudet, Mia M. ; Gunter, Marc J. ; Cross, Amanda J. ; Tsilidis, Konstantinos K. ; Tjønneland, Anne ; Katzke, Verena and Bergmann, Manuela , et al. (2022) In Cancer Epidemiology Biomarkers and Prevention 31(2). p.325-333
Abstract

Background: Here, we explore the association between excess weight during early to mid-adulthood and survival in patients diagnosed with breast and colorectal cancer, using a pooled analysis of five cohort studies and study participants from 11 countries. Methods: Participant-level body mass index (BMI) trajectories were estimated by fitting a growth curve model using over 2 million repeated BMI measurements from close to 600,000 cohort participants. Cumulative measures of excess weight were derived. Data from over 23,000 patients with breast and colorectal cancer were subsequently analyzed using time-to-event models for death with the date of diagnosis as start of follow-up. Study-specific results were combined through a random effect... (More)

Background: Here, we explore the association between excess weight during early to mid-adulthood and survival in patients diagnosed with breast and colorectal cancer, using a pooled analysis of five cohort studies and study participants from 11 countries. Methods: Participant-level body mass index (BMI) trajectories were estimated by fitting a growth curve model using over 2 million repeated BMI measurements from close to 600,000 cohort participants. Cumulative measures of excess weight were derived. Data from over 23,000 patients with breast and colorectal cancer were subsequently analyzed using time-to-event models for death with the date of diagnosis as start of follow-up. Study-specific results were combined through a random effect meta-analysis. Results: We found a significant dose–response relationship (P trend ¼ 0.013) between the average BMI during early and mid-adulthood and death from breast cancer, with a pooled HR of 1.31 (1.07–1.60) and the time to death shortened by 16% for average BMI above 25 kg/m2 compared with average BMI less than or equal to 22.5 kg/m2, respectively. Similar results were found for categories of cumulative time spent with excess weight. There was no association between excess body fatness during early to mid-adulthood and death in patients with colorectal cancer. Conclusions: Excess body fatness during early to mid-adulthood is associated not only with an increased risk of developing cancer, but also with a lower survival in patients with breast cancer.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Epidemiology Biomarkers and Prevention
volume
31
issue
2
pages
9 pages
publisher
American Association for Cancer Research
external identifiers
  • scopus:85124180072
  • pmid:34782393
ISSN
1055-9965
DOI
10.1158/1055-9965.EPI-21-0688
language
English
LU publication?
yes
additional info
Funding Information: The authors would like to thank all study participants and study staff for their valuable contribution to this research. The authors also would like to thank the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, for their contribution and ongoing support to the EPIC Study. This study was funded by the World Cancer Research Fund International (grant number 2016/1636, to I. Soerjomataram). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark), Ligue Contre le Cancer; Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, and Institut National de la Santé et de la Recherche Médicale (INSERM, France); German Cancer Aid, German Cancer Research Center (DKFZ), and Federal Ministry of Education and Research (BMBF, Germany); Italian Association for Research on Cancer (AIRC), National Research Council, and Associazione Iblea per la Ricerca Epidemiologica (AIRE-ONLUS) Ragusa, Associazione Volontari Italiani Sangu (AVIS) Ragusa, and Sicilian Government (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (the Netherlands); Health Research Fund (FIS), Regional Governments of Andalucía, Asturias, Basque Country, Murcia (No. 6236) and Navarra, and the Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública and Instituto de Salud Carlos II (ISCIII RETIC; RD06/0020, Spain); Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology (ICO, Spain); Swedish Cancer Society, Swedish Scientific Council, and Regional Government of Skå ne and V€asterbotten (Sweden); and Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 and C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford; United Kingdom), Stroke Association, British Heart Foundation, Department of Health, Food Standards Agency, and the Wellcome Trust (UK). The EPIC-Norfolk study (DOI 10.22025/ 2019.10.105.00004) has received funding from the Medical Research Council (MR/ N003284/1 and MC-UU_12015/1) and Cancer Research UK (C864/A14136). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the article. Funding Information: This study was funded by the World Cancer Research Fund International (grant number 2016/1636, to I. Soerjomataram). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark), Ligue Contre le Cancer; Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, and Institut National de la Santéet de la Recherche Médicale (INSERM, France); German Cancer Aid, German Cancer Research Center (DKFZ), and Federal Ministry of Education and Research (BMBF, Germany); Italian Association for Research on Cancer (AIRC), National Research Council, and Associazione Iblea per la Ricerca Epidemiologica (AIRE-ONLUS) Ragusa, Associazione Volontari Italiani Sangu (AVIS) Ragusa, and Sicilian Government (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (the Netherlands); Health Research Fund (FIS), Regional Governments of Andalucía, Asturias, Basque Country, Murcia (No. 6236) and Navarra, and the Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública and Instituto de Salud Carlos II (ISCIII RETIC; RD06/0020, Spain); Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Funding Information: H. Charvat reports grants from World Cancer Research Fund International (grant number 2016/1636) during the conduct of the study. H. Freisling, I. Soerjomataram, and M. Arnold report grants from World Cancer Research Fund International during the conduct of the study. N. Sawada reports grants from National Cancer Center Research and Development Fund during the conduct of the study. No disclosures were reported by the other authors. Publisher Copyright: ©2021 American Association for Cancer Research
id
f2b55754-bacd-4284-90ad-7a08368163d0
date added to LUP
2022-12-30 13:34:39
date last changed
2024-04-14 23:58:49
@article{f2b55754-bacd-4284-90ad-7a08368163d0,
  abstract     = {{<p>Background: Here, we explore the association between excess weight during early to mid-adulthood and survival in patients diagnosed with breast and colorectal cancer, using a pooled analysis of five cohort studies and study participants from 11 countries. Methods: Participant-level body mass index (BMI) trajectories were estimated by fitting a growth curve model using over 2 million repeated BMI measurements from close to 600,000 cohort participants. Cumulative measures of excess weight were derived. Data from over 23,000 patients with breast and colorectal cancer were subsequently analyzed using time-to-event models for death with the date of diagnosis as start of follow-up. Study-specific results were combined through a random effect meta-analysis. Results: We found a significant dose–response relationship (P trend ¼ 0.013) between the average BMI during early and mid-adulthood and death from breast cancer, with a pooled HR of 1.31 (1.07–1.60) and the time to death shortened by 16% for average BMI above 25 kg/m<sup>2</sup> compared with average BMI less than or equal to 22.5 kg/m<sup>2</sup>, respectively. Similar results were found for categories of cumulative time spent with excess weight. There was no association between excess body fatness during early to mid-adulthood and death in patients with colorectal cancer. Conclusions: Excess body fatness during early to mid-adulthood is associated not only with an increased risk of developing cancer, but also with a lower survival in patients with breast cancer.</p>}},
  author       = {{Charvat, Hadrien and Freisling, Heinz and Noh, Hwayoung and Gaudet, Mia M. and Gunter, Marc J. and Cross, Amanda J. and Tsilidis, Konstantinos K. and Tjønneland, Anne and Katzke, Verena and Bergmann, Manuela and Agnoli, Claudia and Rylander, Charlotta and Skeie, Guri and Jakszyn, Paula and Rosendahl, Ann H. and Sund, Malin and Severi, Gianluca and Tsugane, Shoichiro and Sawada, Norie and Brenner, Hermann and Adami, Hans Olov and Weiderpass, Elisabete and Soerjomataram, Isabelle and Arnold, Melina}},
  issn         = {{1055-9965}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{325--333}},
  publisher    = {{American Association for Cancer Research}},
  series       = {{Cancer Epidemiology Biomarkers and Prevention}},
  title        = {{Excess Body Fatness during Early to Mid-Adulthood and Survival from Colorectal and Breast Cancer : A Pooled Analysis of Five International Cohort Studies}},
  url          = {{http://dx.doi.org/10.1158/1055-9965.EPI-21-0688}},
  doi          = {{10.1158/1055-9965.EPI-21-0688}},
  volume       = {{31}},
  year         = {{2022}},
}