Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy : Experience from the Nordic ARVC Registry

Baturova, Maria A. LU ; Haugaa, Kristina H. ; Jensen, Henrik K. ; Svensson, Anneli LU ; Gilljam, Thomas ; Bundgaard, Henning ; Madsen, Trine ; Hansen, Jim ; Chivulescu, Monica and Christiansen, Morten Krogh , et al. (2020) In International Journal of Cardiology 298. p.39-43
Abstract

Background: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestations. Methods: Study sample comprised of 293 definite ARVC patients by 2010 Task Force criteria (TFC2010) and 141 genotype-positive family members (total n = 434, 43% females, median age at ARVC diagnosis 41 years [interquartile range (IQR) 28–52 years]). ARVC diagnostic score was calculated as the sum of major (2 points) and minor (1 point)... (More)

Background: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestations. Methods: Study sample comprised of 293 definite ARVC patients by 2010 Task Force criteria (TFC2010) and 141 genotype-positive family members (total n = 434, 43% females, median age at ARVC diagnosis 41 years [interquartile range (IQR) 28–52 years]). ARVC diagnostic score was calculated as the sum of major (2 points) and minor (1 point) criteria in all categories of the TFC2010. Results: AF was diagnosed in 42 patients (10%): in 41 patients with definite ARVC diagnosis (14%) vs in one genotype-positive family member (1%), p < 0.001. The median age at AF onset was 51 (IQR 38–58) years. The prevalence of AF was related to the ARVC diagnostic score: it significantly increased starting with the diagnostic score 4 (2% in those with score 3 vs 13% in those with score 4, p = 0.023) and increased further with increased diagnostic score (Somer's d value is 0.074, p < 0.001). Conclusion: AF is seen in 14% of definite ARVC patients and is related to the severity of disease phenotype thus suggesting AF being an arrhythmic manifestation of this cardiomyopathy indicating atrial myocardial involvement in the disease progression.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arrhythmogenic cardiomyopathy, Atrial fibrillation, Diagnostic score
in
International Journal of Cardiology
volume
298
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:85077103190
  • pmid:31387820
ISSN
0167-5273
DOI
10.1016/j.ijcard.2019.07.086
language
English
LU publication?
yes
id
f5264605-d4ab-4815-b9b2-05a9e395e570
date added to LUP
2020-01-10 12:10:16
date last changed
2024-02-16 08:55:47
@article{f5264605-d4ab-4815-b9b2-05a9e395e570,
  abstract     = {{<p>Background: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestations. Methods: Study sample comprised of 293 definite ARVC patients by 2010 Task Force criteria (TFC2010) and 141 genotype-positive family members (total n = 434, 43% females, median age at ARVC diagnosis 41 years [interquartile range (IQR) 28–52 years]). ARVC diagnostic score was calculated as the sum of major (2 points) and minor (1 point) criteria in all categories of the TFC2010. Results: AF was diagnosed in 42 patients (10%): in 41 patients with definite ARVC diagnosis (14%) vs in one genotype-positive family member (1%), p &lt; 0.001. The median age at AF onset was 51 (IQR 38–58) years. The prevalence of AF was related to the ARVC diagnostic score: it significantly increased starting with the diagnostic score 4 (2% in those with score 3 vs 13% in those with score 4, p = 0.023) and increased further with increased diagnostic score (Somer's d value is 0.074, p &lt; 0.001). Conclusion: AF is seen in 14% of definite ARVC patients and is related to the severity of disease phenotype thus suggesting AF being an arrhythmic manifestation of this cardiomyopathy indicating atrial myocardial involvement in the disease progression.</p>}},
  author       = {{Baturova, Maria A. and Haugaa, Kristina H. and Jensen, Henrik K. and Svensson, Anneli and Gilljam, Thomas and Bundgaard, Henning and Madsen, Trine and Hansen, Jim and Chivulescu, Monica and Christiansen, Morten Krogh and Carlson, Jonas and Edvardsen, Thor and Svendsen, Jesper H. and Platonov, Pyotr G.}},
  issn         = {{0167-5273}},
  keywords     = {{Arrhythmogenic cardiomyopathy; Atrial fibrillation; Diagnostic score}},
  language     = {{eng}},
  pages        = {{39--43}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Cardiology}},
  title        = {{Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy : Experience from the Nordic ARVC Registry}},
  url          = {{http://dx.doi.org/10.1016/j.ijcard.2019.07.086}},
  doi          = {{10.1016/j.ijcard.2019.07.086}},
  volume       = {{298}},
  year         = {{2020}},
}