Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birth.
Elfving, Maria LU ; Lindberg, Bengt LU ; Lynch, Kristian LU ; Månsson, Majvi LU ; Sundkvist, Göran LU ; Lernmark, Åke LU
and Ivarsson, Sten A
(2008)
In Pediatric Diabetes
9.
p.127-134
- Abstract
- Objective: Cord blood islet autoantibodies in children born to mothers with type 1 diabetes may be associated with a reduced risk of islet autoimmunity and diabetes. The aim of this study was to investigate in children with type 1 diabetes but born to non-diabetic mothers whether islet autoantibodies at birth affected their presence at diagnosis. Patients and methods: Serum samples at birth and at diagnosis were available from 141 children who developed type 1 diabetes between 1 and 19 yr of age (median 9.0 yr; male/female ratio 83/58). The samples were tested for autoantibodies against glutamic acid decarboxylase, insulinoma-associated antigen 2, and insulin as well as for islet cell antibodies. The human leukocyte antigen genotype was... (More)
- Objective: Cord blood islet autoantibodies in children born to mothers with type 1 diabetes may be associated with a reduced risk of islet autoimmunity and diabetes. The aim of this study was to investigate in children with type 1 diabetes but born to non-diabetic mothers whether islet autoantibodies at birth affected their presence at diagnosis. Patients and methods: Serum samples at birth and at diagnosis were available from 141 children who developed type 1 diabetes between 1 and 19 yr of age (median 9.0 yr; male/female ratio 83/58). The samples were tested for autoantibodies against glutamic acid decarboxylase, insulinoma-associated antigen 2, and insulin as well as for islet cell antibodies. The human leukocyte antigen genotype was also determined. Results: The frequency of islet autoantibodies in the umbilical cord blood was 11% compared with 91% at diagnosis. Children with fewer islet autoantibodies at diagnosis were more likely to have had autoantibodies at birth (p = 0.02). Autoantibodies present in cord blood at birth were observed in 25% (3/12) of children with no islet autoantibodies at diagnosis, in 17% (7/42) of children with one or two antibodies at diagnosis, and in only 5% (4/86) of children with more than two antibodies, demonstrating an inverse relationship between autoantibodies at birth and at diagnosis (test for trend, p < 0.001). Conclusions: Our preliminary data suggest that exposure to cord blood islet autoantibodies may influence the presence of islet autoantibodies at the time of diagnosis of type 1 diabetes and explain why some type 1 diabetes children are islet autoantibody negative at clinical diagnosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1021095
- author
- Elfving, Maria
LU
; Lindberg, Bengt
LU
; Lynch, Kristian
LU
; Månsson, Majvi
LU
; Sundkvist, Göran
LU
; Lernmark, Åke
LU
and Ivarsson, Sten A
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Diabetes
- volume
- 9
- pages
- 127 - 134
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:18221435
- wos:000255130400009
- scopus:40349109458
- pmid:18221435
- ISSN
- 1399-543X
- DOI
- 10.1111/j.1399-5448.2007.00349.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Diabetes and Celiac Unit (013241540), Paediatric Endocrinology Research Group (013243010), Diabetes Epidemiology and Neuropathy (013241560)
- id
- f9ca340c-f67a-48b4-82eb-9cdb9b98807b (old id 1021095)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18221435?dopt=Abstract
- date added to LUP
- 2016-04-04 08:05:19
- date last changed
- 2022-01-29 02:59:54
@article{f9ca340c-f67a-48b4-82eb-9cdb9b98807b,
abstract = {{Objective: Cord blood islet autoantibodies in children born to mothers with type 1 diabetes may be associated with a reduced risk of islet autoimmunity and diabetes. The aim of this study was to investigate in children with type 1 diabetes but born to non-diabetic mothers whether islet autoantibodies at birth affected their presence at diagnosis. Patients and methods: Serum samples at birth and at diagnosis were available from 141 children who developed type 1 diabetes between 1 and 19 yr of age (median 9.0 yr; male/female ratio 83/58). The samples were tested for autoantibodies against glutamic acid decarboxylase, insulinoma-associated antigen 2, and insulin as well as for islet cell antibodies. The human leukocyte antigen genotype was also determined. Results: The frequency of islet autoantibodies in the umbilical cord blood was 11% compared with 91% at diagnosis. Children with fewer islet autoantibodies at diagnosis were more likely to have had autoantibodies at birth (p = 0.02). Autoantibodies present in cord blood at birth were observed in 25% (3/12) of children with no islet autoantibodies at diagnosis, in 17% (7/42) of children with one or two antibodies at diagnosis, and in only 5% (4/86) of children with more than two antibodies, demonstrating an inverse relationship between autoantibodies at birth and at diagnosis (test for trend, p < 0.001). Conclusions: Our preliminary data suggest that exposure to cord blood islet autoantibodies may influence the presence of islet autoantibodies at the time of diagnosis of type 1 diabetes and explain why some type 1 diabetes children are islet autoantibody negative at clinical diagnosis.}},
author = {{Elfving, Maria and Lindberg, Bengt and Lynch, Kristian and Månsson, Majvi and Sundkvist, Göran and Lernmark, Åke and Ivarsson, Sten A}},
issn = {{1399-543X}},
language = {{eng}},
pages = {{127--134}},
publisher = {{Wiley-Blackwell}},
series = {{Pediatric Diabetes}},
title = {{Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birth.}},
url = {{http://dx.doi.org/10.1111/j.1399-5448.2007.00349.x}},
doi = {{10.1111/j.1399-5448.2007.00349.x}},
volume = {{9}},
year = {{2008}},
}