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Computational anatomy : the cerebellar microzone computation

Gilbert, Mike and Rasmussen, Anders LU orcid (2025) In Oxford open neuroscience 4.
Abstract

The cerebellum is a large brain structure. Most of the mass and volume of the cerebellum is made up by the cerebellar cortex. The outer layer of the cerebellar cortex is divided functionally into long, thin strips called microzones. We argue that the cerebellar microzone computation is the aggregate of simple unit computations and a passive effect of anatomy, unaided and unlearned, which we recreate
in silico. This is likely to polarise opinion. In the traditional view, data processing by the cerebellum (stated very briefly) is the effect of learned synaptic changes. However, this has become difficult to reconcile with evidence that rate information is linearly conserved in cerebellar signalling. We present an alternative... (More)

The cerebellum is a large brain structure. Most of the mass and volume of the cerebellum is made up by the cerebellar cortex. The outer layer of the cerebellar cortex is divided functionally into long, thin strips called microzones. We argue that the cerebellar microzone computation is the aggregate of simple unit computations and a passive effect of anatomy, unaided and unlearned, which we recreate
in silico. This is likely to polarise opinion. In the traditional view, data processing by the cerebellum (stated very briefly) is the effect of learned synaptic changes. However, this has become difficult to reconcile with evidence that rate information is linearly conserved in cerebellar signalling. We present an alternative interpretation of cell morphologies and network architecture in the light of linear communication. Parallel fibre synaptic memory has a supporting role in the network computation.

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Oxford open neuroscience
volume
4
article number
kvaf001
external identifiers
  • pmid:40401259
ISSN
2753-149X
DOI
10.1093/oons/kvaf001
language
English
LU publication?
yes
additional info
© The Author(s) 2025. Published by Oxford University Press.
id
f4795787-49b3-4ecd-8216-9db54154ea7d
date added to LUP
2025-05-26 08:14:05
date last changed
2025-05-26 08:59:24
@article{f4795787-49b3-4ecd-8216-9db54154ea7d,
  abstract     = {{<p>The cerebellum is a large brain structure. Most of the mass and volume of the cerebellum is made up by the cerebellar cortex. The outer layer of the cerebellar cortex is divided functionally into long, thin strips called microzones. We argue that the cerebellar microzone computation is the aggregate of simple unit computations and a passive effect of anatomy, unaided and unlearned, which we recreate<br>
 in silico. This is likely to polarise opinion. In the traditional view, data processing by the cerebellum (stated very briefly) is the effect of learned synaptic changes. However, this has become difficult to reconcile with evidence that rate information is linearly conserved in cerebellar signalling. We present an alternative interpretation of cell morphologies and network architecture in the light of linear communication. Parallel fibre synaptic memory has a supporting role in the network computation.<br>
 </p>}},
  author       = {{Gilbert, Mike and Rasmussen, Anders}},
  issn         = {{2753-149X}},
  language     = {{eng}},
  series       = {{Oxford open neuroscience}},
  title        = {{Computational anatomy : the cerebellar microzone computation}},
  url          = {{http://dx.doi.org/10.1093/oons/kvaf001}},
  doi          = {{10.1093/oons/kvaf001}},
  volume       = {{4}},
  year         = {{2025}},
}