Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Nutritional status and outcome of surgery : A prospective observational cohort study of children at a tertiary surgical hospital in Harare, Zimbabwe

Bergkvist, Emil ; Zimunhu, Taurai ; Mbanje, Chenesa ; Hagander, Lars LU orcid and Muguti, G. I. (2021) In Journal of Pediatric Surgery 56(2). p.368-373
Abstract

Background: Undernutrition contributes to nearly 50% of all child deaths in the world, yet there is conflicting evidence regarding the association between nutritional status and postoperative complications. The aim was to describe the preoperative nutritional status among pediatric surgery patients in Zimbabwe, and to assess if nutritional status was a risk factor for adverse postoperative outcome of mortality, surgical site infection, reoperation, readmission, and longer length of stay. Methods: This prospective observational cohort study included 136 children undergoing surgery at a tertiary pediatric hospital in Zimbabwe. Nutritional status was standardized using Z-scores for BMI, length, weight, and middle upper arm circumference.... (More)

Background: Undernutrition contributes to nearly 50% of all child deaths in the world, yet there is conflicting evidence regarding the association between nutritional status and postoperative complications. The aim was to describe the preoperative nutritional status among pediatric surgery patients in Zimbabwe, and to assess if nutritional status was a risk factor for adverse postoperative outcome of mortality, surgical site infection, reoperation, readmission, and longer length of stay. Methods: This prospective observational cohort study included 136 children undergoing surgery at a tertiary pediatric hospital in Zimbabwe. Nutritional status was standardized using Z-scores for BMI, length, weight, and middle upper arm circumference. Primary outcomes after 30 days included mortality, surgical site infection, reoperation, and readmission. Secondary outcome was length of stay. Univariate and multivariable analyses with logistic regression were performed. Results: Of the 136 patients, 31% were undernourished. Postoperative adverse outcome occurred in 20%; the mortality rate was 6%, the surgical site infection rate was 17%, the reoperation rate was 3.5%, and readmission rate was 2.5%. Nutritional status, higher ASA classification, major surgical procedures, and lower preoperative hemoglobin levels were associated with adverse outcome. Univariate logistic regression identified a seven-fold increased risk of postoperative complications among undernourished children (OR 7.3 [2.3–22.8], p = 0.001), and there was a four- to six-fold increased adjusted risk after adjustment for ASA, major surgery, and preoperative hemoglobin. Conclusion: A third of all pediatric surgery patients were undernourished, and undernourished children had a considerably higher risk of adverse outcome. With a positive correlation identified between undernourishment and increased postoperative complications, future aims would include assessing if preoperative nutritional treatment could be especially beneficial for undernourished children. Levels of Evidence: Level II treatment study.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Nutritional status, Pediatric surgery, Perioperative mortality, Postoperative complications, Zimbabwe
in
Journal of Pediatric Surgery
volume
56
issue
2
pages
368 - 373
publisher
Elsevier
external identifiers
  • pmid:33131772
  • scopus:85094813453
ISSN
0022-3468
DOI
10.1016/j.jpedsurg.2020.09.020
language
English
LU publication?
yes
id
f34959b1-8fd5-4343-9453-410104f09fb1
date added to LUP
2020-11-23 06:59:39
date last changed
2024-06-27 01:49:46
@article{f34959b1-8fd5-4343-9453-410104f09fb1,
  abstract     = {{<p>Background: Undernutrition contributes to nearly 50% of all child deaths in the world, yet there is conflicting evidence regarding the association between nutritional status and postoperative complications. The aim was to describe the preoperative nutritional status among pediatric surgery patients in Zimbabwe, and to assess if nutritional status was a risk factor for adverse postoperative outcome of mortality, surgical site infection, reoperation, readmission, and longer length of stay. Methods: This prospective observational cohort study included 136 children undergoing surgery at a tertiary pediatric hospital in Zimbabwe. Nutritional status was standardized using Z-scores for BMI, length, weight, and middle upper arm circumference. Primary outcomes after 30 days included mortality, surgical site infection, reoperation, and readmission. Secondary outcome was length of stay. Univariate and multivariable analyses with logistic regression were performed. Results: Of the 136 patients, 31% were undernourished. Postoperative adverse outcome occurred in 20%; the mortality rate was 6%, the surgical site infection rate was 17%, the reoperation rate was 3.5%, and readmission rate was 2.5%. Nutritional status, higher ASA classification, major surgical procedures, and lower preoperative hemoglobin levels were associated with adverse outcome. Univariate logistic regression identified a seven-fold increased risk of postoperative complications among undernourished children (OR 7.3 [2.3–22.8], p = 0.001), and there was a four- to six-fold increased adjusted risk after adjustment for ASA, major surgery, and preoperative hemoglobin. Conclusion: A third of all pediatric surgery patients were undernourished, and undernourished children had a considerably higher risk of adverse outcome. With a positive correlation identified between undernourishment and increased postoperative complications, future aims would include assessing if preoperative nutritional treatment could be especially beneficial for undernourished children. Levels of Evidence: Level II treatment study.</p>}},
  author       = {{Bergkvist, Emil and Zimunhu, Taurai and Mbanje, Chenesa and Hagander, Lars and Muguti, G. I.}},
  issn         = {{0022-3468}},
  keywords     = {{Nutritional status; Pediatric surgery; Perioperative mortality; Postoperative complications; Zimbabwe}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{368--373}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Pediatric Surgery}},
  title        = {{Nutritional status and outcome of surgery : A prospective observational cohort study of children at a tertiary surgical hospital in Harare, Zimbabwe}},
  url          = {{http://dx.doi.org/10.1016/j.jpedsurg.2020.09.020}},
  doi          = {{10.1016/j.jpedsurg.2020.09.020}},
  volume       = {{56}},
  year         = {{2021}},
}