Towards industrial pentose-fermenting yeast strains
(2007) In Applied Microbiology and Biotechnology 74(5). p.937-953- Abstract
- Production of bioethanol from forest and agricultural products requires a fermenting organism that converts all types of sugars in the raw material to ethanol in high yield and with a high rate. This review summarizes recent research aiming at developing industrial strains of Saccharomyces cerevisiae with the ability to ferment all lignocellulose-derived sugars. The properties required from the industrial yeast strains are discussed in relation to four benchmarks: (1) process water economy, (2) inhibitor tolerance, (3) ethanol yield, and (4) specific ethanol productivity. Of particular importance is the tolerance of the fermenting organism to fermentation inhibitors formed during fractionation/pretreatment and hydrolysis of the raw... (More)
- Production of bioethanol from forest and agricultural products requires a fermenting organism that converts all types of sugars in the raw material to ethanol in high yield and with a high rate. This review summarizes recent research aiming at developing industrial strains of Saccharomyces cerevisiae with the ability to ferment all lignocellulose-derived sugars. The properties required from the industrial yeast strains are discussed in relation to four benchmarks: (1) process water economy, (2) inhibitor tolerance, (3) ethanol yield, and (4) specific ethanol productivity. Of particular importance is the tolerance of the fermenting organism to fermentation inhibitors formed during fractionation/pretreatment and hydrolysis of the raw material, which necessitates the use of robust industrial strain background. While numerous metabolic engineering strategies have been developed in laboratory yeast strains, only a few approaches have been realized in industrial strains. The fermentation performance of the existing industrial pentose-fermenting S. cerevisiae strains in lignocellulose hydrolysate is reviewed. Ethanol yields of more than 0.4 g ethanol/g sugar have been achieved with several xylose-fermenting industrial strains such as TMB 3400, TMB 3006, and 424A(LNF-ST), carrying the heterologous xylose utilization pathway consisting of xylose reductase and xylitol dehydrogenase, which demonstrates the potential of pentose fermentation in improving lignocellulosic ethanol production. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/670283
- author
- Hahn-Hägerdal, Bärbel LU ; Karhumaa, Kaisa LU ; Fonseca, Cesar LU ; Spencer-Martins, Isabel and Gorwa-Grauslund, Marie-Francoise LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Applied Microbiology and Biotechnology
- volume
- 74
- issue
- 5
- pages
- 937 - 953
- publisher
- Springer
- external identifiers
-
- wos:000244996300001
- scopus:33947191174
- ISSN
- 1432-0614
- DOI
- 10.1007/s00253-006-0827-2
- language
- English
- LU publication?
- yes
- id
- fbc12fbe-057b-4d5e-b6ba-ccc730f65b39 (old id 670283)
- date added to LUP
- 2016-04-01 15:27:30
- date last changed
- 2022-04-22 07:47:37
@article{fbc12fbe-057b-4d5e-b6ba-ccc730f65b39,
abstract = {{Production of bioethanol from forest and agricultural products requires a fermenting organism that converts all types of sugars in the raw material to ethanol in high yield and with a high rate. This review summarizes recent research aiming at developing industrial strains of Saccharomyces cerevisiae with the ability to ferment all lignocellulose-derived sugars. The properties required from the industrial yeast strains are discussed in relation to four benchmarks: (1) process water economy, (2) inhibitor tolerance, (3) ethanol yield, and (4) specific ethanol productivity. Of particular importance is the tolerance of the fermenting organism to fermentation inhibitors formed during fractionation/pretreatment and hydrolysis of the raw material, which necessitates the use of robust industrial strain background. While numerous metabolic engineering strategies have been developed in laboratory yeast strains, only a few approaches have been realized in industrial strains. The fermentation performance of the existing industrial pentose-fermenting S. cerevisiae strains in lignocellulose hydrolysate is reviewed. Ethanol yields of more than 0.4 g ethanol/g sugar have been achieved with several xylose-fermenting industrial strains such as TMB 3400, TMB 3006, and 424A(LNF-ST), carrying the heterologous xylose utilization pathway consisting of xylose reductase and xylitol dehydrogenase, which demonstrates the potential of pentose fermentation in improving lignocellulosic ethanol production.}},
author = {{Hahn-Hägerdal, Bärbel and Karhumaa, Kaisa and Fonseca, Cesar and Spencer-Martins, Isabel and Gorwa-Grauslund, Marie-Francoise}},
issn = {{1432-0614}},
language = {{eng}},
number = {{5}},
pages = {{937--953}},
publisher = {{Springer}},
series = {{Applied Microbiology and Biotechnology}},
title = {{Towards industrial pentose-fermenting yeast strains}},
url = {{http://dx.doi.org/10.1007/s00253-006-0827-2}},
doi = {{10.1007/s00253-006-0827-2}},
volume = {{74}},
year = {{2007}},
}