Regulation of Ca2+ channel and phosphatase activities by polyamines in intestinal and vascular smooth muscle - implications for cellular growth and contractility.
Nilsson, Bengt-Olof LU
; Gomez, Maria
LU
; Swärd, Karl
LU
and Hellstrand, Per
LU
(2002)
In Acta Physiologica Scandinavica
176(1).
p.33-41
- Abstract
- Polyamines added extracellularly to intestinal and vascular smooth muscle cells cause relaxation through inhibition of Ca2+ channel activity. Intracellularly applied polyamines also affect Ca2+ channel properties. Polyamines do not readily pass over the plasma membrane because of their positive charges but in permeabilized smooth muscle preparations they have free access to the cytoplasm. In this system they increase sensitivity of the contractile machinery to Ca2+ through inhibition of myosin phosphatase activity. The magnitude of Ca2+ channel and phosphatase inhibition depends on the number of positive charges on the polyamine molecule. Polyamines have an obligatory, but yet undefined, role in regulation of cell growth and proliferation.... (More)
- Polyamines added extracellularly to intestinal and vascular smooth muscle cells cause relaxation through inhibition of Ca2+ channel activity. Intracellularly applied polyamines also affect Ca2+ channel properties. Polyamines do not readily pass over the plasma membrane because of their positive charges but in permeabilized smooth muscle preparations they have free access to the cytoplasm. In this system they increase sensitivity of the contractile machinery to Ca2+ through inhibition of myosin phosphatase activity. The magnitude of Ca2+ channel and phosphatase inhibition depends on the number of positive charges on the polyamine molecule. Polyamines have an obligatory, but yet undefined, role in regulation of cell growth and proliferation. Several groups of protein kinases, such as tyrosine and mitogen activated protein (MAP)-kinases transmit the growth signal from the plasma membrane to the cell nucleus where mitosis and protein synthesis are initiated. The data reviewed here show that polyamines may affect such signal transmission via inhibition of phosphatase activity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/110066
- author
- Nilsson, Bengt-Olof
LU
; Gomez, Maria
LU
; Swärd, Karl
LU
and Hellstrand, Per
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Physiologica Scandinavica
- volume
- 176
- issue
- 1
- pages
- 33 - 41
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000177595600005
- pmid:12193217
- scopus:0035982015
- ISSN
- 0001-6772
- DOI
- 10.1046/j.1365-201X.2002.01013.x
- language
- English
- LU publication?
- yes
- id
- f912113b-86b3-4a3b-b04a-3587d58a96d4 (old id 110066)
- date added to LUP
- 2016-04-01 16:03:41
- date last changed
- 2022-01-28 17:00:48
@article{f912113b-86b3-4a3b-b04a-3587d58a96d4,
abstract = {{Polyamines added extracellularly to intestinal and vascular smooth muscle cells cause relaxation through inhibition of Ca2+ channel activity. Intracellularly applied polyamines also affect Ca2+ channel properties. Polyamines do not readily pass over the plasma membrane because of their positive charges but in permeabilized smooth muscle preparations they have free access to the cytoplasm. In this system they increase sensitivity of the contractile machinery to Ca2+ through inhibition of myosin phosphatase activity. The magnitude of Ca2+ channel and phosphatase inhibition depends on the number of positive charges on the polyamine molecule. Polyamines have an obligatory, but yet undefined, role in regulation of cell growth and proliferation. Several groups of protein kinases, such as tyrosine and mitogen activated protein (MAP)-kinases transmit the growth signal from the plasma membrane to the cell nucleus where mitosis and protein synthesis are initiated. The data reviewed here show that polyamines may affect such signal transmission via inhibition of phosphatase activity.}},
author = {{Nilsson, Bengt-Olof and Gomez, Maria and Swärd, Karl and Hellstrand, Per}},
issn = {{0001-6772}},
language = {{eng}},
number = {{1}},
pages = {{33--41}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Physiologica Scandinavica}},
title = {{Regulation of Ca2+ channel and phosphatase activities by polyamines in intestinal and vascular smooth muscle - implications for cellular growth and contractility.}},
url = {{https://lup.lub.lu.se/search/files/4555328/623649.pdf}},
doi = {{10.1046/j.1365-201X.2002.01013.x}},
volume = {{176}},
year = {{2002}},
}