The radiation dose to overweighted patients undergoing myocardial perfusion SPECT can be significantly reduced : validation of a linear weight-adjusted activity administration protocol
(2017) In Journal of Nuclear Cardiology 24(6). p.1912-1921- Abstract
Background: Large body size can cause a higher proportion of emitted photons being attenuated within the patient. Therefore, clinical myocardial perfusion SPECT (MPS) protocols often include unproportionally higher radioisotope activity to obese patients. The aim was to evaluate if a linear weight-adjusted low-dose protocol can be applied to obese patients and thereby decrease radiation exposure. Methods and result: Two hundred patients (>110 kg, BMI 18-41, [n = 69], ≤ 110 kg, BMI 31-58, [n = 131]) underwent 99mTc-tetrofosmin stress examination on a Cadmium Zinc Telluride or a conventional gamma camera using new generations of reconstruction algorithm (Resolution Recovery). Patients <110 kg were administered 2.5 MBq/kg,... (More)
Background: Large body size can cause a higher proportion of emitted photons being attenuated within the patient. Therefore, clinical myocardial perfusion SPECT (MPS) protocols often include unproportionally higher radioisotope activity to obese patients. The aim was to evaluate if a linear weight-adjusted low-dose protocol can be applied to obese patients and thereby decrease radiation exposure. Methods and result: Two hundred patients (>110 kg, BMI 18-41, [n = 69], ≤ 110 kg, BMI 31-58, [n = 131]) underwent 99mTc-tetrofosmin stress examination on a Cadmium Zinc Telluride or a conventional gamma camera using new generations of reconstruction algorithm (Resolution Recovery). Patients <110 kg were administered 2.5 MBq/kg, patients between 110 and 120 kg received 430 MBq and patients >120 kg received 570 MBq according to clinical routine. Patients >110 kg had 130% total number of counts in the images compared to patients <110 kg. Recalculating the counts to correspond to an administered activity of 2.5 MBq/kg resulted in similar number of counts across the groups. Image analyses in a subgroup with images corresponding to high activity and 2.5 MBq/kg showed no difference in image quality or ischemia quantification. Conclusion: Linear low-dose weight-adjusted protocol of 2.5 MBq/kg in MPS can be applied over a large weight span without loss of counts or image quality, resulting in a significant reduction in radiation exposure to obese patients.
(Less)
- author
- Oddstig, Jenny
LU
; Hindorf, Cecilia
LU
; Hedeer, Fredrik
LU
; Jögi, Jonas
LU
; Arheden, Håkan LU ; Hansson, Magnus LU
and Engblom, Henrik LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- conventional gamma camera, CZT detector, image quality, Myocardial perfusion imaging: SPECT, radiation dose
- in
- Journal of Nuclear Cardiology
- volume
- 24
- issue
- 6
- pages
- 1912 - 1921
- publisher
- Springer
- external identifiers
-
- pmid:27506700
- wos:000416345300018
- scopus:84981287297
- ISSN
- 1071-3581
- DOI
- 10.1007/s12350-016-0628-7
- language
- English
- LU publication?
- yes
- id
- f3f07ee5-35ff-4606-a7df-0808b1d2bba1
- date added to LUP
- 2016-09-20 13:59:50
- date last changed
- 2025-01-12 11:34:20
@article{f3f07ee5-35ff-4606-a7df-0808b1d2bba1, abstract = {{<p>Background: Large body size can cause a higher proportion of emitted photons being attenuated within the patient. Therefore, clinical myocardial perfusion SPECT (MPS) protocols often include unproportionally higher radioisotope activity to obese patients. The aim was to evaluate if a linear weight-adjusted low-dose protocol can be applied to obese patients and thereby decrease radiation exposure. Methods and result: Two hundred patients (>110 kg, BMI 18-41, [n = 69], ≤ 110 kg, BMI 31-58, [n = 131]) underwent <sup>99m</sup>Tc-tetrofosmin stress examination on a Cadmium Zinc Telluride or a conventional gamma camera using new generations of reconstruction algorithm (Resolution Recovery). Patients <110 kg were administered 2.5 MBq/kg, patients between 110 and 120 kg received 430 MBq and patients >120 kg received 570 MBq according to clinical routine. Patients >110 kg had 130% total number of counts in the images compared to patients <110 kg. Recalculating the counts to correspond to an administered activity of 2.5 MBq/kg resulted in similar number of counts across the groups. Image analyses in a subgroup with images corresponding to high activity and 2.5 MBq/kg showed no difference in image quality or ischemia quantification. Conclusion: Linear low-dose weight-adjusted protocol of 2.5 MBq/kg in MPS can be applied over a large weight span without loss of counts or image quality, resulting in a significant reduction in radiation exposure to obese patients.</p>}}, author = {{Oddstig, Jenny and Hindorf, Cecilia and Hedeer, Fredrik and Jögi, Jonas and Arheden, Håkan and Hansson, Magnus and Engblom, Henrik}}, issn = {{1071-3581}}, keywords = {{conventional gamma camera; CZT detector; image quality; Myocardial perfusion imaging: SPECT; radiation dose}}, language = {{eng}}, number = {{6}}, pages = {{1912--1921}}, publisher = {{Springer}}, series = {{Journal of Nuclear Cardiology}}, title = {{The radiation dose to overweighted patients undergoing myocardial perfusion SPECT can be significantly reduced : validation of a linear weight-adjusted activity administration protocol}}, url = {{http://dx.doi.org/10.1007/s12350-016-0628-7}}, doi = {{10.1007/s12350-016-0628-7}}, volume = {{24}}, year = {{2017}}, }