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Association between anthropometry and lifestyle factors and risk of B-cell lymphoma : An exposome-wide analysis

Saberi Hosnijeh, Fatemeh ; Casabonne, Delphine ; Nieters, Alexandra ; Solans, Marta ; Naudin, Sabine ; Ferrari, Pietro ; Mckay, James D. ; Benavente, Yolanda ; Weiderpass, Elisabete and Freisling, Heinz , et al. (2021) In International Journal of Cancer 148(9). p.2115-2128
Abstract

To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma... (More)

To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
exposome, exposome-wide association study, lifestyle, lymphoma, prospective study
in
International Journal of Cancer
volume
148
issue
9
pages
2115 - 2128
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:33128820
  • scopus:85096636898
ISSN
0020-7136
DOI
10.1002/ijc.33369
language
English
LU publication?
yes
id
fa89de98-6d0e-41fa-a33d-d6767dd9a039
date added to LUP
2020-12-09 10:43:53
date last changed
2024-04-17 20:39:00
@article{fa89de98-6d0e-41fa-a33d-d6767dd9a039,
  abstract     = {{<p>To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.</p>}},
  author       = {{Saberi Hosnijeh, Fatemeh and Casabonne, Delphine and Nieters, Alexandra and Solans, Marta and Naudin, Sabine and Ferrari, Pietro and Mckay, James D. and Benavente, Yolanda and Weiderpass, Elisabete and Freisling, Heinz and Severi, Gianluca and Boutron Ruault, Marie Christine and Besson, Caroline and Agnoli, Claudia and Masala, Giovanna and Sacerdote, Carlotta and Tumino, Rosario and Huerta, José María and Amiano, Pilar and Rodriguez-Barranco, Miguel and Bonet, Catalina and Barricarte, Aurelio and Christakoudi, Sofia and Knuppel, Anika and Bueno-de-Mesquita, Bas and Schulze, Matthias B. and Kaaks, Rudolf and Canzian, Federico and Späth, Florentin and Jerkeman, Mats and Rylander, Charlotta and Tjønneland, Anne and Olsen, Anja and Borch, Kristin Benjaminsen and Vermeulen, Roel}},
  issn         = {{0020-7136}},
  keywords     = {{exposome; exposome-wide association study; lifestyle; lymphoma; prospective study}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{2115--2128}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Association between anthropometry and lifestyle factors and risk of B-cell lymphoma : An exposome-wide analysis}},
  url          = {{http://dx.doi.org/10.1002/ijc.33369}},
  doi          = {{10.1002/ijc.33369}},
  volume       = {{148}},
  year         = {{2021}},
}