Epidemiological register studies on pain - etiology, treatment, and mental health
(2023) In Lund University, Faculty of Medicine Doctoral Dissertation Series- Abstract
- Pain is common in life and can be caused by trauma or underlying disease and is mostly temporary, but for some the
pain can develop into a chronic pain condition. Pain leads to individual suffering as well as negative impact on the
wider society. Especially since pain can start early in life and affect large parts of it.
The aim of this thesis was to identify potential risk factors for chronic and widespread pain, and to study associated
comorbidities and prescription drug use. This was done by using the extensive electronic health records and registers
available in Sweden to perform four population-based cohort studies.
Study I: We investigated the effect of rheumatoid arthritis, endometriosis, and... (More) - Pain is common in life and can be caused by trauma or underlying disease and is mostly temporary, but for some the
pain can develop into a chronic pain condition. Pain leads to individual suffering as well as negative impact on the
wider society. Especially since pain can start early in life and affect large parts of it.
The aim of this thesis was to identify potential risk factors for chronic and widespread pain, and to study associated
comorbidities and prescription drug use. This was done by using the extensive electronic health records and registers
available in Sweden to perform four population-based cohort studies.
Study I: We investigated the effect of rheumatoid arthritis, endometriosis, and inflammatory bowel disease, three
diseases with recurrent pain as a common feature, on the risk of developing chronic pain. We showed that all three
diseases were risk factors for widespread pain.
Study II: We investigated the temporal relationship between pain and mental illness and found a bidirectional
relationship where the two conditions increase the risk for each other.
Study III: We investigated risk factors for prolonged opioid use after distal radius fracture. We found that previous
opioid use, mental illness, and surgery acted as risk factors whereas occupational/physical therapy decreased the
risk.
Study IV: We studied trends in yearly prevalence of diagnoses for pain and mental health conditions and associated
prescription drug use in adolescents and young adults. We found decreasing prevalence of pain diagnoses but a
steep increase in mental health conditions and associated prescription drugs.
Our results propose early identification and treatment for chronic diseases where recurrent pain is a common
symptom to decrease the risk of chronic pain. Moreover, since pain and mental illness act as risk factors for each
other monitoring both conditions among individuals affected by either could be beneficial to improve patient wellbeing.
This is especially important since our studies also show that both pain and mental illness and associated prescription
drugs are common in young people. Finally, screening for previous regular opioid use could be considered when
initiating treatment for distal radius fracture. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/f3846852-e7de-4e94-8e7c-1efe768ea108
- author
- Larrosa Pardo, Fabian LU
- supervisor
- opponent
-
- Associate Professor Mansfield, Kathryn, London School of Hygiene and Tropical Medicine, Faculty of Epidemiology and population Health, Department of Non-Communicable Disease Epidemiology
- organization
- publishing date
- 2023
- type
- Thesis
- publication status
- published
- subject
- keywords
- smärta, Registerstudier, Epidemiologi, Pain, Epidemiology, register studies
- in
- Lund University, Faculty of Medicine Doctoral Dissertation Series
- issue
- 2023:94
- pages
- 74 pages
- publisher
- Lund University, Faculty of Medicine
- defense location
- Belfragesalen, BMC D15, Klinikgatan 32 i Lund. Zoom: https://lu-se.zoom.us/j/62427077549
- defense date
- 2023-09-01 09:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-8021-434-6
- language
- English
- LU publication?
- yes
- id
- f3846852-e7de-4e94-8e7c-1efe768ea108
- date added to LUP
- 2023-08-11 09:07:29
- date last changed
- 2023-08-21 08:37:39
@phdthesis{f3846852-e7de-4e94-8e7c-1efe768ea108,
abstract = {{Pain is common in life and can be caused by trauma or underlying disease and is mostly temporary, but for some the <br/>pain can develop into a chronic pain condition. Pain leads to individual suffering as well as negative impact on the <br/>wider society. Especially since pain can start early in life and affect large parts of it. <br/>The aim of this thesis was to identify potential risk factors for chronic and widespread pain, and to study associated <br/>comorbidities and prescription drug use. This was done by using the extensive electronic health records and registers <br/>available in Sweden to perform four population-based cohort studies. <br/>Study I: We investigated the effect of rheumatoid arthritis, endometriosis, and inflammatory bowel disease, three <br/>diseases with recurrent pain as a common feature, on the risk of developing chronic pain. We showed that all three <br/>diseases were risk factors for widespread pain. <br/>Study II: We investigated the temporal relationship between pain and mental illness and found a bidirectional <br/>relationship where the two conditions increase the risk for each other. <br/>Study III: We investigated risk factors for prolonged opioid use after distal radius fracture. We found that previous <br/>opioid use, mental illness, and surgery acted as risk factors whereas occupational/physical therapy decreased the <br/>risk. <br/>Study IV: We studied trends in yearly prevalence of diagnoses for pain and mental health conditions and associated <br/>prescription drug use in adolescents and young adults. We found decreasing prevalence of pain diagnoses but a <br/>steep increase in mental health conditions and associated prescription drugs. <br/>Our results propose early identification and treatment for chronic diseases where recurrent pain is a common <br/>symptom to decrease the risk of chronic pain. Moreover, since pain and mental illness act as risk factors for each <br/>other monitoring both conditions among individuals affected by either could be beneficial to improve patient wellbeing. <br/>This is especially important since our studies also show that both pain and mental illness and associated prescription <br/>drugs are common in young people. Finally, screening for previous regular opioid use could be considered when <br/>initiating treatment for distal radius fracture.}},
author = {{Larrosa Pardo, Fabian}},
isbn = {{978-91-8021-434-6}},
issn = {{1652-8220}},
keywords = {{smärta; Registerstudier; Epidemiologi; Pain; Epidemiology; register studies}},
language = {{eng}},
number = {{2023:94}},
publisher = {{Lund University, Faculty of Medicine}},
school = {{Lund University}},
series = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}},
title = {{Epidemiological register studies on pain - etiology, treatment, and mental health}},
url = {{https://lup.lub.lu.se/search/files/154584601/Fabian_Larrosa_Pardo_WEBB.pdf}},
year = {{2023}},
}