Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Association of Circulating Long Noncoding 7S RNA with Deep Vein Thrombosis

Wang, Xiao LU ; Memon, Ashfaque A LU orcid ; Hedelius, Anna LU ; Grundberg, Anton LU ; Elf, Johan L LU ; Svensson, Peter J LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2023) In Seminars in Thrombosis and Hemostasis 49(7). p.702-708
Abstract

Mitochondrial dysfunction is a recognized factor in the pathogenesis of deep vein thrombosis (DVT). The role of 7S RNA, a long noncoding RNA that plays an important role in mitochondrial function, in DVT remains unclear. In this study, we aimed to investigate the potential use of 7S RNA as a biomarker in DVT. Plasma samples were obtained from 237 patients (aged 16-95 years) with suspected DVT recruited in a prospective multicenter management study (SCORE) where 53 patients were objectively confirmed with a diagnosis of DVT and the rest were diagnosed as non-DVT. 7S RNA was measured using quantitative real-time polymerase chain reaction in plasma samples. The plasma expression of 7S RNA was significantly lower in DVT compared with... (More)

Mitochondrial dysfunction is a recognized factor in the pathogenesis of deep vein thrombosis (DVT). The role of 7S RNA, a long noncoding RNA that plays an important role in mitochondrial function, in DVT remains unclear. In this study, we aimed to investigate the potential use of 7S RNA as a biomarker in DVT. Plasma samples were obtained from 237 patients (aged 16-95 years) with suspected DVT recruited in a prospective multicenter management study (SCORE) where 53 patients were objectively confirmed with a diagnosis of DVT and the rest were diagnosed as non-DVT. 7S RNA was measured using quantitative real-time polymerase chain reaction in plasma samples. The plasma expression of 7S RNA was significantly lower in DVT compared with non-DVT (0.50 vs. 0.95,
p  = 0.043). With the linear regression analysis, we showed that the association between the plasma expression of 7S RNA and DVT (β = -0.72,
p  = 0.007) was independent of potential confounders. Receiver-operating characteristic curve analysis showed the area under the curve values of 0.60 for 7S RNA. The findings of the present study showed a notable association between 7S RNA and DVT. However, further investigations are needed to fully elucidate the exact role of 7S RNA in the pathophysiology of DVT and its diagnostic value.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Thrombosis and Hemostasis
volume
49
issue
7
pages
702 - 708
publisher
Georg Thieme Verlag
external identifiers
  • scopus:85170856194
  • pmid:37611624
ISSN
1098-9064
DOI
10.1055/s-0043-1772705
language
English
LU publication?
yes
additional info
Thieme. All rights reserved.
id
fc8f2066-6fbb-49b2-afa5-cec3ed896bfe
date added to LUP
2023-09-06 13:00:23
date last changed
2024-04-14 16:53:13
@article{fc8f2066-6fbb-49b2-afa5-cec3ed896bfe,
  abstract     = {{<p>Mitochondrial dysfunction is a recognized factor in the pathogenesis of deep vein thrombosis (DVT). The role of 7S RNA, a long noncoding RNA that plays an important role in mitochondrial function, in DVT remains unclear. In this study, we aimed to investigate the potential use of 7S RNA as a biomarker in DVT. Plasma samples were obtained from 237 patients (aged 16-95 years) with suspected DVT recruited in a prospective multicenter management study (SCORE) where 53 patients were objectively confirmed with a diagnosis of DVT and the rest were diagnosed as non-DVT. 7S RNA was measured using quantitative real-time polymerase chain reaction in plasma samples. The plasma expression of 7S RNA was significantly lower in DVT compared with non-DVT (0.50 vs. 0.95,<br>
 p  = 0.043). With the linear regression analysis, we showed that the association between the plasma expression of 7S RNA and DVT (β = -0.72, <br>
 p  = 0.007) was independent of potential confounders. Receiver-operating characteristic curve analysis showed the area under the curve values of 0.60 for 7S RNA. The findings of the present study showed a notable association between 7S RNA and DVT. However, further investigations are needed to fully elucidate the exact role of 7S RNA in the pathophysiology of DVT and its diagnostic value.<br>
 </p>}},
  author       = {{Wang, Xiao and Memon, Ashfaque A and Hedelius, Anna and Grundberg, Anton and Elf, Johan L and Svensson, Peter J and Sundquist, Jan and Sundquist, Kristina}},
  issn         = {{1098-9064}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{7}},
  pages        = {{702--708}},
  publisher    = {{Georg Thieme Verlag}},
  series       = {{Seminars in Thrombosis and Hemostasis}},
  title        = {{Association of Circulating Long Noncoding 7S RNA with Deep Vein Thrombosis}},
  url          = {{http://dx.doi.org/10.1055/s-0043-1772705}},
  doi          = {{10.1055/s-0043-1772705}},
  volume       = {{49}},
  year         = {{2023}},
}