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Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis 16 years after anterior cruciate ligament injury

Neuman, P. LU ; Dahlberg, L. E. LU ; Englund, M. LU orcid and Struglics, A. LU (2017) In Osteoarthritis and Cartilage 25(4). p.492-498
Abstract

Objective: To describe the longitudinal patterns of release, and investigate the association between a set of synovial fluid biomarkers at the acute and chronic stage and the development of radiographic knee osteoarthritis (OA) after an anterior cruciate ligament (ACL) injury. Design: Synovial fluid was aspirated from the acutely ACL-injured knee within the first 2weeks (acute samples), and yearly (chronic samples) up to 7.5 years after injury in 88 subjects (60% men). Non-injured subjects (n = 12) were used as reference group. Aggrecan, cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 in synovial fluid were quantified by immunoassays. The presence of... (More)

Objective: To describe the longitudinal patterns of release, and investigate the association between a set of synovial fluid biomarkers at the acute and chronic stage and the development of radiographic knee osteoarthritis (OA) after an anterior cruciate ligament (ACL) injury. Design: Synovial fluid was aspirated from the acutely ACL-injured knee within the first 2weeks (acute samples), and yearly (chronic samples) up to 7.5 years after injury in 88 subjects (60% men). Non-injured subjects (n = 12) were used as reference group. Aggrecan, cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 in synovial fluid were quantified by immunoassays. The presence of radiographic tibiofemoral (TF) or patellofemoral (PF) OA [Kellgren and Lawrence (K&L) ≥2] was examined with weight-bearing knee radiography 16 years after the ACL injury. Results: The average acute and chronic SF concentrations of COMP and aggrecan were elevated in comparison with the reference group (P < 0.001). The levels of COMP and aggrecan clearly decreased approximately half a year after the ACL injury, and returned to reference values during the 7.5 years of follow-up. Using logistic regression analysis neither acute nor chronic concentrations of the four biomarkers were associated with the development of radiographic knee OA at the 16 year follow-up. Conclusion: Increased synovial fluid concentrations of aggrecan and COMP was related to knee injury, but acute and chronic synovial fluid concentrations of aggrecan, COMP, MMP-3 and TIMP-1 failed to predict knee OA 16 years after ACL injury.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ACL, Biomarkers, Knee OA, Synovial fluid
in
Osteoarthritis and Cartilage
volume
25
issue
4
pages
492 - 498
publisher
Elsevier
external identifiers
  • pmid:27654964
  • wos:000401093200012
  • scopus:84992188283
ISSN
1063-4584
DOI
10.1016/j.joca.2016.09.008
language
English
LU publication?
yes
id
f84accfc-b20b-4cef-a156-54791ddaf1f3
date added to LUP
2016-11-03 15:09:04
date last changed
2025-01-12 14:20:06
@article{f84accfc-b20b-4cef-a156-54791ddaf1f3,
  abstract     = {{<p>Objective: To describe the longitudinal patterns of release, and investigate the association between a set of synovial fluid biomarkers at the acute and chronic stage and the development of radiographic knee osteoarthritis (OA) after an anterior cruciate ligament (ACL) injury. Design: Synovial fluid was aspirated from the acutely ACL-injured knee within the first 2weeks (acute samples), and yearly (chronic samples) up to 7.5 years after injury in 88 subjects (60% men). Non-injured subjects (n = 12) were used as reference group. Aggrecan, cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 in synovial fluid were quantified by immunoassays. The presence of radiographic tibiofemoral (TF) or patellofemoral (PF) OA [Kellgren and Lawrence (K&amp;L) ≥2] was examined with weight-bearing knee radiography 16 years after the ACL injury. Results: The average acute and chronic SF concentrations of COMP and aggrecan were elevated in comparison with the reference group (P &lt; 0.001). The levels of COMP and aggrecan clearly decreased approximately half a year after the ACL injury, and returned to reference values during the 7.5 years of follow-up. Using logistic regression analysis neither acute nor chronic concentrations of the four biomarkers were associated with the development of radiographic knee OA at the 16 year follow-up. Conclusion: Increased synovial fluid concentrations of aggrecan and COMP was related to knee injury, but acute and chronic synovial fluid concentrations of aggrecan, COMP, MMP-3 and TIMP-1 failed to predict knee OA 16 years after ACL injury.</p>}},
  author       = {{Neuman, P. and Dahlberg, L. E. and Englund, M. and Struglics, A.}},
  issn         = {{1063-4584}},
  keywords     = {{ACL; Biomarkers; Knee OA; Synovial fluid}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{492--498}},
  publisher    = {{Elsevier}},
  series       = {{Osteoarthritis and Cartilage}},
  title        = {{Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis 16 years after anterior cruciate ligament injury}},
  url          = {{http://dx.doi.org/10.1016/j.joca.2016.09.008}},
  doi          = {{10.1016/j.joca.2016.09.008}},
  volume       = {{25}},
  year         = {{2017}},
}