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CD8αβ+ γδ T cells : A novel T cell subset with a potential role in inflammatory bowel disease

Kadivar, Mohammad LU ; Petersson, Julia; Svensson, Lena LU and Marsal, Jan LU (2016) In Journal of Immunology 197(12). p.4584-4592
Abstract

γδ T cells have been attributed a wide variety of functions, which in some cases may appear as contradictory. To better understand the enigmatic biology of γδ T cells it is crucial to define the constituting subpopulations. γδ T cells have previously been categorized into two subpopulations: CD8aa+ and CD8- cells. In this study we have defined and characterized a novel subset of human γδ T-cells expressing CD8ab. These CD8αβ+ γδ T cells differed from the previously described γδ T cell subsets in several aspects, including the degree of enrichment within the gut mucosa, the activation status in blood, the type of TCRd variant used in blood, and small but significant differences in their response to IL-2 stimulation.... (More)

γδ T cells have been attributed a wide variety of functions, which in some cases may appear as contradictory. To better understand the enigmatic biology of γδ T cells it is crucial to define the constituting subpopulations. γδ T cells have previously been categorized into two subpopulations: CD8aa+ and CD8- cells. In this study we have defined and characterized a novel subset of human γδ T-cells expressing CD8ab. These CD8αβ+ γδ T cells differed from the previously described γδ T cell subsets in several aspects, including the degree of enrichment within the gut mucosa, the activation status in blood, the type of TCRd variant used in blood, and small but significant differences in their response to IL-2 stimulation. Furthermore, the novel subset expressed cytotoxic mediators and CD69, and produced IFN-γ and TNF-α. In patients with active inflammatory bowel disease the mucosal frequencies of CD8αβ+ γδ T cells were significantly lower as compared with healthy controls, correlated negatively with the degree of disease activity, and increased to normal levels as a result of anti-TNF-a therapy. In conclusion, our results demonstrate that CD8αβ+ γδ T cells constitute a novel lymphocyte subset, which is strongly enriched within the gut and may play an important role in gut homeostasis and mucosal healing in inflammatory bowel disease.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Immunology
volume
197
issue
12
pages
9 pages
publisher
American Association of Immunologists
external identifiers
  • scopus:85002374635
  • wos:000389635900010
ISSN
0022-1767
DOI
10.4049/jimmunol.1601146
language
English
LU publication?
yes
id
f33efc8c-d890-43ed-90c3-1de21f238b52
date added to LUP
2016-12-23 07:38:16
date last changed
2017-11-05 05:11:32
@article{f33efc8c-d890-43ed-90c3-1de21f238b52,
  abstract     = {<p>γδ T cells have been attributed a wide variety of functions, which in some cases may appear as contradictory. To better understand the enigmatic biology of γδ T cells it is crucial to define the constituting subpopulations. γδ T cells have previously been categorized into two subpopulations: CD8aa+ and CD8<sup>-</sup> cells. In this study we have defined and characterized a novel subset of human γδ T-cells expressing CD8ab. These CD8αβ<sup>+</sup> γδ T cells differed from the previously described γδ T cell subsets in several aspects, including the degree of enrichment within the gut mucosa, the activation status in blood, the type of TCRd variant used in blood, and small but significant differences in their response to IL-2 stimulation. Furthermore, the novel subset expressed cytotoxic mediators and CD69, and produced IFN-γ and TNF-α. In patients with active inflammatory bowel disease the mucosal frequencies of CD8αβ<sup>+</sup> γδ T cells were significantly lower as compared with healthy controls, correlated negatively with the degree of disease activity, and increased to normal levels as a result of anti-TNF-a therapy. In conclusion, our results demonstrate that CD8αβ<sup>+</sup> γδ T cells constitute a novel lymphocyte subset, which is strongly enriched within the gut and may play an important role in gut homeostasis and mucosal healing in inflammatory bowel disease.</p>},
  author       = {Kadivar, Mohammad and Petersson, Julia and Svensson, Lena and Marsal, Jan},
  issn         = {0022-1767},
  language     = {eng},
  month        = {12},
  number       = {12},
  pages        = {4584--4592},
  publisher    = {American Association of Immunologists},
  series       = {Journal of Immunology},
  title        = {CD8αβ<sup>+</sup> γδ T cells : A novel T cell subset with a potential role in inflammatory bowel disease},
  url          = {http://dx.doi.org/10.4049/jimmunol.1601146},
  volume       = {197},
  year         = {2016},
}