Persistent high prevalence of thyroid antibodies after immunosuppressive therapy in subjects with glomerulonephritis. A prospective three-year follow-up study
(1998) In American Journal of Nephrology 18(4). p.9-274- Abstract
The prevalence of thyroid antibodies, indicating an autoimmune thyroiditis, has been shown to be significantly increased in patients with autoimmune diseases. A 3-year prospective follow-up study of 42 patients with biopsy-confirmed glomerulonephritis is presented. Although the majority of patients had been treated with immunosuppressants, the prevalence of thyroid peroxidase antibodies was unchanged in both females and males, 47 and 15% respectively, at follow-up. Likewise, the prevalence of thyroglobulin antibodies was unaffected as was that of antinuclear antibodies (ANA) when analysing males and females together. However, for males there was a trend to higher prevalence for ANA at follow-up. On the other hand, the prevalence of... (More)
The prevalence of thyroid antibodies, indicating an autoimmune thyroiditis, has been shown to be significantly increased in patients with autoimmune diseases. A 3-year prospective follow-up study of 42 patients with biopsy-confirmed glomerulonephritis is presented. Although the majority of patients had been treated with immunosuppressants, the prevalence of thyroid peroxidase antibodies was unchanged in both females and males, 47 and 15% respectively, at follow-up. Likewise, the prevalence of thyroglobulin antibodies was unaffected as was that of antinuclear antibodies (ANA) when analysing males and females together. However, for males there was a trend to higher prevalence for ANA at follow-up. On the other hand, the prevalence of antineutrophil cytoplasmic antibodies declined. Furthermore, thyroid antibodies were not restricted to membranous nephropathy, and notably found in 4 out of the 8 patients with vasculitis.
(Less)
- author
- Westman, K W LU ; Bygren, P G LU ; Ericsson, U B ; Høier-Madsen, M ; Wieslander, J LU and Erfurth, E M LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Antibodies, Antineutrophil Cytoplasmic/analysis, Autoantibodies/analysis, Female, Follow-Up Studies, Glomerulonephritis/drug therapy, Humans, Immunosuppressive Agents/therapeutic use, Iodide Peroxidase/immunology, Male, Middle Aged, Prevalence, Prospective Studies, Thyroglobulin/immunology, Thyroid Gland/immunology, Thyroiditis, Autoimmune/epidemiology, Time Factors
- in
- American Journal of Nephrology
- volume
- 18
- issue
- 4
- pages
- 9 - 274
- publisher
- Karger
- external identifiers
-
- scopus:0031801115
- pmid:9653829
- ISSN
- 0250-8095
- DOI
- 10.1159/000013350
- language
- English
- LU publication?
- yes
- id
- f88a65f2-639f-429c-817c-07f591745ed2
- date added to LUP
- 2023-11-22 16:03:41
- date last changed
- 2024-02-03 23:02:32
@article{f88a65f2-639f-429c-817c-07f591745ed2,
abstract = {{<p>The prevalence of thyroid antibodies, indicating an autoimmune thyroiditis, has been shown to be significantly increased in patients with autoimmune diseases. A 3-year prospective follow-up study of 42 patients with biopsy-confirmed glomerulonephritis is presented. Although the majority of patients had been treated with immunosuppressants, the prevalence of thyroid peroxidase antibodies was unchanged in both females and males, 47 and 15% respectively, at follow-up. Likewise, the prevalence of thyroglobulin antibodies was unaffected as was that of antinuclear antibodies (ANA) when analysing males and females together. However, for males there was a trend to higher prevalence for ANA at follow-up. On the other hand, the prevalence of antineutrophil cytoplasmic antibodies declined. Furthermore, thyroid antibodies were not restricted to membranous nephropathy, and notably found in 4 out of the 8 patients with vasculitis.</p>}},
author = {{Westman, K W and Bygren, P G and Ericsson, U B and Høier-Madsen, M and Wieslander, J and Erfurth, E M}},
issn = {{0250-8095}},
keywords = {{Adult; Antibodies, Antineutrophil Cytoplasmic/analysis; Autoantibodies/analysis; Female; Follow-Up Studies; Glomerulonephritis/drug therapy; Humans; Immunosuppressive Agents/therapeutic use; Iodide Peroxidase/immunology; Male; Middle Aged; Prevalence; Prospective Studies; Thyroglobulin/immunology; Thyroid Gland/immunology; Thyroiditis, Autoimmune/epidemiology; Time Factors}},
language = {{eng}},
number = {{4}},
pages = {{9--274}},
publisher = {{Karger}},
series = {{American Journal of Nephrology}},
title = {{Persistent high prevalence of thyroid antibodies after immunosuppressive therapy in subjects with glomerulonephritis. A prospective three-year follow-up study}},
url = {{http://dx.doi.org/10.1159/000013350}},
doi = {{10.1159/000013350}},
volume = {{18}},
year = {{1998}},
}