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Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer : A pooled analysis of data from two prospective cohort studies

Jayasekara, Harindra ; MacInnis, Robert J. ; Lujan-Barroso, Leila ; Mayen-Chacon, Ana Lucia ; Cross, Amanda J. ; Wallner, Bengt ; Palli, Domenico ; Ricceri, Fulvio ; Pala, Valeria and Panico, Salvatore , et al. (2021) In International Journal of Cancer 148(11). p.2759-2773
Abstract

Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78%... (More)

Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity =.02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardia cancer, EPIC, lifetime alcohol intake, MCCS, noncardia cancer, stomach cancer
in
International Journal of Cancer
volume
148
issue
11
pages
2759 - 2773
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85101271312
  • pmid:33554339
ISSN
0020-7136
DOI
10.1002/ijc.33504
language
English
LU publication?
yes
id
f7e9b176-5895-4e5b-b3dd-16e8d8a6a6f7
date added to LUP
2021-03-11 10:20:17
date last changed
2024-06-13 08:21:11
@article{f7e9b176-5895-4e5b-b3dd-16e8d8a6a6f7,
  abstract     = {{<p>Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (P<sub>homogeneity</sub> =.02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.</p>}},
  author       = {{Jayasekara, Harindra and MacInnis, Robert J. and Lujan-Barroso, Leila and Mayen-Chacon, Ana Lucia and Cross, Amanda J. and Wallner, Bengt and Palli, Domenico and Ricceri, Fulvio and Pala, Valeria and Panico, Salvatore and Tumino, Rosario and Kühn, Tilman and Kaaks, Rudolf and Tsilidis, Kostas and Sánchez, Maria Jose and Amiano, Pilar and Ardanaz, Eva and Chirlaque López, María Dolores and Merino, Susana and Rothwell, Joseph A. and Boutron-Ruault, Marie Christine and Severi, Gianluca and Sternby, Hanna and Sonestedt, Emily and Bueno-de-Mesquita, Bas and Boeing, Heiner and Travis, Ruth and Sandanger, Torkjel M. and Trichopoulou, Antonia and Karakatsani, Anna and Peppa, Eleni and Tjønneland, Anne and Yang, Yi and Hodge, Allison M. and Mitchell, Hazel and Haydon, Andrew and Room, Robin and Hopper, John L. and Weiderpass, Elisabete and Gunter, Marc J. and Riboli, Elio and Giles, Graham G. and Milne, Roger L. and Agudo, Antonio and English, Dallas R. and Ferrari, Pietro}},
  issn         = {{0020-7136}},
  keywords     = {{cardia cancer; EPIC; lifetime alcohol intake; MCCS; noncardia cancer; stomach cancer}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{11}},
  pages        = {{2759--2773}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer : A pooled analysis of data from two prospective cohort studies}},
  url          = {{http://dx.doi.org/10.1002/ijc.33504}},
  doi          = {{10.1002/ijc.33504}},
  volume       = {{148}},
  year         = {{2021}},
}