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Interaction of quercetin and epigallocatechin gallate (EGCG) aggregates with pancreatic lipase under simplified intestinal conditions

Bustos, Atma-Sol LU ; Håkansson, Andreas LU ; Linares-Pastén, Javier A LU orcid ; Peñarrieta, J Mauricio and Nilsson, Lars LU (2020) In PLoS ONE 15(4). p.0224853-0224853
Abstract

Diets rich in flavonoids have been related with low obesity rates, which could be related with their potential to inhibit pancreatic lipase, the main enzyme of fat assimilation. Some flavonoids can aggregate in aqueous medium suggesting that the inhibition mechanism could occur on both molecular and colloidal levels. This study investigates the interaction of two flavonoid aggregates, quercetin and epigallocatechin gallate (EGCG), with pancreatic lipase under simplified intestinal conditions. The stability and the morphology of these flavonoid aggregates were studied in four different solutions: Control (water), salt, low lipase concentration and high lipase concentration. Particles were found by optical microscopy in almost all the... (More)

Diets rich in flavonoids have been related with low obesity rates, which could be related with their potential to inhibit pancreatic lipase, the main enzyme of fat assimilation. Some flavonoids can aggregate in aqueous medium suggesting that the inhibition mechanism could occur on both molecular and colloidal levels. This study investigates the interaction of two flavonoid aggregates, quercetin and epigallocatechin gallate (EGCG), with pancreatic lipase under simplified intestinal conditions. The stability and the morphology of these flavonoid aggregates were studied in four different solutions: Control (water), salt, low lipase concentration and high lipase concentration. Particles were found by optical microscopy in almost all the solutions tested, except EGCG-control. The results show that the precipitation rate decreases for quercetin and increases for EGCG in salt solution and that lipase stabilize quercetin aggregates. In addition, both flavonoids were shown to precipitate together with pancreatic lipase resulting in a sequestering of the enzyme.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
15
issue
4
pages
0224853 - 0224853
publisher
Public Library of Science (PLoS)
external identifiers
  • scopus:85083506198
  • pmid:32298262
ISSN
1932-6203
DOI
10.1371/journal.pone.0224853
language
English
LU publication?
yes
id
f5f0eea6-5713-4f0b-be10-7c5c6828643d
date added to LUP
2020-04-21 06:20:57
date last changed
2024-05-02 07:48:45
@article{f5f0eea6-5713-4f0b-be10-7c5c6828643d,
  abstract     = {{<p>Diets rich in flavonoids have been related with low obesity rates, which could be related with their potential to inhibit pancreatic lipase, the main enzyme of fat assimilation. Some flavonoids can aggregate in aqueous medium suggesting that the inhibition mechanism could occur on both molecular and colloidal levels. This study investigates the interaction of two flavonoid aggregates, quercetin and epigallocatechin gallate (EGCG), with pancreatic lipase under simplified intestinal conditions. The stability and the morphology of these flavonoid aggregates were studied in four different solutions: Control (water), salt, low lipase concentration and high lipase concentration. Particles were found by optical microscopy in almost all the solutions tested, except EGCG-control. The results show that the precipitation rate decreases for quercetin and increases for EGCG in salt solution and that lipase stabilize quercetin aggregates. In addition, both flavonoids were shown to precipitate together with pancreatic lipase resulting in a sequestering of the enzyme.</p>}},
  author       = {{Bustos, Atma-Sol and Håkansson, Andreas and Linares-Pastén, Javier A and Peñarrieta, J Mauricio and Nilsson, Lars}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{0224853--0224853}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Interaction of quercetin and epigallocatechin gallate (EGCG) aggregates with pancreatic lipase under simplified intestinal conditions}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0224853}},
  doi          = {{10.1371/journal.pone.0224853}},
  volume       = {{15}},
  year         = {{2020}},
}