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Multiple Anticancer Effects of Damsin and Coronopilin Isolated from Ambrosia arborescens on Cell Cultures.

Villagomez, Rodrigo LU ; Rodrigo, Gloria LU ; Collado, Isidro G ; Calzado, Marco A ; Muñoz, Eduardo ; Åkesson, Björn LU ; Sterner, Olov LU ; Almanza, Giovanna R and Duan, Rui-Dong LU (2013) In Anticancer research 33(9). p.3799-3805
Abstract
Terpenoids in plants are important sources for drug discovery. In this study, we extracted damsin and coronopilin, two sesquiterpene lactones, from Ambrosia arborescens and examined their anticancer effects on cell cultures. Damsin and coronopilin inhibited cell proliferation, DNA biosynthesis and formation of cytoplasmic DNA histone complexes in Caco-2 cells, with damsin being more potent than coronopilin. Further studies using the luciferase reporter system showed that damsin and coronopilin also inhibited expressions of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription-3 (STAT3), indicating that these sesquiterpenes can interfere with NF-κB and STAT3 pathways. Finally, we examined the effects of two... (More)
Terpenoids in plants are important sources for drug discovery. In this study, we extracted damsin and coronopilin, two sesquiterpene lactones, from Ambrosia arborescens and examined their anticancer effects on cell cultures. Damsin and coronopilin inhibited cell proliferation, DNA biosynthesis and formation of cytoplasmic DNA histone complexes in Caco-2 cells, with damsin being more potent than coronopilin. Further studies using the luciferase reporter system showed that damsin and coronopilin also inhibited expressions of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription-3 (STAT3), indicating that these sesquiterpenes can interfere with NF-κB and STAT3 pathways. Finally, we examined the effects of two synthetic dibrominated derivatives of damsin, 11α,13-dibromodamsin and 11β,13-dibromodamsin. While bromination appeared to weaken the antiproliferative effects of damsin, the β epimer had strong inhibitory effects on STAT3 activation. In conclusion, the sesquiterpene lactones damsin and coronopilin have inhibitory effects on cell proliferation, DNA biosynthesis and NF-κB and STAT3 pathways, thus being potentially important for discovery of drugs against cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anticancer research
volume
33
issue
9
pages
3799 - 3805
publisher
International Institute of Cancer Research
external identifiers
  • wos:000327055200035
  • pmid:24023312
  • scopus:84885004403
ISSN
1791-7530
language
English
LU publication?
yes
id
f3acf483-aff6-47e7-ad75-1959ef32a0a4 (old id 4066028)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24023312?dopt=Abstract
date added to LUP
2016-04-01 10:23:59
date last changed
2020-01-12 03:29:29
@article{f3acf483-aff6-47e7-ad75-1959ef32a0a4,
  abstract     = {Terpenoids in plants are important sources for drug discovery. In this study, we extracted damsin and coronopilin, two sesquiterpene lactones, from Ambrosia arborescens and examined their anticancer effects on cell cultures. Damsin and coronopilin inhibited cell proliferation, DNA biosynthesis and formation of cytoplasmic DNA histone complexes in Caco-2 cells, with damsin being more potent than coronopilin. Further studies using the luciferase reporter system showed that damsin and coronopilin also inhibited expressions of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription-3 (STAT3), indicating that these sesquiterpenes can interfere with NF-κB and STAT3 pathways. Finally, we examined the effects of two synthetic dibrominated derivatives of damsin, 11α,13-dibromodamsin and 11β,13-dibromodamsin. While bromination appeared to weaken the antiproliferative effects of damsin, the β epimer had strong inhibitory effects on STAT3 activation. In conclusion, the sesquiterpene lactones damsin and coronopilin have inhibitory effects on cell proliferation, DNA biosynthesis and NF-κB and STAT3 pathways, thus being potentially important for discovery of drugs against cancer.},
  author       = {Villagomez, Rodrigo and Rodrigo, Gloria and Collado, Isidro G and Calzado, Marco A and Muñoz, Eduardo and Åkesson, Björn and Sterner, Olov and Almanza, Giovanna R and Duan, Rui-Dong},
  issn         = {1791-7530},
  language     = {eng},
  number       = {9},
  pages        = {3799--3805},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer research},
  title        = {Multiple Anticancer Effects of Damsin and Coronopilin Isolated from Ambrosia arborescens on Cell Cultures.},
  url          = {http://www.ncbi.nlm.nih.gov/pubmed/24023312?dopt=Abstract},
  volume       = {33},
  year         = {2013},
}