Chromosomal translocations and leukaemia : a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis
(1997) In Leukemia 11(Suppl 3). p.2-271- Abstract
The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed and to be able to heterodimerise with TAL1 to facilitate tumour development.
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https://lup.lub.lu.se/record/fc7a1fc0-1cd9-424a-b377-76cac3ac46cb
- author
- Rabbitts, T H ; Axelson, H LU ; Forster, A ; Grutz, G ; Lavenir, I ; Larson, R ; Osada, H ; Valge-Archer, V ; Wadman, I and Warren, A
- organization
- publishing date
- 1997-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adaptor Proteins, Signal Transducing, Animals, Chromosomes, Human, Pair 11, DNA-Binding Proteins, Erythropoiesis, Hematopoiesis, Humans, LIM Domain Proteins, Leukemia-Lymphoma, Adult T-Cell, Metalloproteins, Mice, Mice, Transgenic, Proto-Oncogene Proteins, Proto-Oncogenes, Transcription, Genetic, Translocation, Genetic
- in
- Leukemia
- volume
- 11
- issue
- Suppl 3
- pages
- 2 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:9209362
- scopus:0030795048
- ISSN
- 0887-6924
- language
- English
- LU publication?
- yes
- id
- fc7a1fc0-1cd9-424a-b377-76cac3ac46cb
- date added to LUP
- 2016-08-09 09:14:01
- date last changed
- 2024-06-14 11:52:17
@article{fc7a1fc0-1cd9-424a-b377-76cac3ac46cb, abstract = {{<p>The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed and to be able to heterodimerise with TAL1 to facilitate tumour development.</p>}}, author = {{Rabbitts, T H and Axelson, H and Forster, A and Grutz, G and Lavenir, I and Larson, R and Osada, H and Valge-Archer, V and Wadman, I and Warren, A}}, issn = {{0887-6924}}, keywords = {{Adaptor Proteins, Signal Transducing; Animals; Chromosomes, Human, Pair 11; DNA-Binding Proteins; Erythropoiesis; Hematopoiesis; Humans; LIM Domain Proteins; Leukemia-Lymphoma, Adult T-Cell; Metalloproteins; Mice; Mice, Transgenic; Proto-Oncogene Proteins; Proto-Oncogenes; Transcription, Genetic; Translocation, Genetic}}, language = {{eng}}, number = {{Suppl 3}}, pages = {{2--271}}, publisher = {{Nature Publishing Group}}, series = {{Leukemia}}, title = {{Chromosomal translocations and leukaemia : a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis}}, volume = {{11}}, year = {{1997}}, }