Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.
Ehlén, Åsa LU ; Rossello Castillo, Catalina Ana LU ; von Stedingk, Kristoffer LU ; Eklund, Greta LU ; Nilsson, Elise LU ; Pettersson, Helen LU ; Jirström, Karin LU
and Alvarado-Kristensson, Maria
LU
(2012)
In Journal of Biological Chemistry
287(21).
p.17241-17247
- Abstract
- In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis. Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2519610
- author
- Ehlén, Åsa
LU
; Rossello Castillo, Catalina Ana
LU
; von Stedingk, Kristoffer
LU
; Eklund, Greta
LU
; Nilsson, Elise
LU
; Pettersson, Helen
LU
; Jirström, Karin
LU
and Alvarado-Kristensson, Maria
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biological Chemistry
- volume
- 287
- issue
- 21
- pages
- 17241 - 17247
- publisher
- American Society for Biochemistry and Molecular Biology
- external identifiers
-
- pmid:22493456
- wos:000306373000024
- scopus:84861205944
- pmid:22493456
- ISSN
- 1083-351X
- DOI
- 10.1074/jbc.M112.357038
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology (Malmö) (013031000), Pathology, (Lund) (013030000), Molecular Medicine (013031200), Molecular Tumour Biology (013017540)
- id
- fc9841d0-9d91-4af3-bd7a-5c6e365fd551 (old id 2519610)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22493456?dopt=Abstract
- date added to LUP
- 2016-04-01 09:59:57
- date last changed
- 2024-01-06 05:15:24
@article{fc9841d0-9d91-4af3-bd7a-5c6e365fd551,
abstract = {{In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis. Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.}},
author = {{Ehlén, Åsa and Rossello Castillo, Catalina Ana and von Stedingk, Kristoffer and Eklund, Greta and Nilsson, Elise and Pettersson, Helen and Jirström, Karin and Alvarado-Kristensson, Maria}},
issn = {{1083-351X}},
language = {{eng}},
number = {{21}},
pages = {{17241--17247}},
publisher = {{American Society for Biochemistry and Molecular Biology}},
series = {{Journal of Biological Chemistry}},
title = {{Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.}},
url = {{http://dx.doi.org/10.1074/jbc.M112.357038}},
doi = {{10.1074/jbc.M112.357038}},
volume = {{287}},
year = {{2012}},
}