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Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

Ståhl, Anne lie LU ; Johansson, Karl LU ; Mossberg, Maria LU ; Kahn, Robin LU and Karpman, Diana LU (2017) In Pediatric Nephrology
Abstract

Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in size, including exosomes, microvesicles, and apoptotic bodies. They are released under physiological conditions, but also upon cellular activation, senescence, and apoptosis. They play an important role in intercellular communication. Their release may also maintain cellular integrity by ridding the cell of damaging substances. This review describes the biogenesis, uptake, and detection of extracellular vesicles in addition to the impact that they have on recipient cells, focusing on mechanisms important in the pathophysiology of kidney diseases, such as thrombosis, angiogenesis, tissue regeneration, immune modulation, and inflammation. In kidney... (More)

Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in size, including exosomes, microvesicles, and apoptotic bodies. They are released under physiological conditions, but also upon cellular activation, senescence, and apoptosis. They play an important role in intercellular communication. Their release may also maintain cellular integrity by ridding the cell of damaging substances. This review describes the biogenesis, uptake, and detection of extracellular vesicles in addition to the impact that they have on recipient cells, focusing on mechanisms important in the pathophysiology of kidney diseases, such as thrombosis, angiogenesis, tissue regeneration, immune modulation, and inflammation. In kidney diseases, extracellular vesicles may be utilized as biomarkers, as they are detected in both blood and urine. Furthermore, they may contribute to the pathophysiology of renal disease while also having beneficial effects associated with tissue repair. Because of their role in the promotion of thrombosis, inflammation, and immune-mediated disease, they could be the target of drug therapy, whereas their favorable effects could be utilized therapeutically in acute and chronic kidney injury.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Exosomes, Extracellular vesicles, Inflammation, Kidney, Microvesicles, Thrombosis
in
Pediatric Nephrology
pages
20 pages
publisher
Springer
external identifiers
  • scopus:85035102725
ISSN
0931-041X
DOI
10.1007/s00467-017-3816-z
language
English
LU publication?
yes
id
f64bcde2-c38f-4648-bf1a-09a66e77e807
date added to LUP
2017-12-14 14:27:08
date last changed
2018-01-07 12:28:53
@article{f64bcde2-c38f-4648-bf1a-09a66e77e807,
  abstract     = {<p>Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in size, including exosomes, microvesicles, and apoptotic bodies. They are released under physiological conditions, but also upon cellular activation, senescence, and apoptosis. They play an important role in intercellular communication. Their release may also maintain cellular integrity by ridding the cell of damaging substances. This review describes the biogenesis, uptake, and detection of extracellular vesicles in addition to the impact that they have on recipient cells, focusing on mechanisms important in the pathophysiology of kidney diseases, such as thrombosis, angiogenesis, tissue regeneration, immune modulation, and inflammation. In kidney diseases, extracellular vesicles may be utilized as biomarkers, as they are detected in both blood and urine. Furthermore, they may contribute to the pathophysiology of renal disease while also having beneficial effects associated with tissue repair. Because of their role in the promotion of thrombosis, inflammation, and immune-mediated disease, they could be the target of drug therapy, whereas their favorable effects could be utilized therapeutically in acute and chronic kidney injury.</p>},
  author       = {Ståhl, Anne lie and Johansson, Karl and Mossberg, Maria and Kahn, Robin and Karpman, Diana},
  issn         = {0931-041X},
  keyword      = {Exosomes,Extracellular vesicles,Inflammation,Kidney,Microvesicles,Thrombosis},
  language     = {eng},
  month        = {11},
  pages        = {20},
  publisher    = {Springer},
  series       = {Pediatric Nephrology},
  title        = {Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases},
  url          = {http://dx.doi.org/10.1007/s00467-017-3816-z},
  year         = {2017},
}