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Pathological airway remodelling in inflammation

Westergren-Thorsson, Gunilla LU ; Larsen, Kristoffer LU ; Nihlberg, Kristian LU ; Andersson Sjöland, Annika LU ; Hallgren, Oskar LU ; Marko-Varga, György LU and Bjermer, Leif LU (2010) In Clinical Respiratory Journal 4(s1). p.1-8
Abstract
Introduction: Airway remodelling refers to a wide pattern of patophysiological mechanisms involving smooth muscle cell hyperplasia, increase of activated fibroblasts and myofibroblasts with deposition of extracellular matrix. In asthma, it includes alterations of the epithelial cell layer with goblet cell hyperplasia, thickening of basement membranes, peri-bronchial and peri-broncheolar fibrosis. Moreover, airway remodelling occurs not only in asthma but also in several pulmonary disorders such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and systemic sclerosis. Asthma treatment with inhaled corticosteroids does not fully prevent airway remodelling and thus have restricted influence on the natural course of the... (More)
Introduction: Airway remodelling refers to a wide pattern of patophysiological mechanisms involving smooth muscle cell hyperplasia, increase of activated fibroblasts and myofibroblasts with deposition of extracellular matrix. In asthma, it includes alterations of the epithelial cell layer with goblet cell hyperplasia, thickening of basement membranes, peri-bronchial and peri-broncheolar fibrosis. Moreover, airway remodelling occurs not only in asthma but also in several pulmonary disorders such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and systemic sclerosis. Asthma treatment with inhaled corticosteroids does not fully prevent airway remodelling and thus have restricted influence on the natural course of the disease. Objectives: This review highlights the role of different fibroblast phenotypes and potential origins of these cells in airway remodelling. Results: During inflammatory conditions, such as asthma, fibroblasts can differentiate into an active, more contractile phenotype termed myofibroblast, with expression of stress fibres and alpha-smooth muscle actin. The origin of myofibroblasts has lately been debated, and three sources have been identified: recruitment and differentiation of resident tissue fibroblasts; fibrocytes - circulating progenitor cells; and epithelial-mesenchymal transition. Conclusion: It is clear that airway mesenchymal cells, including fibroblasts/myofibroblasts, are more dynamic in terms of differentiation and origin than has previously been recognised. Considering that these cells are key players in the remodelling process, it is of utmost importance to characterise specific markers for the various fibroblast phenotypes and to explore factors that drive the differentiation to develop future diagnostic and therapeutic tools for asthma patients. Please cite this paper as: Westergren-Thorsson G, Larsen K, Nihlberg K, Andersson-Sjoland A, Hallgren O, Marko-Varga G and Bjermer L. Pathological airway remodelling in inflammation. Clin Respir J 2010; 4 (Suppl. 1): 1-8. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
fibrocyte, fibroblast, extracellular matrix, airway remodelling, asthma
in
Clinical Respiratory Journal
volume
4
issue
s1
pages
1 - 8
publisher
Wiley-Blackwell
external identifiers
  • wos:000276695800001
  • pmid:20500603
  • scopus:77951128490
ISSN
1752-6981
DOI
10.1111/j.1752-699X.2010.00190.x
language
English
LU publication?
yes
id
f7ad7de6-c470-4d96-aad9-cc06f3ccf144 (old id 1603196)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20500603?dopt=Abstract
date added to LUP
2010-05-19 09:24:25
date last changed
2018-10-03 11:15:58
@article{f7ad7de6-c470-4d96-aad9-cc06f3ccf144,
  abstract     = {Introduction: Airway remodelling refers to a wide pattern of patophysiological mechanisms involving smooth muscle cell hyperplasia, increase of activated fibroblasts and myofibroblasts with deposition of extracellular matrix. In asthma, it includes alterations of the epithelial cell layer with goblet cell hyperplasia, thickening of basement membranes, peri-bronchial and peri-broncheolar fibrosis. Moreover, airway remodelling occurs not only in asthma but also in several pulmonary disorders such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and systemic sclerosis. Asthma treatment with inhaled corticosteroids does not fully prevent airway remodelling and thus have restricted influence on the natural course of the disease. Objectives: This review highlights the role of different fibroblast phenotypes and potential origins of these cells in airway remodelling. Results: During inflammatory conditions, such as asthma, fibroblasts can differentiate into an active, more contractile phenotype termed myofibroblast, with expression of stress fibres and alpha-smooth muscle actin. The origin of myofibroblasts has lately been debated, and three sources have been identified: recruitment and differentiation of resident tissue fibroblasts; fibrocytes - circulating progenitor cells; and epithelial-mesenchymal transition. Conclusion: It is clear that airway mesenchymal cells, including fibroblasts/myofibroblasts, are more dynamic in terms of differentiation and origin than has previously been recognised. Considering that these cells are key players in the remodelling process, it is of utmost importance to characterise specific markers for the various fibroblast phenotypes and to explore factors that drive the differentiation to develop future diagnostic and therapeutic tools for asthma patients. Please cite this paper as: Westergren-Thorsson G, Larsen K, Nihlberg K, Andersson-Sjoland A, Hallgren O, Marko-Varga G and Bjermer L. Pathological airway remodelling in inflammation. Clin Respir J 2010; 4 (Suppl. 1): 1-8.},
  author       = {Westergren-Thorsson, Gunilla and Larsen, Kristoffer and Nihlberg, Kristian and Andersson Sjöland, Annika and Hallgren, Oskar and Marko-Varga, György and Bjermer, Leif},
  issn         = {1752-6981},
  keyword      = {fibrocyte,fibroblast,extracellular matrix,airway remodelling,asthma},
  language     = {eng},
  number       = {s1},
  pages        = {1--8},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Respiratory Journal},
  title        = {Pathological airway remodelling in inflammation},
  url          = {http://dx.doi.org/10.1111/j.1752-699X.2010.00190.x},
  volume       = {4},
  year         = {2010},
}