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Sex specific familial risk in lung cancer through changing histologies in Sweden

Hemminki, Kari LU ; Zitricky, Frantisek LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU and Hemminki, Akseli (2025) In International Journal of Cancer 157(5). p.858-866
Abstract

Familial clustering of lung cancer (LC) is related to shared smoking habits but the contribution of other potential factors such as sex or histology is not well known, and these are the subjects of the present study in Sweden. Family relationships (from Multigeneration register) and diagnosed cancers (from Cancer registry) were obtained from the national registers from 1961 to 2021. The overall familial risk for LC was constant from the 1990s but the male familial risk decreased while the female familial risk doubled at the same time when female incidence doubled. The female familial risk for mother-daughter pairs was higher (SIR = 2.2 [2.0–2.3], N = 716) than for father-son pairs (SIR = 1.6 [1.5–1.8], N = 962). The histology-specific... (More)

Familial clustering of lung cancer (LC) is related to shared smoking habits but the contribution of other potential factors such as sex or histology is not well known, and these are the subjects of the present study in Sweden. Family relationships (from Multigeneration register) and diagnosed cancers (from Cancer registry) were obtained from the national registers from 1961 to 2021. The overall familial risk for LC was constant from the 1990s but the male familial risk decreased while the female familial risk doubled at the same time when female incidence doubled. The female familial risk for mother-daughter pairs was higher (SIR = 2.2 [2.0–2.3], N = 716) than for father-son pairs (SIR = 1.6 [1.5–1.8], N = 962). The histology-specific familial risks for adenocarcinoma, squamous cell carcinoma, small cell and large cell carcinoma were highest for concordant histology but also present for discordant histology. The number of family members diagnosed with LC was a strong determinant of familial risk. The novel results showed that familial risk of LC depends on the background incidence of LC and is higher for women compared to men. We demonstrated further an increased familial risk for each of the four histological types of LC which was higher for concordant than discordant histologies but was even detected between discordant histologies suggesting that LC histology is not a genetic trait.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adenocarcinoma, age of onset, incidence trend, proband, sibling risk
in
International Journal of Cancer
volume
157
issue
5
pages
9 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:105001855926
  • pmid:40156379
ISSN
0020-7136
DOI
10.1002/ijc.35431
language
English
LU publication?
yes
id
fb33cc67-495c-4eda-a2be-bb599195818d
date added to LUP
2025-09-02 14:02:07
date last changed
2025-09-03 03:00:03
@article{fb33cc67-495c-4eda-a2be-bb599195818d,
  abstract     = {{<p>Familial clustering of lung cancer (LC) is related to shared smoking habits but the contribution of other potential factors such as sex or histology is not well known, and these are the subjects of the present study in Sweden. Family relationships (from Multigeneration register) and diagnosed cancers (from Cancer registry) were obtained from the national registers from 1961 to 2021. The overall familial risk for LC was constant from the 1990s but the male familial risk decreased while the female familial risk doubled at the same time when female incidence doubled. The female familial risk for mother-daughter pairs was higher (SIR = 2.2 [2.0–2.3], N = 716) than for father-son pairs (SIR = 1.6 [1.5–1.8], N = 962). The histology-specific familial risks for adenocarcinoma, squamous cell carcinoma, small cell and large cell carcinoma were highest for concordant histology but also present for discordant histology. The number of family members diagnosed with LC was a strong determinant of familial risk. The novel results showed that familial risk of LC depends on the background incidence of LC and is higher for women compared to men. We demonstrated further an increased familial risk for each of the four histological types of LC which was higher for concordant than discordant histologies but was even detected between discordant histologies suggesting that LC histology is not a genetic trait.</p>}},
  author       = {{Hemminki, Kari and Zitricky, Frantisek and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Hemminki, Akseli}},
  issn         = {{0020-7136}},
  keywords     = {{adenocarcinoma; age of onset; incidence trend; proband; sibling risk}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{858--866}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Sex specific familial risk in lung cancer through changing histologies in Sweden}},
  url          = {{http://dx.doi.org/10.1002/ijc.35431}},
  doi          = {{10.1002/ijc.35431}},
  volume       = {{157}},
  year         = {{2025}},
}