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Comparison of MUC4 expression in primary pancreatic cancer and paired lymph node metastases.

Ansari, Daniel LU ; Urey, Carlos LU ; Gundewar, Chinmay LU ; Bauden, Monika LU and Andersson, Roland LU (2013) In Scandinavian Journal of Gastroenterology 48(10). p.1183-1187
Abstract
Abstract Objective. Mucin 4 (MUC4) is a transmembrane glycoprotein that is expressed in pancreatic ductal adenocarcinoma (PDAC), but not in normal pancreatic tissue. MUC4 has a proposed role in pancreatic tumor progression and metastasis. The purpose of this pilot study was to investigate MUC4 expression during PDAC metastasis by comparing the expression in the primary tumor and paired lymph node metastases from the same patient. Material and methods. Surgical specimens from 17 cases of primary PDAC and paired lymph node metastases were immunohistochemically analyzed for MUC4 expression. The modified histochemical score (H-score) was used for staining assessment. Results. Positive staining for MUC4 was detected in most primary and... (More)
Abstract Objective. Mucin 4 (MUC4) is a transmembrane glycoprotein that is expressed in pancreatic ductal adenocarcinoma (PDAC), but not in normal pancreatic tissue. MUC4 has a proposed role in pancreatic tumor progression and metastasis. The purpose of this pilot study was to investigate MUC4 expression during PDAC metastasis by comparing the expression in the primary tumor and paired lymph node metastases from the same patient. Material and methods. Surgical specimens from 17 cases of primary PDAC and paired lymph node metastases were immunohistochemically analyzed for MUC4 expression. The modified histochemical score (H-score) was used for staining assessment. Results. Positive staining for MUC4 was detected in most primary and metastatic PDAC tumors (15/17 vs. 14/17). The concordance for MUC4 expression in primary tumors and corresponding lymph node metastases was 82%. In two cases, the primary tumor was MUC4-positive and the lymph node metastases were negative, while in one patient with a MUC4-negative primary tumor, the lymph node metastasis was positive. The distribution of H-score for expression of MUC4 significantly correlated (r = 0.615; p = 0.009) between primary tumors and paired metastatic lesions. Conclusions: MUC4 was observed in both primary and matched metastatic tumors with a high level of concordance, suggesting that MUC4 expression is retained following PDAC metastasis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Gastroenterology
volume
48
issue
10
pages
1183 - 1187
publisher
Taylor & Francis
external identifiers
  • wos:000324761000011
  • pmid:24047396
  • scopus:84884555918
ISSN
1502-7708
DOI
10.3109/00365521.2013.832368
language
English
LU publication?
yes
id
fa9f5bf6-ff67-42c8-bb9f-2d5ccd815c4f (old id 4065670)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24047396?dopt=Abstract
date added to LUP
2013-10-02 20:57:43
date last changed
2019-02-03 03:24:22
@article{fa9f5bf6-ff67-42c8-bb9f-2d5ccd815c4f,
  abstract     = {Abstract Objective. Mucin 4 (MUC4) is a transmembrane glycoprotein that is expressed in pancreatic ductal adenocarcinoma (PDAC), but not in normal pancreatic tissue. MUC4 has a proposed role in pancreatic tumor progression and metastasis. The purpose of this pilot study was to investigate MUC4 expression during PDAC metastasis by comparing the expression in the primary tumor and paired lymph node metastases from the same patient. Material and methods. Surgical specimens from 17 cases of primary PDAC and paired lymph node metastases were immunohistochemically analyzed for MUC4 expression. The modified histochemical score (H-score) was used for staining assessment. Results. Positive staining for MUC4 was detected in most primary and metastatic PDAC tumors (15/17 vs. 14/17). The concordance for MUC4 expression in primary tumors and corresponding lymph node metastases was 82%. In two cases, the primary tumor was MUC4-positive and the lymph node metastases were negative, while in one patient with a MUC4-negative primary tumor, the lymph node metastasis was positive. The distribution of H-score for expression of MUC4 significantly correlated (r = 0.615; p = 0.009) between primary tumors and paired metastatic lesions. Conclusions: MUC4 was observed in both primary and matched metastatic tumors with a high level of concordance, suggesting that MUC4 expression is retained following PDAC metastasis.},
  author       = {Ansari, Daniel and Urey, Carlos and Gundewar, Chinmay and Bauden, Monika and Andersson, Roland},
  issn         = {1502-7708},
  language     = {eng},
  number       = {10},
  pages        = {1183--1187},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Comparison of MUC4 expression in primary pancreatic cancer and paired lymph node metastases.},
  url          = {http://dx.doi.org/10.3109/00365521.2013.832368},
  volume       = {48},
  year         = {2013},
}