Association of Circulating Long Noncoding 7S RNA with Deep Vein Thrombosis
(2023) In Seminars in Thrombosis and Hemostasis 49(7). p.702-708- Abstract
Mitochondrial dysfunction is a recognized factor in the pathogenesis of deep vein thrombosis (DVT). The role of 7S RNA, a long noncoding RNA that plays an important role in mitochondrial function, in DVT remains unclear. In this study, we aimed to investigate the potential use of 7S RNA as a biomarker in DVT. Plasma samples were obtained from 237 patients (aged 16-95 years) with suspected DVT recruited in a prospective multicenter management study (SCORE) where 53 patients were objectively confirmed with a diagnosis of DVT and the rest were diagnosed as non-DVT. 7S RNA was measured using quantitative real-time polymerase chain reaction in plasma samples. The plasma expression of 7S RNA was significantly lower in DVT compared with... (More)
Mitochondrial dysfunction is a recognized factor in the pathogenesis of deep vein thrombosis (DVT). The role of 7S RNA, a long noncoding RNA that plays an important role in mitochondrial function, in DVT remains unclear. In this study, we aimed to investigate the potential use of 7S RNA as a biomarker in DVT. Plasma samples were obtained from 237 patients (aged 16-95 years) with suspected DVT recruited in a prospective multicenter management study (SCORE) where 53 patients were objectively confirmed with a diagnosis of DVT and the rest were diagnosed as non-DVT. 7S RNA was measured using quantitative real-time polymerase chain reaction in plasma samples. The plasma expression of 7S RNA was significantly lower in DVT compared with non-DVT (0.50 vs. 0.95,
(Less)
p = 0.043). With the linear regression analysis, we showed that the association between the plasma expression of 7S RNA and DVT (β = -0.72,
p = 0.007) was independent of potential confounders. Receiver-operating characteristic curve analysis showed the area under the curve values of 0.60 for 7S RNA. The findings of the present study showed a notable association between 7S RNA and DVT. However, further investigations are needed to fully elucidate the exact role of 7S RNA in the pathophysiology of DVT and its diagnostic value.
- author
- Wang, Xiao LU ; Memon, Ashfaque A LU ; Hedelius, Anna LU ; Grundberg, Anton LU ; Elf, Johan L LU ; Svensson, Peter J LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2023-08-23
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Seminars in Thrombosis and Hemostasis
- volume
- 49
- issue
- 7
- pages
- 702 - 708
- publisher
- Georg Thieme Verlag
- external identifiers
-
- scopus:85170856194
- pmid:37611624
- ISSN
- 1098-9064
- DOI
- 10.1055/s-0043-1772705
- language
- English
- LU publication?
- yes
- additional info
- Thieme. All rights reserved.
- id
- fc8f2066-6fbb-49b2-afa5-cec3ed896bfe
- date added to LUP
- 2023-09-06 13:00:23
- date last changed
- 2024-04-14 16:53:13
@article{fc8f2066-6fbb-49b2-afa5-cec3ed896bfe, abstract = {{<p>Mitochondrial dysfunction is a recognized factor in the pathogenesis of deep vein thrombosis (DVT). The role of 7S RNA, a long noncoding RNA that plays an important role in mitochondrial function, in DVT remains unclear. In this study, we aimed to investigate the potential use of 7S RNA as a biomarker in DVT. Plasma samples were obtained from 237 patients (aged 16-95 years) with suspected DVT recruited in a prospective multicenter management study (SCORE) where 53 patients were objectively confirmed with a diagnosis of DVT and the rest were diagnosed as non-DVT. 7S RNA was measured using quantitative real-time polymerase chain reaction in plasma samples. The plasma expression of 7S RNA was significantly lower in DVT compared with non-DVT (0.50 vs. 0.95,<br> p = 0.043). With the linear regression analysis, we showed that the association between the plasma expression of 7S RNA and DVT (β = -0.72, <br> p = 0.007) was independent of potential confounders. Receiver-operating characteristic curve analysis showed the area under the curve values of 0.60 for 7S RNA. The findings of the present study showed a notable association between 7S RNA and DVT. However, further investigations are needed to fully elucidate the exact role of 7S RNA in the pathophysiology of DVT and its diagnostic value.<br> </p>}}, author = {{Wang, Xiao and Memon, Ashfaque A and Hedelius, Anna and Grundberg, Anton and Elf, Johan L and Svensson, Peter J and Sundquist, Jan and Sundquist, Kristina}}, issn = {{1098-9064}}, language = {{eng}}, month = {{08}}, number = {{7}}, pages = {{702--708}}, publisher = {{Georg Thieme Verlag}}, series = {{Seminars in Thrombosis and Hemostasis}}, title = {{Association of Circulating Long Noncoding 7S RNA with Deep Vein Thrombosis}}, url = {{http://dx.doi.org/10.1055/s-0043-1772705}}, doi = {{10.1055/s-0043-1772705}}, volume = {{49}}, year = {{2023}}, }