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Altered behavioural responses and functional recovery in rats following sciatic nerve compression and early vs late decompression

Pettersson, Lina M E LU ; Danielsen, Nils LU and Dahlin, Lars B. LU (2016) In Journal of Plastic Surgery and Hand Surgery 50(6). p.321-330
Abstract

Objective: The aim of the study was to examine sensory behaviour and functional recovery in rats during nerve compression and after decompression. Compression injury is a far more common condition than nerve transection. The condition is characterised by numbness and a tingling/burning sensation, and some patients experience pain and allodynia during compression or after decompression treatment. The aetiology is in many cases unknown. Thus, further studies are of great importance for the understanding of this condition. Methods: In the present study, behavioural responses to tactile stimulation, thermal pain, as well as functional sensorimotor behaviour were investigated in rats before, during severe compression, and after... (More)

Objective: The aim of the study was to examine sensory behaviour and functional recovery in rats during nerve compression and after decompression. Compression injury is a far more common condition than nerve transection. The condition is characterised by numbness and a tingling/burning sensation, and some patients experience pain and allodynia during compression or after decompression treatment. The aetiology is in many cases unknown. Thus, further studies are of great importance for the understanding of this condition. Methods: In the present study, behavioural responses to tactile stimulation, thermal pain, as well as functional sensorimotor behaviour were investigated in rats before, during severe compression, and after decompression. The sciatic nerve of the rats was experimentally compressed for 3 or 28 days, whereafter surgical release, i.e. decompression, of the nerve was performed and the rats were examined up to ∼9 weeks. Results: An altered behaviour was found in response to compression injury, which is mitigated after early decompression treatment. Conclusions: These findings indicate that early intervention during severe compression injuries is of great importance for recovery and restoration of nerve function and, thus, should have an impact on clinical routines regarding treatment of compression injuries.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allodynia, decompression, hyperalgesia, nerve compression, Nerve injury, pain, sensorimotor behaviour
in
Journal of Plastic Surgery and Hand Surgery
volume
50
issue
6
pages
321 - 330
publisher
Taylor & Francis
external identifiers
  • Scopus:84964523447
ISSN
2000-656X
DOI
10.3109/2000656X.2016.1168742
language
English
LU publication?
yes
id
f963dbf1-5894-4655-88c8-953661c381ad
date added to LUP
2016-06-02 10:45:04
date last changed
2017-01-17 15:32:27
@article{f963dbf1-5894-4655-88c8-953661c381ad,
  abstract     = {<p>Objective: The aim of the study was to examine sensory behaviour and functional recovery in rats during nerve compression and after decompression. Compression injury is a far more common condition than nerve transection. The condition is characterised by numbness and a tingling/burning sensation, and some patients experience pain and allodynia during compression or after decompression treatment. The aetiology is in many cases unknown. Thus, further studies are of great importance for the understanding of this condition. Methods: In the present study, behavioural responses to tactile stimulation, thermal pain, as well as functional sensorimotor behaviour were investigated in rats before, during severe compression, and after decompression. The sciatic nerve of the rats was experimentally compressed for 3 or 28 days, whereafter surgical release, i.e. decompression, of the nerve was performed and the rats were examined up to ∼9 weeks. Results: An altered behaviour was found in response to compression injury, which is mitigated after early decompression treatment. Conclusions: These findings indicate that early intervention during severe compression injuries is of great importance for recovery and restoration of nerve function and, thus, should have an impact on clinical routines regarding treatment of compression injuries.</p>},
  author       = {Pettersson, Lina M E and Danielsen, Nils and Dahlin, Lars B.},
  issn         = {2000-656X},
  keyword      = {allodynia,decompression,hyperalgesia,nerve compression,Nerve injury,pain,sensorimotor behaviour},
  language     = {eng},
  number       = {6},
  pages        = {321--330},
  publisher    = {Taylor & Francis},
  series       = {Journal of Plastic Surgery and Hand Surgery},
  title        = {Altered behavioural responses and functional recovery in rats following sciatic nerve compression and early vs late decompression},
  url          = {http://dx.doi.org/10.3109/2000656X.2016.1168742},
  volume       = {50},
  year         = {2016},
}