Relationship between cortical iron and tau aggregation in Alzheimer's disease
Spotorno, Nicola LU ; Acosta-Cabronero, Julio ; Stomrud, Erik LU
; Lampinen, Björn
LU
; Strandberg, Olof T.
LU
; van Westen, Danielle
LU
and Hansson, Oskar
LU
(2020)
In Brain : a journal of neurology
143(5).
p.1341-1349
- Abstract
A growing body of evidence suggests that the dysregulation of neuronal iron may play a critical role in Alzheimer's disease. Recent MRI studies have established a relationship between iron accumulation and amyloid-β aggregation. The present study provides further insight demonstrating a relationship between iron and tau accumulation using magnetic resonance-based quantitative susceptibility mapping and tau-PET in n = 236 subjects with amyloid-β pathology (from the Swedish BioFINDER-2 study). Both voxel-wise and regional analyses showed a consistent association between differences in bulk magnetic susceptibility, which can be primarily ascribed to an increase in iron content, and tau-PET signal in regions known to be affected in... (More)
A growing body of evidence suggests that the dysregulation of neuronal iron may play a critical role in Alzheimer's disease. Recent MRI studies have established a relationship between iron accumulation and amyloid-β aggregation. The present study provides further insight demonstrating a relationship between iron and tau accumulation using magnetic resonance-based quantitative susceptibility mapping and tau-PET in n = 236 subjects with amyloid-β pathology (from the Swedish BioFINDER-2 study). Both voxel-wise and regional analyses showed a consistent association between differences in bulk magnetic susceptibility, which can be primarily ascribed to an increase in iron content, and tau-PET signal in regions known to be affected in Alzheimer's disease. Subsequent analyses revealed that quantitative susceptibility specifically mediates the relationship between tau-PET and cortical atrophy measures, thus suggesting a modulatory effect of iron burden on the disease process. We also found evidence suggesting the relationship between quantitative susceptibility and tau-PET is stronger in younger participants (age ≤ 65). Together, these results provide in vivo evidence of an association between iron deposition and both tau aggregation and neurodegeneration, which help advance our understanding of the role of iron dysregulation in the Alzheimer's disease aetiology.
(Less)
- author
- Spotorno, Nicola
LU
; Acosta-Cabronero, Julio
; Stomrud, Erik
LU
; Lampinen, Björn
LU
; Strandberg, Olof T.
LU
; van Westen, Danielle
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2020-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer’s disease, iron, quantitative susceptibility mapping, tau, tau-PET
- in
- Brain : a journal of neurology
- volume
- 143
- issue
- 5
- pages
- 9 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:32330946
- scopus:85085155422
- ISSN
- 1460-2156
- DOI
- 10.1093/brain/awaa089
- language
- English
- LU publication?
- yes
- id
- f466b421-a7b4-471d-91e8-a1eaeeca8d5d
- date added to LUP
- 2020-06-17 09:52:29
- date last changed
- 2024-05-30 17:20:57
@article{f466b421-a7b4-471d-91e8-a1eaeeca8d5d,
abstract = {{<p>A growing body of evidence suggests that the dysregulation of neuronal iron may play a critical role in Alzheimer's disease. Recent MRI studies have established a relationship between iron accumulation and amyloid-β aggregation. The present study provides further insight demonstrating a relationship between iron and tau accumulation using magnetic resonance-based quantitative susceptibility mapping and tau-PET in n = 236 subjects with amyloid-β pathology (from the Swedish BioFINDER-2 study). Both voxel-wise and regional analyses showed a consistent association between differences in bulk magnetic susceptibility, which can be primarily ascribed to an increase in iron content, and tau-PET signal in regions known to be affected in Alzheimer's disease. Subsequent analyses revealed that quantitative susceptibility specifically mediates the relationship between tau-PET and cortical atrophy measures, thus suggesting a modulatory effect of iron burden on the disease process. We also found evidence suggesting the relationship between quantitative susceptibility and tau-PET is stronger in younger participants (age ≤ 65). Together, these results provide in vivo evidence of an association between iron deposition and both tau aggregation and neurodegeneration, which help advance our understanding of the role of iron dysregulation in the Alzheimer's disease aetiology.</p>}},
author = {{Spotorno, Nicola and Acosta-Cabronero, Julio and Stomrud, Erik and Lampinen, Björn and Strandberg, Olof T. and van Westen, Danielle and Hansson, Oskar}},
issn = {{1460-2156}},
keywords = {{Alzheimer’s disease; iron; quantitative susceptibility mapping; tau; tau-PET}},
language = {{eng}},
number = {{5}},
pages = {{1341--1349}},
publisher = {{Oxford University Press}},
series = {{Brain : a journal of neurology}},
title = {{Relationship between cortical iron and tau aggregation in Alzheimer's disease}},
url = {{http://dx.doi.org/10.1093/brain/awaa089}},
doi = {{10.1093/brain/awaa089}},
volume = {{143}},
year = {{2020}},
}